Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166792528> ?p ?o ?g. }
- W2166792528 endingPage "L787" @default.
- W2166792528 startingPage "L778" @default.
- W2166792528 abstract "Cigarette smoking is the strongest risk factor for emphysema. However, sensitivity to cigarette smoke-induced emphysema is highly variable, and numerous genetic and environmental factors are thought to mitigate lung response to injury. We report that the quantity of functional elastin in the lung is an important modifier of both lung development and response to injury. In mice with low levels of elastin, lung development is adversely affected, and mice manifest with congenital emphysema. Animals with intermediate elastin levels exhibit normal alveolar structure but develop worse emphysema than normal mice following cigarette smoke exposure. Mechanical testing demonstrates that lungs with low levels of elastin experience greater tissue strains for any given tissue stress compared with wild-type lungs, implying that force-mediated propagation of lung injury through alveolar wall failure may worsen the emphysema after an initial enzymatic insult. Our findings suggest that quantitative deficiencies in elastin predispose to smoke-induce emphysema in animal models and suggest that humans with altered levels of functional elastin could have relatively normal lung function while being more susceptible to smoke-induced lung injury." @default.
- W2166792528 created "2016-06-24" @default.
- W2166792528 creator A5023087890 @default.
- W2166792528 creator A5028319596 @default.
- W2166792528 creator A5033707084 @default.
- W2166792528 creator A5055806663 @default.
- W2166792528 creator A5068418680 @default.
- W2166792528 date "2007-03-01" @default.
- W2166792528 modified "2023-09-28" @default.
- W2166792528 title "Elastin protein levels are a vital modifier affecting normal lung development and susceptibility to emphysema" @default.
- W2166792528 cites W1564135085 @default.
- W2166792528 cites W1604907834 @default.
- W2166792528 cites W1664754128 @default.
- W2166792528 cites W176473010 @default.
- W2166792528 cites W1780521007 @default.
- W2166792528 cites W1802967718 @default.
- W2166792528 cites W1966784184 @default.
- W2166792528 cites W1983344336 @default.
- W2166792528 cites W1985607536 @default.
- W2166792528 cites W1993744211 @default.
- W2166792528 cites W1998682046 @default.
- W2166792528 cites W2004719527 @default.
- W2166792528 cites W2011022215 @default.
- W2166792528 cites W2037394705 @default.
- W2166792528 cites W2041764051 @default.
- W2166792528 cites W2046301895 @default.
- W2166792528 cites W2046627607 @default.
- W2166792528 cites W2054248890 @default.
- W2166792528 cites W2066193611 @default.
- W2166792528 cites W2077317762 @default.
- W2166792528 cites W2083398588 @default.
- W2166792528 cites W2084311974 @default.
- W2166792528 cites W2090262871 @default.
- W2166792528 cites W2097582641 @default.
- W2166792528 cites W2099969611 @default.
- W2166792528 cites W2100192859 @default.
- W2166792528 cites W2104382047 @default.
- W2166792528 cites W2105161580 @default.
- W2166792528 cites W2105216609 @default.
- W2166792528 cites W2108934505 @default.
- W2166792528 cites W2112015469 @default.
- W2166792528 cites W2115714868 @default.
- W2166792528 cites W2118522871 @default.
- W2166792528 cites W2118723878 @default.
- W2166792528 cites W2121774438 @default.
- W2166792528 cites W2121954647 @default.
- W2166792528 cites W2122588714 @default.
- W2166792528 cites W2139930644 @default.
- W2166792528 cites W2143286808 @default.
- W2166792528 cites W2144473231 @default.
- W2166792528 cites W2149926252 @default.
- W2166792528 cites W2153231621 @default.
- W2166792528 cites W2154556245 @default.
- W2166792528 cites W2156634951 @default.
- W2166792528 cites W2167080502 @default.
- W2166792528 cites W2171046456 @default.
- W2166792528 cites W2171591131 @default.
- W2166792528 cites W2238027795 @default.
- W2166792528 cites W2268083416 @default.
- W2166792528 cites W3027631944 @default.
- W2166792528 cites W4210961984 @default.
- W2166792528 doi "https://doi.org/10.1152/ajplung.00352.2006" @default.
- W2166792528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17142349" @default.
- W2166792528 hasPublicationYear "2007" @default.
- W2166792528 type Work @default.
- W2166792528 sameAs 2166792528 @default.
- W2166792528 citedByCount "83" @default.
- W2166792528 countsByYear W21667925282012 @default.
- W2166792528 countsByYear W21667925282013 @default.
- W2166792528 countsByYear W21667925282014 @default.
- W2166792528 countsByYear W21667925282015 @default.
- W2166792528 countsByYear W21667925282016 @default.
- W2166792528 countsByYear W21667925282017 @default.
- W2166792528 countsByYear W21667925282018 @default.
- W2166792528 countsByYear W21667925282019 @default.
- W2166792528 countsByYear W21667925282020 @default.
- W2166792528 countsByYear W21667925282021 @default.
- W2166792528 countsByYear W21667925282022 @default.
- W2166792528 countsByYear W21667925282023 @default.
- W2166792528 crossrefType "journal-article" @default.
- W2166792528 hasAuthorship W2166792528A5023087890 @default.
- W2166792528 hasAuthorship W2166792528A5028319596 @default.
- W2166792528 hasAuthorship W2166792528A5033707084 @default.
- W2166792528 hasAuthorship W2166792528A5055806663 @default.
- W2166792528 hasAuthorship W2166792528A5068418680 @default.
- W2166792528 hasConcept C126322002 @default.
- W2166792528 hasConcept C142724271 @default.
- W2166792528 hasConcept C2777714996 @default.
- W2166792528 hasConcept C2779869378 @default.
- W2166792528 hasConcept C2993351451 @default.
- W2166792528 hasConcept C534529494 @default.
- W2166792528 hasConcept C71924100 @default.
- W2166792528 hasConcept C99454951 @default.
- W2166792528 hasConceptScore W2166792528C126322002 @default.
- W2166792528 hasConceptScore W2166792528C142724271 @default.
- W2166792528 hasConceptScore W2166792528C2777714996 @default.
- W2166792528 hasConceptScore W2166792528C2779869378 @default.
- W2166792528 hasConceptScore W2166792528C2993351451 @default.