Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166723971> ?p ?o ?g. }
- W2166723971 endingPage "2442" @default.
- W2166723971 startingPage "2432" @default.
- W2166723971 abstract "Heterochromatin protein 1 (HP1) family members (alpha, beta, and gamma) bind histone H3 methylated at Lys-9, leading to gene silencing and heterochromatin formation. Several previous reports have suggested that HP1s are post-translationally modified, yet sites of modification have not yet been exhaustively determined. Here we perform the first comprehensive proteomic analysis of all HP1 isoforms using tandem mass spectrometry. Our data reveal that all HP1 isoforms are highly modified in a manner analogous to histones including phosphorylation, acetylation, methylation, and formylation, including several sites having multiple different types of modifications. Additionally, many of these modifications are found in both the chromo- and chromoshadow domains, suggesting that they may have an important role in modulating HP1 interactions or functions. These studies are the first to systematically map the abundant sites of covalent modifications on HP1 isoforms and provide the foundation for future investigations to test whether these modifications are essential in heterochromatin maintenance or other nuclear processes." @default.
- W2166723971 created "2016-06-24" @default.
- W2166723971 creator A5007485715 @default.
- W2166723971 creator A5009228621 @default.
- W2166723971 creator A5032318341 @default.
- W2166723971 creator A5033126095 @default.
- W2166723971 creator A5045812906 @default.
- W2166723971 creator A5074470144 @default.
- W2166723971 date "2009-11-01" @default.
- W2166723971 modified "2023-10-05" @default.
- W2166723971 title "Heterochromatin Protein 1 Is Extensively Decorated with Histone Code-like Post-translational Modifications" @default.
- W2166723971 cites W1505028290 @default.
- W2166723971 cites W1534399129 @default.
- W2166723971 cites W1963696308 @default.
- W2166723971 cites W1970543749 @default.
- W2166723971 cites W1981452104 @default.
- W2166723971 cites W1982453928 @default.
- W2166723971 cites W1993765638 @default.
- W2166723971 cites W1996810566 @default.
- W2166723971 cites W2002698073 @default.
- W2166723971 cites W2003236418 @default.
- W2166723971 cites W2010487837 @default.
- W2166723971 cites W2019002796 @default.
- W2166723971 cites W2019793582 @default.
- W2166723971 cites W2026501344 @default.
- W2166723971 cites W2033997324 @default.
- W2166723971 cites W2040285686 @default.
- W2166723971 cites W2040632154 @default.
- W2166723971 cites W2041787701 @default.
- W2166723971 cites W2044731117 @default.
- W2166723971 cites W2045006215 @default.
- W2166723971 cites W2049118388 @default.
- W2166723971 cites W2061946349 @default.
- W2166723971 cites W2067724937 @default.
- W2166723971 cites W2068946710 @default.
- W2166723971 cites W2073127919 @default.
- W2166723971 cites W2078594804 @default.
- W2166723971 cites W2080791829 @default.
- W2166723971 cites W2084690558 @default.
- W2166723971 cites W2090571513 @default.
- W2166723971 cites W2099018124 @default.
- W2166723971 cites W2104726963 @default.
- W2166723971 cites W2107938115 @default.
- W2166723971 cites W2110399580 @default.
- W2166723971 cites W2110576677 @default.
- W2166723971 cites W2110796359 @default.
- W2166723971 cites W2112078820 @default.
- W2166723971 cites W2115008617 @default.
- W2166723971 cites W2126094650 @default.
- W2166723971 cites W2137107848 @default.
- W2166723971 cites W2143264878 @default.
- W2166723971 cites W2151026121 @default.
- W2166723971 cites W2155182074 @default.
- W2166723971 cites W2162813418 @default.
- W2166723971 cites W268483222 @default.
- W2166723971 doi "https://doi.org/10.1074/mcp.m900160-mcp200" @default.
- W2166723971 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2773712" @default.
- W2166723971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19567367" @default.
- W2166723971 hasPublicationYear "2009" @default.
- W2166723971 type Work @default.
- W2166723971 sameAs 2166723971 @default.
- W2166723971 citedByCount "90" @default.
- W2166723971 countsByYear W21667239712012 @default.
- W2166723971 countsByYear W21667239712013 @default.
- W2166723971 countsByYear W21667239712014 @default.
- W2166723971 countsByYear W21667239712015 @default.
- W2166723971 countsByYear W21667239712016 @default.
- W2166723971 countsByYear W21667239712017 @default.
- W2166723971 countsByYear W21667239712018 @default.
- W2166723971 countsByYear W21667239712019 @default.
- W2166723971 countsByYear W21667239712020 @default.
- W2166723971 countsByYear W21667239712021 @default.
- W2166723971 countsByYear W21667239712022 @default.
- W2166723971 countsByYear W21667239712023 @default.
- W2166723971 crossrefType "journal-article" @default.
- W2166723971 hasAuthorship W2166723971A5007485715 @default.
- W2166723971 hasAuthorship W2166723971A5009228621 @default.
- W2166723971 hasAuthorship W2166723971A5032318341 @default.
- W2166723971 hasAuthorship W2166723971A5033126095 @default.
- W2166723971 hasAuthorship W2166723971A5045812906 @default.
- W2166723971 hasAuthorship W2166723971A5074470144 @default.
- W2166723971 hasBestOaLocation W21667239711 @default.
- W2166723971 hasConcept C103435993 @default.
- W2166723971 hasConcept C104317684 @default.
- W2166723971 hasConcept C119157956 @default.
- W2166723971 hasConcept C121912465 @default.
- W2166723971 hasConcept C150194340 @default.
- W2166723971 hasConcept C185592680 @default.
- W2166723971 hasConcept C190727270 @default.
- W2166723971 hasConcept C50171091 @default.
- W2166723971 hasConcept C53345823 @default.
- W2166723971 hasConcept C54355233 @default.
- W2166723971 hasConcept C64927066 @default.
- W2166723971 hasConcept C70721500 @default.
- W2166723971 hasConcept C83640560 @default.
- W2166723971 hasConcept C86803240 @default.
- W2166723971 hasConcept C92149661 @default.
- W2166723971 hasConcept C95444343 @default.