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- W2166862904 endingPage "48" @default.
- W2166862904 startingPage "40" @default.
- W2166862904 abstract "T follicular helper (TFH) cells are essential for formation of germinal centres (GCs) and selection of mutated GC B cells. It has become clear over the last decade that precise control of TFH cell numbers is important to produce optimally affinity-matured antibody responses that are devoid of self-reactivity. Indeed, limiting the number of TFH cells appears important to impose competition amongst B-cell clones and set a selection threshold that will favour survival of high affinity clones. In contrast, excessive number of TFH cells appears to lower the selection threshold and allow survival of low affinity or self-reactive clones. Here, we review the cell-intrinsic and cell-extrinsic mechanisms that influence TFH cell homeostasis, including recent insights into novel modes of regulation by T-cell costimulators, toxic metabolites, microRNAs, RNA-binding proteins and regulatory cells." @default.
- W2166862904 created "2016-06-24" @default.
- W2166862904 creator A5035197878 @default.
- W2166862904 creator A5089715068 @default.
- W2166862904 date "2013-11-05" @default.
- W2166862904 modified "2023-10-01" @default.
- W2166862904 title "Control of TFH cell numbers: why and how?" @default.
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