Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166643977> ?p ?o ?g. }
- W2166643977 endingPage "67" @default.
- W2166643977 startingPage "55" @default.
- W2166643977 abstract "Radial glia, the neural stem cells of the neocortex, are located in two niches: the ventricular zone and outer subventricular zone. Although outer subventricular zone radial glia may generate the majority of human cortical neurons, their molecular features remain elusive. By analyzing gene expression across single cells, we find that outer radial glia preferentially express genes related to extracellular matrix formation, migration, and stemness, including TNC, PTPRZ1, FAM107A, HOPX, and LIFR. Using dynamic imaging, immunostaining, and clonal analysis, we relate these molecular features to distinctive behaviors of outer radial glia, demonstrate the necessity of STAT3 signaling for their cell cycle progression, and establish their extensive proliferative potential. These results suggest that outer radial glia directly support the subventricular niche through local production of growth factors, potentiation of growth factor signals by extracellular matrix proteins, and activation of self-renewal pathways, thereby enabling the developmental and evolutionary expansion of the human neocortex." @default.
- W2166643977 created "2016-06-24" @default.
- W2166643977 creator A5007271966 @default.
- W2166643977 creator A5015724734 @default.
- W2166643977 creator A5024057870 @default.
- W2166643977 creator A5024869315 @default.
- W2166643977 creator A5028161132 @default.
- W2166643977 creator A5060172577 @default.
- W2166643977 creator A5060253376 @default.
- W2166643977 creator A5068970673 @default.
- W2166643977 creator A5073999422 @default.
- W2166643977 creator A5079091432 @default.
- W2166643977 creator A5082391052 @default.
- W2166643977 creator A5089574332 @default.
- W2166643977 creator A5091291190 @default.
- W2166643977 creator A5091597843 @default.
- W2166643977 date "2015-09-01" @default.
- W2166643977 modified "2023-10-18" @default.
- W2166643977 title "Molecular Identity of Human Outer Radial Glia during Cortical Development" @default.
- W2166643977 cites W1653306654 @default.
- W2166643977 cites W1964964250 @default.
- W2166643977 cites W1967611229 @default.
- W2166643977 cites W1974374273 @default.
- W2166643977 cites W1976325242 @default.
- W2166643977 cites W1976824219 @default.
- W2166643977 cites W1978877503 @default.
- W2166643977 cites W1979371631 @default.
- W2166643977 cites W1985893327 @default.
- W2166643977 cites W1985911270 @default.
- W2166643977 cites W1991572445 @default.
- W2166643977 cites W1995083451 @default.
- W2166643977 cites W1996556203 @default.
- W2166643977 cites W2000345419 @default.
- W2166643977 cites W2002107550 @default.
- W2166643977 cites W2005891911 @default.
- W2166643977 cites W2013723454 @default.
- W2166643977 cites W2021399360 @default.
- W2166643977 cites W2023011577 @default.
- W2166643977 cites W2028589731 @default.
- W2166643977 cites W2030017878 @default.
- W2166643977 cites W2030135612 @default.
- W2166643977 cites W2032321721 @default.
- W2166643977 cites W2032850366 @default.
- W2166643977 cites W2038280158 @default.
- W2166643977 cites W2048883955 @default.
- W2166643977 cites W2051658465 @default.
- W2166643977 cites W2060631152 @default.
- W2166643977 cites W2068384450 @default.
- W2166643977 cites W2070303656 @default.
- W2166643977 cites W2072710787 @default.
- W2166643977 cites W2074812494 @default.
- W2166643977 cites W2083931813 @default.
- W2166643977 cites W2090162743 @default.
- W2166643977 cites W2092682926 @default.
- W2166643977 cites W2093885717 @default.
- W2166643977 cites W2094911240 @default.
- W2166643977 cites W2096173332 @default.
- W2166643977 cites W2096589182 @default.
- W2166643977 cites W2106176161 @default.
- W2166643977 cites W2106520658 @default.
- W2166643977 cites W2113249378 @default.
- W2166643977 cites W2119898992 @default.
- W2166643977 cites W2124940469 @default.
- W2166643977 cites W2131282078 @default.
- W2166643977 cites W2140846760 @default.
- W2166643977 cites W2141932458 @default.
- W2166643977 cites W2147826431 @default.
- W2166643977 cites W2158154597 @default.
- W2166643977 cites W2163302580 @default.
- W2166643977 cites W2169390063 @default.
- W2166643977 cites W2169786878 @default.
- W2166643977 doi "https://doi.org/10.1016/j.cell.2015.09.004" @default.
- W2166643977 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4583716" @default.
- W2166643977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26406371" @default.
- W2166643977 hasPublicationYear "2015" @default.
- W2166643977 type Work @default.
- W2166643977 sameAs 2166643977 @default.
- W2166643977 citedByCount "643" @default.
- W2166643977 countsByYear W21666439772014 @default.
- W2166643977 countsByYear W21666439772015 @default.
- W2166643977 countsByYear W21666439772016 @default.
- W2166643977 countsByYear W21666439772017 @default.
- W2166643977 countsByYear W21666439772018 @default.
- W2166643977 countsByYear W21666439772019 @default.
- W2166643977 countsByYear W21666439772020 @default.
- W2166643977 countsByYear W21666439772021 @default.
- W2166643977 countsByYear W21666439772022 @default.
- W2166643977 countsByYear W21666439772023 @default.
- W2166643977 crossrefType "journal-article" @default.
- W2166643977 hasAuthorship W2166643977A5007271966 @default.
- W2166643977 hasAuthorship W2166643977A5015724734 @default.
- W2166643977 hasAuthorship W2166643977A5024057870 @default.
- W2166643977 hasAuthorship W2166643977A5024869315 @default.
- W2166643977 hasAuthorship W2166643977A5028161132 @default.
- W2166643977 hasAuthorship W2166643977A5060172577 @default.
- W2166643977 hasAuthorship W2166643977A5060253376 @default.
- W2166643977 hasAuthorship W2166643977A5068970673 @default.
- W2166643977 hasAuthorship W2166643977A5073999422 @default.