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• W2166851592 abstract "Through cognate interaction between antigen-specific B-cell and CD4(+) alphabeta T cells, the CD4(+) alphabeta T cells secrete cytokines that initiate immunoglobulin (Ig) class switching from IgM to IgG. In this study, we show that formalin-inactivated influenza PR8 virus induces virus-specific IgM and IgG responses in the absence of CD4(+) T cells and that all four subclasses of IgG are produced. The immunized CD4-deficient mice were also found to be completely protected against lethal infection with live, pathogenic influenza virus. The ability of CD4(+) T-cell-deficient mice to generate these IgG responses was not found to be impaired when these mice were depleted of CD8(+) T cells with an anti-CD8 monoclonal antibody. In contrast, alphabeta T-cell-deficient mice (TCRbeta(-/-)) were not found to produce significant amounts of IgG upon immunization with formalin-inactivated PR8 virus. These results suggest that CD4(-) CD8(-) double-negative alphabeta T cells are playing a role in regulating Ig class switching in the absence of CD4(+) T cells." @default.
• W2166851592 created "2016-06-24" @default.
• W2166851592 creator A5048179813 @default.
• W2166851592 creator A5064720448 @default.
• W2166851592 date "2000-06-01" @default.
• W2166851592 modified "2023-10-18" @default.
• W2166851592 title "Induction of CD4⁺T-Cell-Independent Immunoglobulin Responses by Inactivated Influenza Virus" @default.
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• W2166851592 doi "https://doi.org/10.1128/jvi.74.11.4999-5005.2000" @default.
• W2166851592 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/110851" @default.
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