FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166861142> ?p ?o ?g. }

• W2166861142 endingPage "4950" @default.
• W2166861142 startingPage "4941" @default.
• W2166861142 abstract "The success of immunotherapy for the treatment of metastatic cancer is contingent on the identification of appropriate target antigens. Potential targets must be expressed on tumors but show restricted expression on normal tissues. To maximize patient eligibility, ideal target antigens should be expressed on a high percentage of tumors within a histology and, potentially, in multiple different malignancies.A Nanostring probeset was designed containing 97 genes, 72 of which are considered potential candidate genes for immunotherapy. Five established melanoma cell lines, 59 resected metastatic melanoma tumors, and 31 normal tissue samples were profiled and analyzed using Nanostring technology.Of the 72 potential target genes, 33 were overexpressed in more than 20% of studied melanoma tumor samples. Twenty of those genes were identified as differentially expressed between normal tissues and tumor samples by ANOVA analysis. Analysis of normal tissue gene expression identified seven genes with limited normal tissue expression that warrant further consideration as potential immunotherapy target antigens: CSAG2, MAGEA3, MAGEC2, IL13RA2, PRAME, CSPG4, and SOX10. These genes were highly overexpressed on a large percentage of the studied tumor samples, with expression in a limited number of normal tissue samples at much lower levels.The application of Nanostring RNA counting technology was used to directly quantitate the gene expression levels of multiple potential tumor antigens. Analysis of cell lines, 59 tumors, and normal tissues identified seven potential immunotherapy targets for the treatment of melanoma that could increase the number of patients potentially eligible for adoptive immunotherapy." @default.
• W2166861142 created "2016-06-24" @default.
• W2166861142 creator A5007176418 @default.
• W2166861142 creator A5025443654 @default.
• W2166861142 creator A5028956946 @default.
• W2166861142 creator A5058516855 @default.
• W2166861142 creator A5072133376 @default.
• W2166861142 creator A5076345876 @default.
• W2166861142 creator A5078177020 @default.
• W2166861142 date "2013-09-15" @default.
• W2166861142 modified "2023-10-13" @default.
• W2166861142 title "Gene Expression Profiling using Nanostring Digital RNA Counting to Identify Potential Target Antigens for Melanoma Immunotherapy" @default.
• W2166861142 cites W1944166248 @default.
• W2166861142 cites W1963522404 @default.
• W2166861142 cites W1971826820 @default.
• W2166861142 cites W1981417548 @default.
• W2166861142 cites W1985577088 @default.
• W2166861142 cites W1985946321 @default.
• W2166861142 cites W1987223917 @default.
• W2166861142 cites W1991584436 @default.
• W2166861142 cites W1993191461 @default.
• W2166861142 cites W1995830102 @default.
• W2166861142 cites W2015680846 @default.
• W2166861142 cites W2019668843 @default.
• W2166861142 cites W2022273648 @default.
• W2166861142 cites W2038466229 @default.
• W2166861142 cites W2040804076 @default.
• W2166861142 cites W2050302632 @default.
• W2166861142 cites W2066311819 @default.
• W2166861142 cites W2066985179 @default.
• W2166861142 cites W2070748533 @default.
• W2166861142 cites W2071825091 @default.
• W2166861142 cites W2072709919 @default.
• W2166861142 cites W2074639636 @default.
• W2166861142 cites W2079402310 @default.
• W2166861142 cites W2081232984 @default.
• W2166861142 cites W2084152268 @default.
• W2166861142 cites W2086882683 @default.
• W2166861142 cites W2089798367 @default.
• W2166861142 cites W2092701673 @default.
• W2166861142 cites W2098688170 @default.
• W2166861142 cites W2099156986 @default.
• W2166861142 cites W2100841018 @default.
• W2166861142 cites W2101485657 @default.
• W2166861142 cites W2107398514 @default.
• W2166861142 cites W2112965064 @default.
• W2166861142 cites W2113136054 @default.
• W2166861142 cites W2122465970 @default.
• W2166861142 cites W2130011407 @default.
• W2166861142 cites W2135456661 @default.
• W2166861142 cites W2141413204 @default.
• W2166861142 cites W2141463948 @default.
• W2166861142 cites W2144814137 @default.
• W2166861142 cites W2145290079 @default.
• W2166861142 cites W2150032631 @default.
• W2166861142 cites W2150065276 @default.
• W2166861142 cites W2153712501 @default.
• W2166861142 cites W2153965826 @default.
• W2166861142 cites W2161335936 @default.
• W2166861142 cites W2165079404 @default.
• W2166861142 cites W2407861763 @default.
• W2166861142 cites W2416259400 @default.
• W2166861142 doi "https://doi.org/10.1158/1078-0432.ccr-13-1253" @default.
• W2166861142 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3778100" @default.
• W2166861142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24021875" @default.
• W2166861142 hasPublicationYear "2013" @default.
• W2166861142 type Work @default.
• W2166861142 sameAs 2166861142 @default.
• W2166861142 citedByCount "49" @default.
• W2166861142 countsByYear W21668611422014 @default.
• W2166861142 countsByYear W21668611422015 @default.
• W2166861142 countsByYear W21668611422016 @default.
• W2166861142 countsByYear W21668611422017 @default.
• W2166861142 countsByYear W21668611422018 @default.
• W2166861142 countsByYear W21668611422019 @default.
• W2166861142 countsByYear W21668611422020 @default.
• W2166861142 countsByYear W21668611422021 @default.
• W2166861142 countsByYear W21668611422022 @default.
• W2166861142 countsByYear W21668611422023 @default.
• W2166861142 crossrefType "journal-article" @default.
• W2166861142 hasAuthorship W2166861142A5007176418 @default.
• W2166861142 hasAuthorship W2166861142A5025443654 @default.
• W2166861142 hasAuthorship W2166861142A5028956946 @default.
• W2166861142 hasAuthorship W2166861142A5058516855 @default.
• W2166861142 hasAuthorship W2166861142A5072133376 @default.
• W2166861142 hasAuthorship W2166861142A5076345876 @default.
• W2166861142 hasAuthorship W2166861142A5078177020 @default.
• W2166861142 hasBestOaLocation W21668611421 @default.
• W2166861142 hasConcept C104317684 @default.
• W2166861142 hasConcept C121608353 @default.
• W2166861142 hasConcept C147483822 @default.
• W2166861142 hasConcept C150194340 @default.
• W2166861142 hasConcept C18431079 @default.
• W2166861142 hasConcept C203014093 @default.
• W2166861142 hasConcept C2777658100 @default.
• W2166861142 hasConcept C2777701055 @default.
• W2166861142 hasConcept C2780674031 @default.
• W2166861142 hasConcept C502942594 @default.

• next