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• W2166773361 abstract "Objective To investigate the efficacy and safety of telmisartan 80 mg/amlodipine 5 mg (T80/A5) single-pill combination versus A5 in patients with essential hypertension not adequately controlled on A5 monotherapy. Methods Asian patients ≥18 years old, with inadequately controlled blood pressure (BP) at enrolment, who failed to achieve a seated diastolic BP (DBP) goal (≥90 mmHg) following 6-weeks’ open-label A5 treatment, were randomly allocated 1 : 1 to 8 weeks’ double-blind treatment with T80/A5 single-pill combination or A5. Results A total of 324 patients entered the double-blind treatment phase. The adjusted mean ± SE reduction in seated trough DBP from baseline to week 8 was significantly greater with T80/A5 (12.4 ± 1.0 mmHg) than A5 (10.2 ± 0.9 mmHg [primary endpoint, n = 314]). Results were similar in the subset of 262 Chinese patients. Treatment-related adverse events were 1.9% with T80/A5 and 2.4% with A5. Conclusions In Asian patients with hypertension, T80/A5 single-pill combination provided improved BP reduction after 8 weeks’ treatment compared with A5 monotherapy. Both treatments were well tolerated." @default.
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• W2166773361 date "2014-01-03" @default.
• W2166773361 modified "2023-09-25" @default.
• W2166773361 title "A randomized, double-blind study to evaluate the efficacy and safety of a single-pill combination of telmisartan 80 mg/amlodipine 5 mg versus amlodipine 5 mg in hypertensive Asian patients" @default.
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• W2166773361 doi "https://doi.org/10.1177/0300060513503756" @default.
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