FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166687041> ?p ?o ?g. }

• W2166687041 abstract "Oral and pharyngeal cancer (OPC) of multifactorial aetiology is a major health problem globally. Ranking first in all cancers, OPC poses a significant impact on the Sri Lankan male population. As Human Papillomavirus (HPV) high risk (HR) types are found to be significant risk factors for OPC globally, the current study was undertaken to examine the association between HR-HPV16 and 18 types with OPC in Sri Lanka. Serum samples of 78 OPC patients and 51 non-cancer controls were assayed for the presence of anti-HPV16 and anti-HPV18 IgG antibodies using in-house established Enzyme Linked Immunosorbent Assays (ELISAs). The association between OPC and its risk factors i.e. HPV, smoking, alcohol, betel quid, poor dentition, was established using Chi-square test. Logistic regression was used to calculate odds ratios (OR), adjusted for the influence of other risk factors. This prototype study in Sri Lanka showed a significant risk of 15 fold in developing OPC due to HPV16/18 seropositivity after removing variability due to other factors. Oncogenic HPV18 showed a higher rate of seropositivity being detected in 32% of OPC patients, and also in 2% of non-cancer control subjects. HR-HPV16 was detected in 23% of OPC patients and in 5.88% of controls. Moreover, seven OPC patients were detected with both anti-HPV16 and anti-HPV18 antibodies. According to the logistic regression models HPV18 seropositivity was associated with a 28 fold risk in developing OPC while that of HPV16 was associated with a 6 fold increase in risk for the development of OPC. A 5 fold risk of developing OPC was also pronounced among smokers while alcohol, betel and poor dentition was not significantly associated with OPC. Statistically significant differences with regard to age, gender, smoking, alcohol, betel use, poor dentition and site specificity of the tumour was not observed between HPV seropositive and seronegative OPC patients. Both in-house developed ELISAs detected significant proportions of HPV seropositives within the OPC study population suggestive of HPV as a strong risk factor for oral and pharyngeal carcinogenesis in Sri Lanka." @default.
• W2166687041 created "2016-06-24" @default.
• W2166687041 creator A5006423856 @default.
• W2166687041 creator A5052357336 @default.
• W2166687041 creator A5073998104 @default.
• W2166687041 creator A5077196280 @default.
• W2166687041 date "2015-04-16" @default.
• W2166687041 modified "2023-09-26" @default.
• W2166687041 title "A shifting paradigm in the aetiology of oral and pharyngeal cancer in Sri Lanka: a case-control study providing serologic evidence for the role of oncogenic HPV types 16 and 18" @default.
• W2166687041 cites W1522875484 @default.
• W2166687041 cites W1964406043 @default.
• W2166687041 cites W1984116545 @default.
• W2166687041 cites W1984452143 @default.
• W2166687041 cites W1986335721 @default.
• W2166687041 cites W1988406403 @default.
• W2166687041 cites W1992851901 @default.
• W2166687041 cites W2010866631 @default.
• W2166687041 cites W2013945431 @default.
• W2166687041 cites W2014201296 @default.
• W2166687041 cites W2019232882 @default.
• W2166687041 cites W2028391420 @default.
• W2166687041 cites W2034921429 @default.
• W2166687041 cites W2044757593 @default.
• W2166687041 cites W2048180903 @default.
• W2166687041 cites W2052093507 @default.
• W2166687041 cites W2076029531 @default.
• W2166687041 cites W2079910321 @default.
• W2166687041 cites W2094500109 @default.
• W2166687041 cites W2095253802 @default.
• W2166687041 cites W2100978320 @default.
• W2166687041 cites W2103276255 @default.
• W2166687041 cites W2105549094 @default.
• W2166687041 cites W2112028495 @default.
• W2166687041 cites W2114813165 @default.
• W2166687041 cites W2115945191 @default.
• W2166687041 cites W2118441422 @default.
• W2166687041 cites W2124891284 @default.
• W2166687041 cites W2129669354 @default.
• W2166687041 cites W2134442572 @default.
• W2166687041 cites W2141274038 @default.
• W2166687041 cites W2143019738 @default.
• W2166687041 cites W2148419968 @default.
• W2166687041 cites W2148818765 @default.
• W2166687041 cites W2161299995 @default.
• W2166687041 cites W2165249447 @default.
• W2166687041 cites W2165279145 @default.
• W2166687041 cites W2168981987 @default.
• W2166687041 cites W2171231966 @default.
• W2166687041 cites W2188349143 @default.
• W2166687041 cites W2342166036 @default.
• W2166687041 cites W4240880375 @default.
• W2166687041 cites W4291982476 @default.
• W2166687041 doi "https://doi.org/10.1186/s13027-015-0007-z" @default.
• W2166687041 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4407420" @default.
• W2166687041 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25908938" @default.
• W2166687041 hasPublicationYear "2015" @default.
• W2166687041 type Work @default.
• W2166687041 sameAs 2166687041 @default.
• W2166687041 citedByCount "8" @default.
• W2166687041 countsByYear W21666870412016 @default.
• W2166687041 countsByYear W21666870412019 @default.
• W2166687041 countsByYear W21666870412021 @default.
• W2166687041 countsByYear W21666870412023 @default.
• W2166687041 crossrefType "journal-article" @default.
• W2166687041 hasAuthorship W2166687041A5006423856 @default.
• W2166687041 hasAuthorship W2166687041A5052357336 @default.
• W2166687041 hasAuthorship W2166687041A5073998104 @default.
• W2166687041 hasAuthorship W2166687041A5077196280 @default.
• W2166687041 hasBestOaLocation W21666870411 @default.
• W2166687041 hasConcept C121608353 @default.
• W2166687041 hasConcept C126322002 @default.
• W2166687041 hasConcept C137627325 @default.
• W2166687041 hasConcept C143998085 @default.
• W2166687041 hasConcept C146304588 @default.
• W2166687041 hasConcept C151956035 @default.
• W2166687041 hasConcept C156957248 @default.
• W2166687041 hasConcept C159654299 @default.
• W2166687041 hasConcept C203014093 @default.
• W2166687041 hasConcept C2549261 @default.
• W2166687041 hasConcept C3017649214 @default.
• W2166687041 hasConcept C3019281177 @default.
• W2166687041 hasConcept C45189115 @default.
• W2166687041 hasConcept C71924100 @default.
• W2166687041 hasConcept C95457728 @default.
• W2166687041 hasConceptScore W2166687041C121608353 @default.
• W2166687041 hasConceptScore W2166687041C126322002 @default.
• W2166687041 hasConceptScore W2166687041C137627325 @default.
• W2166687041 hasConceptScore W2166687041C143998085 @default.
• W2166687041 hasConceptScore W2166687041C146304588 @default.
• W2166687041 hasConceptScore W2166687041C151956035 @default.
• W2166687041 hasConceptScore W2166687041C156957248 @default.
• W2166687041 hasConceptScore W2166687041C159654299 @default.
• W2166687041 hasConceptScore W2166687041C203014093 @default.
• W2166687041 hasConceptScore W2166687041C2549261 @default.
• W2166687041 hasConceptScore W2166687041C3017649214 @default.
• W2166687041 hasConceptScore W2166687041C3019281177 @default.
• W2166687041 hasConceptScore W2166687041C45189115 @default.
• W2166687041 hasConceptScore W2166687041C71924100 @default.
• W2166687041 hasConceptScore W2166687041C95457728 @default.
• W2166687041 hasIssue "1" @default.

• next