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- W2166780974 abstract "Classical descriptions of the three-dimensional shapes of proteins usually invoke three main structures: α-helix, β-sheet, and β-turn. More recently, the polyproline II (PPII) structure has been implicated in diverse biological activities including signal transduction, transcription, cell motility, and immune response. Concurrently, evidence is accumulating that PPII structure has a significant role in the unfolded states of proteins. In this article, we connect the structural properties of PPII helices to their roles in protein recognition and protein unfolded states. The properties unique to the PPII conformation are linked to the exploitation of this structure for the molecular recognition of proteins, using peptide ligands of the Src homology 3 (SH3) domain as an example. The evidence supporting a role for PPII conformation in protein-unfolded states is also presented in the context of the forces that may stabilize the PPII conformation in unfolded polypeptides. © Wiley Periodicals Inc. Biopolymers (Pept Sci), 2005" @default.
- W2166780974 created "2016-06-24" @default.
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- W2166780974 date "2005-01-01" @default.
- W2166780974 modified "2023-09-25" @default.
- W2166780974 title "The structure of ?unstructured? regions in peptides and proteins: Role of the polyproline II helix in protein folding and recognition" @default.
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- W2166780974 doi "https://doi.org/10.1002/bip.20227" @default.
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