FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166783943> ?p ?o ?g. }

• W2166783943 endingPage "10" @default.
• W2166783943 startingPage "4" @default.
• W2166783943 abstract "Ciguatoxins are the major toxins responsible for ciguatera fish poisoning, a disease dominated by muco-cutaneous sensory disorders including paresthesiae, cold dysesthesia and pruritus. While the ciguatoxins are well known to target voltage-gated sodium channels (VGSCs), the ensuing molecular mechanisms underlying these sensory disorders remain poorly understood. In this study, we propose a primary sensory neuron-keratinocyte co-culture as an appropriate model to study the neuro-cutaneous effects of ciguatoxins. Using this model, we show for the first time that nanomolar concentrations of Pacific ciguatoxin-2 (P-CTX-2) induced a VGSC-dependent release of substance P (SP) and calcitonin gene-related peptide (CGRP). As these neuropeptides are known mediators of pain and itch sensations, the ciguatoxin-induced sensory disturbances in ciguatera fish poisoning may involve the release of these neuropeptides. We further determined time- and P-CTX-2 concentration-dependence of the release of SP and CGRP from the co-culture model. Moreover, we highlighted the influence of extracellular calcium on the release of neuropeptides elicited by P-CTX-2. These findings underline the usefulness of this novel in vitro model for studying the cellular and molecular mechanisms of the neuro-cutaneous effects of ciguatoxins, which may assist with identifying potential therapeutics for ciguatera fish poisoning." @default.
• W2166783943 created "2016-06-24" @default.
• W2166783943 creator A5005160521 @default.
• W2166783943 creator A5005402821 @default.
• W2166783943 creator A5006736676 @default.
• W2166783943 creator A5025539645 @default.
• W2166783943 creator A5054144098 @default.
• W2166783943 creator A5064888565 @default.
• W2166783943 creator A5065521555 @default.
• W2166783943 creator A5065641480 @default.
• W2166783943 creator A5066863400 @default.
• W2166783943 creator A5087905603 @default.
• W2166783943 date "2016-06-01" @default.
• W2166783943 modified "2023-10-14" @default.
• W2166783943 title "Release of neuropeptides from a neuro-cutaneous co-culture model: A novel in vitro model for studying sensory effects of ciguatoxins" @default.
• W2166783943 cites W1492050775 @default.
• W2166783943 cites W1520866342 @default.
• W2166783943 cites W1523180499 @default.
• W2166783943 cites W1534292108 @default.
• W2166783943 cites W1714184251 @default.
• W2166783943 cites W1912145110 @default.
• W2166783943 cites W1926176136 @default.
• W2166783943 cites W1958942090 @default.
• W2166783943 cites W1976584936 @default.
• W2166783943 cites W1982884977 @default.
• W2166783943 cites W1988242734 @default.
• W2166783943 cites W1989549756 @default.
• W2166783943 cites W1992319505 @default.
• W2166783943 cites W2007903071 @default.
• W2166783943 cites W2021640479 @default.
• W2166783943 cites W2022336570 @default.
• W2166783943 cites W2025064558 @default.
• W2166783943 cites W2026007886 @default.
• W2166783943 cites W2049859629 @default.
• W2166783943 cites W2053185221 @default.
• W2166783943 cites W2054080192 @default.
• W2166783943 cites W2054154753 @default.
• W2166783943 cites W2054969360 @default.
• W2166783943 cites W2060749212 @default.
• W2166783943 cites W2073806994 @default.
• W2166783943 cites W2074418365 @default.
• W2166783943 cites W2081163703 @default.
• W2166783943 cites W2082584417 @default.
• W2166783943 cites W2084961143 @default.
• W2166783943 cites W2086073577 @default.
• W2166783943 cites W2114000842 @default.
• W2166783943 cites W2115809711 @default.
• W2166783943 cites W2122003688 @default.
• W2166783943 cites W2134321467 @default.
• W2166783943 cites W2142584401 @default.
• W2166783943 cites W2144946015 @default.
• W2166783943 cites W2149284140 @default.
• W2166783943 cites W2151917482 @default.
• W2166783943 cites W2340956211 @default.
• W2166783943 cites W4211156397 @default.
• W2166783943 doi "https://doi.org/10.1016/j.toxicon.2015.11.004" @default.
• W2166783943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26562445" @default.
• W2166783943 hasPublicationYear "2016" @default.
• W2166783943 type Work @default.
• W2166783943 sameAs 2166783943 @default.
• W2166783943 citedByCount "17" @default.
• W2166783943 countsByYear W21667839432016 @default.
• W2166783943 countsByYear W21667839432017 @default.
• W2166783943 countsByYear W21667839432018 @default.
• W2166783943 countsByYear W21667839432019 @default.
• W2166783943 countsByYear W21667839432020 @default.
• W2166783943 countsByYear W21667839432021 @default.
• W2166783943 countsByYear W21667839432023 @default.
• W2166783943 crossrefType "journal-article" @default.
• W2166783943 hasAuthorship W2166783943A5005160521 @default.
• W2166783943 hasAuthorship W2166783943A5005402821 @default.
• W2166783943 hasAuthorship W2166783943A5006736676 @default.
• W2166783943 hasAuthorship W2166783943A5025539645 @default.
• W2166783943 hasAuthorship W2166783943A5054144098 @default.
• W2166783943 hasAuthorship W2166783943A5064888565 @default.
• W2166783943 hasAuthorship W2166783943A5065521555 @default.
• W2166783943 hasAuthorship W2166783943A5065641480 @default.
• W2166783943 hasAuthorship W2166783943A5066863400 @default.
• W2166783943 hasAuthorship W2166783943A5087905603 @default.
• W2166783943 hasConcept C118303440 @default.
• W2166783943 hasConcept C145316831 @default.
• W2166783943 hasConcept C163170386 @default.
• W2166783943 hasConcept C169760540 @default.
• W2166783943 hasConcept C170493617 @default.
• W2166783943 hasConcept C185592680 @default.
• W2166783943 hasConcept C2776533618 @default.
• W2166783943 hasConcept C2779937837 @default.
• W2166783943 hasConcept C2780051329 @default.
• W2166783943 hasConcept C2909208804 @default.
• W2166783943 hasConcept C505870484 @default.
• W2166783943 hasConcept C55493867 @default.
• W2166783943 hasConcept C86803240 @default.
• W2166783943 hasConcept C98274493 @default.
• W2166783943 hasConceptScore W2166783943C118303440 @default.
• W2166783943 hasConceptScore W2166783943C145316831 @default.
• W2166783943 hasConceptScore W2166783943C163170386 @default.
• W2166783943 hasConceptScore W2166783943C169760540 @default.
• W2166783943 hasConceptScore W2166783943C170493617 @default.

• next