FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166854166> ?p ?o ?g. }

• W2166854166 endingPage "8567" @default.
• W2166854166 startingPage "8562" @default.
• W2166854166 abstract "Myasthenia gravis (MG) is a neuromuscular transmission disorder in which damage to acetylcholine receptors (AChR) on motor endplates by autoantibody-induced complement attack causes muscle weakness. To determine whether and, if so, to what extent, blockade of complement cascade at the C5 step ameliorates disease, we evaluated the effect of administering a functionally blocking anti-C5 mAb in passive experimental MG in Lewis rats induced with AChR Ab McAb-3. In contrast to uniform severe weakness at 24 h requiring euthanasia in untreated animals, anti-C5 mAb-pretreated rats showed no weakness at 48 h. Anti-C5 mAb treatment 24 h after disease induction restored strength in two-thirds of the rats. Immunofluorescence staining of endplates from the treated animals showed that C9 deposition at AChR was reduced and ultrastructural analyses showed that endplates were intact. The results argue that targeting C5 may warrant testing in MG patients and that this approach may be particularly valuable for myasthenic crisis." @default.
• W2166854166 created "2016-06-24" @default.
• W2166854166 creator A5004438381 @default.
• W2166854166 creator A5033383333 @default.
• W2166854166 creator A5056580448 @default.
• W2166854166 creator A5064192826 @default.
• W2166854166 creator A5068116120 @default.
• W2166854166 creator A5085950278 @default.
• W2166854166 date "2007-12-15" @default.
• W2166854166 modified "2023-10-16" @default.
• W2166854166 title "Anti-C5 Antibody Treatment Ameliorates Weakness in Experimentally Acquired Myasthenia Gravis" @default.
• W2166854166 cites W1503660579 @default.
• W2166854166 cites W1561559732 @default.
• W2166854166 cites W1605218331 @default.
• W2166854166 cites W1975834355 @default.
• W2166854166 cites W1980994073 @default.
• W2166854166 cites W1981165346 @default.
• W2166854166 cites W1983404333 @default.
• W2166854166 cites W1983627336 @default.
• W2166854166 cites W1995881043 @default.
• W2166854166 cites W2009143978 @default.
• W2166854166 cites W2023377972 @default.
• W2166854166 cites W2026130611 @default.
• W2166854166 cites W2026370029 @default.
• W2166854166 cites W2042024537 @default.
• W2166854166 cites W2043167284 @default.
• W2166854166 cites W2068030815 @default.
• W2166854166 cites W2071654790 @default.
• W2166854166 cites W2073884307 @default.
• W2166854166 cites W2085694694 @default.
• W2166854166 cites W2090025607 @default.
• W2166854166 cites W2096621381 @default.
• W2166854166 cites W2103084622 @default.
• W2166854166 cites W2110540991 @default.
• W2166854166 cites W2130071037 @default.
• W2166854166 cites W2154760595 @default.
• W2166854166 cites W2161320987 @default.
• W2166854166 cites W2331818774 @default.
• W2166854166 cites W2397656328 @default.
• W2166854166 cites W4239521277 @default.
• W2166854166 doi "https://doi.org/10.4049/jimmunol.179.12.8562" @default.
• W2166854166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18056404" @default.
• W2166854166 hasPublicationYear "2007" @default.
• W2166854166 type Work @default.
• W2166854166 sameAs 2166854166 @default.
• W2166854166 citedByCount "71" @default.
• W2166854166 countsByYear W21668541662012 @default.
• W2166854166 countsByYear W21668541662013 @default.
• W2166854166 countsByYear W21668541662015 @default.
• W2166854166 countsByYear W21668541662016 @default.
• W2166854166 countsByYear W21668541662017 @default.
• W2166854166 countsByYear W21668541662018 @default.
• W2166854166 countsByYear W21668541662019 @default.
• W2166854166 countsByYear W21668541662020 @default.
• W2166854166 countsByYear W21668541662021 @default.
• W2166854166 countsByYear W21668541662022 @default.
• W2166854166 countsByYear W21668541662023 @default.
• W2166854166 crossrefType "journal-article" @default.
• W2166854166 hasAuthorship W2166854166A5004438381 @default.
• W2166854166 hasAuthorship W2166854166A5033383333 @default.
• W2166854166 hasAuthorship W2166854166A5056580448 @default.
• W2166854166 hasAuthorship W2166854166A5064192826 @default.
• W2166854166 hasAuthorship W2166854166A5068116120 @default.
• W2166854166 hasAuthorship W2166854166A5085950278 @default.
• W2166854166 hasBestOaLocation W21668541661 @default.
• W2166854166 hasConcept C105702510 @default.
• W2166854166 hasConcept C111684460 @default.
• W2166854166 hasConcept C126322002 @default.
• W2166854166 hasConcept C142724271 @default.
• W2166854166 hasConcept C159654299 @default.
• W2166854166 hasConcept C163764329 @default.
• W2166854166 hasConcept C169760540 @default.
• W2166854166 hasConcept C170493617 @default.
• W2166854166 hasConcept C203014093 @default.
• W2166854166 hasConcept C2775910092 @default.
• W2166854166 hasConcept C2776418732 @default.
• W2166854166 hasConcept C2777240379 @default.
• W2166854166 hasConcept C2778105408 @default.
• W2166854166 hasConcept C2778236600 @default.
• W2166854166 hasConcept C2780247198 @default.
• W2166854166 hasConcept C2909770972 @default.
• W2166854166 hasConcept C3020341438 @default.
• W2166854166 hasConcept C542903549 @default.
• W2166854166 hasConcept C71924100 @default.
• W2166854166 hasConcept C80161118 @default.
• W2166854166 hasConcept C86803240 @default.
• W2166854166 hasConceptScore W2166854166C105702510 @default.
• W2166854166 hasConceptScore W2166854166C111684460 @default.
• W2166854166 hasConceptScore W2166854166C126322002 @default.
• W2166854166 hasConceptScore W2166854166C142724271 @default.
• W2166854166 hasConceptScore W2166854166C159654299 @default.
• W2166854166 hasConceptScore W2166854166C163764329 @default.
• W2166854166 hasConceptScore W2166854166C169760540 @default.
• W2166854166 hasConceptScore W2166854166C170493617 @default.
• W2166854166 hasConceptScore W2166854166C203014093 @default.
• W2166854166 hasConceptScore W2166854166C2775910092 @default.
• W2166854166 hasConceptScore W2166854166C2776418732 @default.
• W2166854166 hasConceptScore W2166854166C2777240379 @default.

• next