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• W2166760958 abstract "To the Editor: Sahgal et al ( 1 Sahgal A. Aoyama H. Kocher M. et al. Phase 3 trials of stereotactic radiosurgery with or without whole-brain radiation therapy for 1 to 4 brain metastases: Individual patient data meta-analysis. Int J Radiat Oncol Biol Phys. 2015; 91: 710-717 Abstract Full Text Full Text PDF PubMed Scopus (298) Google Scholar ) have challenged the role of adding whole-brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) for patients with limited brain metastases in their recent meta-analysis. They concluded that addition of WBRT to SRS is detrimental with respect to survival for patients aged <50 years. Their meta-analysis and conclusions are based on 3 randomized trials including only 364 patients with different tumors and with different prognosis and survivals. They think that “the sun is setting on WBRT, and SRS alone is rising to be the standard of care”; however, we think that there is a big methodological mistake in their meta-analysis ( 2 Sahgal A. Larson D. Knisely J. Stereotactic radiosurgery alone for brain metastases. Lancet Oncol. 2015; 16: 249-250 Abstract Full Text Full Text PDF PubMed Scopus (41) Google Scholar ). Phase 3 Trials of Stereotactic Radiosurgery With or Without Whole-Brain Radiation Therapy for 1 to 4 Brain Metastases: Individual Patient Data Meta-AnalysisInternational Journal of Radiation Oncology, Biology, PhysicsVol. 91Issue 4PreviewTo perform an individual patient data (IPD) meta-analysis of randomized controlled trials evaluating stereotactic radiosurgery (SRS) with or without whole-brain radiation therapy (WBRT) for patients presenting with 1 to 4 brain metastases. Full-Text PDF Open AccessIn Reply to Gemici and Yaprak and Lowrey and MarcusInternational Journal of Radiation Oncology, Biology, PhysicsVol. 92Issue 4PreviewTo the Editor: Drs Gemici and Yaprak (1) and Drs Lowrey and Marcus (2) reiterate the known benefits of whole-brain radiation therapy (WBRT) and limitations of our study, including histology, as did we in our report (3). However, both fail to acknowledge its now widely recognized neurocognitive toxicity (4-7). Even if overall survival for younger patients were not more favorable in the SRS-alone group, contrary to our findings, would they deliver WBRT to those patients, knowing they would cause neurocognitive decline? We would not. Full-Text PDF" @default.
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• W2166760958 date "2015-07-01" @default.
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• W2166760958 title "In Regard to Sahgal et al" @default.
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• W2166760958 doi "https://doi.org/10.1016/j.ijrobp.2015.04.012" @default.
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