FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166600411> ?p ?o ?g. }

• W2166600411 endingPage "7825" @default.
• W2166600411 startingPage "7818" @default.
• W2166600411 abstract "Lyme disease is a major human health problem which continues to increase in incidence and geographic distribution. As a vector-borne zoonotic disease, Lyme disease may be amenable to reservoir targeted strategies for control. We have previously reported that a vaccinia virus (VV) based vaccine expressing outer surface protein A (OspA) of Borrelia burgdorferi, the causative agent of Lyme disease, protects inbred strains of laboratory mice against infection by feeding ticks and clears the ticks of infection when administered by gavage. Here we extend these studies to develop an effective bait formulation for delivery of the VV based vaccine and test its characteristics under simulated environmental conditions. We show that this vaccine is efficacious in decreasing acquisition of B. burgdorferi by uninfected larval ticks as well as in decreasing transmission from infected ticks to its natural reservoir, Peromyscus leucopus, when fed to mice in oral baits. Using live, in vivo imaging techniques, we describe the distribution of vaccinia virus infection after ingestion of the baited vaccines and establish the use of in vivo imaging technology for optimization of bait delivery. In summary, a VV based OspA vaccine is stable in an oral bait preparation and provides protection against infection for both the natural reservoir and the tick vector of Lyme disease." @default.
• W2166600411 created "2016-06-24" @default.
• W2166600411 creator A5004340946 @default.
• W2166600411 creator A5046901381 @default.
• W2166600411 creator A5051460873 @default.
• W2166600411 creator A5058915340 @default.
• W2166600411 creator A5087606871 @default.
• W2166600411 creator A5088696094 @default.
• W2166600411 date "2011-10-01" @default.
• W2166600411 modified "2023-10-15" @default.
• W2166600411 title "Development of a baited oral vaccine for use in reservoir-targeted strategies against Lyme disease" @default.
• W2166600411 cites W1250390568 @default.
• W2166600411 cites W1499069904 @default.
• W2166600411 cites W1950464255 @default.
• W2166600411 cites W1954228641 @default.
• W2166600411 cites W1987839705 @default.
• W2166600411 cites W1988874836 @default.
• W2166600411 cites W1995762555 @default.
• W2166600411 cites W2012706326 @default.
• W2166600411 cites W2018800131 @default.
• W2166600411 cites W2020423356 @default.
• W2166600411 cites W2021496389 @default.
• W2166600411 cites W2038564416 @default.
• W2166600411 cites W2043399320 @default.
• W2166600411 cites W2052708490 @default.
• W2166600411 cites W2081004180 @default.
• W2166600411 cites W2085858694 @default.
• W2166600411 cites W2097676739 @default.
• W2166600411 cites W2110695258 @default.
• W2166600411 cites W2121386707 @default.
• W2166600411 cites W2125424682 @default.
• W2166600411 cites W2134488796 @default.
• W2166600411 cites W2153204663 @default.
• W2166600411 cites W2160953240 @default.
• W2166600411 cites W2164871258 @default.
• W2166600411 cites W2257304763 @default.
• W2166600411 cites W2320088211 @default.
• W2166600411 cites W2330607187 @default.
• W2166600411 cites W2402629015 @default.
• W2166600411 doi "https://doi.org/10.1016/j.vaccine.2011.07.100" @default.
• W2166600411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3577423" @default.
• W2166600411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21816190" @default.
• W2166600411 hasPublicationYear "2011" @default.
• W2166600411 type Work @default.
• W2166600411 sameAs 2166600411 @default.
• W2166600411 citedByCount "39" @default.
• W2166600411 countsByYear W21666004112012 @default.
• W2166600411 countsByYear W21666004112013 @default.
• W2166600411 countsByYear W21666004112014 @default.
• W2166600411 countsByYear W21666004112015 @default.
• W2166600411 countsByYear W21666004112016 @default.
• W2166600411 countsByYear W21666004112017 @default.
• W2166600411 countsByYear W21666004112020 @default.
• W2166600411 countsByYear W21666004112021 @default.
• W2166600411 countsByYear W21666004112022 @default.
• W2166600411 countsByYear W21666004112023 @default.
• W2166600411 crossrefType "journal-article" @default.
• W2166600411 hasAuthorship W2166600411A5004340946 @default.
• W2166600411 hasAuthorship W2166600411A5046901381 @default.
• W2166600411 hasAuthorship W2166600411A5051460873 @default.
• W2166600411 hasAuthorship W2166600411A5058915340 @default.
• W2166600411 hasAuthorship W2166600411A5087606871 @default.
• W2166600411 hasAuthorship W2166600411A5088696094 @default.
• W2166600411 hasBestOaLocation W21666004112 @default.
• W2166600411 hasConcept C104317684 @default.
• W2166600411 hasConcept C159047783 @default.
• W2166600411 hasConcept C159654299 @default.
• W2166600411 hasConcept C203014093 @default.
• W2166600411 hasConcept C2522874641 @default.
• W2166600411 hasConcept C2777553296 @default.
• W2166600411 hasConcept C2779159148 @default.
• W2166600411 hasConcept C2779553505 @default.
• W2166600411 hasConcept C2779620486 @default.
• W2166600411 hasConcept C2781356689 @default.
• W2166600411 hasConcept C2781401430 @default.
• W2166600411 hasConcept C40767141 @default.
• W2166600411 hasConcept C55493867 @default.
• W2166600411 hasConcept C86803240 @default.
• W2166600411 hasConcept C90856448 @default.
• W2166600411 hasConcept C92087593 @default.
• W2166600411 hasConceptScore W2166600411C104317684 @default.
• W2166600411 hasConceptScore W2166600411C159047783 @default.
• W2166600411 hasConceptScore W2166600411C159654299 @default.
• W2166600411 hasConceptScore W2166600411C203014093 @default.
• W2166600411 hasConceptScore W2166600411C2522874641 @default.
• W2166600411 hasConceptScore W2166600411C2777553296 @default.
• W2166600411 hasConceptScore W2166600411C2779159148 @default.
• W2166600411 hasConceptScore W2166600411C2779553505 @default.
• W2166600411 hasConceptScore W2166600411C2779620486 @default.
• W2166600411 hasConceptScore W2166600411C2781356689 @default.
• W2166600411 hasConceptScore W2166600411C2781401430 @default.
• W2166600411 hasConceptScore W2166600411C40767141 @default.
• W2166600411 hasConceptScore W2166600411C55493867 @default.
• W2166600411 hasConceptScore W2166600411C86803240 @default.
• W2166600411 hasConceptScore W2166600411C90856448 @default.
• W2166600411 hasConceptScore W2166600411C92087593 @default.
• W2166600411 hasFunder F4320337355 @default.
• W2166600411 hasIssue "44" @default.

• next