FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166865736> ?p ?o ?g. }

• W2166865736 endingPage "443" @default.
• W2166865736 startingPage "438" @default.
• W2166865736 abstract "Objective: The management of patients with non-small cell lung cancer (NSCLC) with intrapulmonary metastases (PM) is controversial. In TNM classification, PM are designed as T4 when in the same lobe of the primary tumour (PM1) and M1 when in a different lobe(s) (PM2). Some authors have questioned the negative prognostic impact of PM. The present study assessed prevalence, correlation with clinico-pathologic variables and impact on survival of PM, along with a review of the literature. Methods: From January 1993 to December 2006, 2013 NSCLC patients underwent surgical resection at our institution. Of these, 74 presented with PM (39 PM1, 35 PM2). Patients with bronchioloalveolar carcinoma (BAC), carcinoid tumours, contralateral disease and preoperative chemo/radiotherapy were excluded from the analysis. A logistic regression analysis was undertaken to evaluate a relationship between the presence of PM and different clinico-pathologic variables. Survival analysis was undertaken to investigate the prognostic significance of PM. Results: PM represent 3.6% of our patient population of operated NSCLC. Metastases were multiple in 36 cases and single in 38. Thirty-six patients had node-negative disease. Among all the variables for the logistic regression analysis only vascular invasion (OR: 0. 45; 95% CI 0.24–0.85, p = 0.01) and N status (OR: 0. 6; 95% CI 0.43–0.82, p = 0.001) were significantly correlated with the presence of PM. Median survival rates of PM1, PM2, other T4 and other M1 patients were 25, 23, 15 and 14 months, respectively. A survival advantage was observed in patients with PM as compared to other T4/M1 patients, although the difference was not significant either overall (p = 0.21) or in the N0 disease group (p = 0.12). Conclusions: The presence of PM in NSCLC patients is a rare occurrence. Risk factors for the development of PM are a microscopic vascular invasion and a high nodal status. A survival advantage over other T4/M1 patients is evident from our experience, although not significant. The results of the literature which have been accumulating in the most recent years including ours bend to the conclusion that there is sufficient validated information to consider a downstaging in the presence of intrapulmonary metastases from NSCLC for the seventh edition of the TNM classification." @default.
• W2166865736 created "2016-06-24" @default.
• W2166865736 creator A5006895694 @default.
• W2166865736 creator A5030208494 @default.
• W2166865736 creator A5032489768 @default.
• W2166865736 creator A5035239052 @default.
• W2166865736 creator A5048891794 @default.
• W2166865736 creator A5050204953 @default.
• W2166865736 creator A5074958122 @default.
• W2166865736 creator A5089627170 @default.
• W2166865736 date "2008-08-01" @default.
• W2166865736 modified "2023-10-05" @default.
• W2166865736 title "The significance of intrapulmonary metastasis in non-small cell lung cancer: upstaging or downstaging? A re-appraisal for the next TNM staging system☆" @default.
• W2166865736 cites W1158033259 @default.
• W2166865736 cites W1626500208 @default.
• W2166865736 cites W1710915557 @default.
• W2166865736 cites W1972209863 @default.
• W2166865736 cites W1979300931 @default.
• W2166865736 cites W2005886118 @default.
• W2166865736 cites W2014546505 @default.
• W2166865736 cites W2021791101 @default.
• W2166865736 cites W2022784448 @default.
• W2166865736 cites W2053697638 @default.
• W2166865736 cites W2066013101 @default.
• W2166865736 cites W2090259947 @default.
• W2166865736 cites W2090261268 @default.
• W2166865736 cites W2092936234 @default.
• W2166865736 cites W2093335481 @default.
• W2166865736 cites W2094828892 @default.
• W2166865736 cites W2124824275 @default.
• W2166865736 cites W2159209309 @default.
• W2166865736 cites W2166812357 @default.
• W2166865736 cites W2405180546 @default.
• W2166865736 cites W2414551104 @default.
• W2166865736 cites W55987916 @default.
• W2166865736 doi "https://doi.org/10.1016/j.ejcts.2008.03.070" @default.
• W2166865736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18502660" @default.
• W2166865736 hasPublicationYear "2008" @default.
• W2166865736 type Work @default.
• W2166865736 sameAs 2166865736 @default.
• W2166865736 citedByCount "33" @default.
• W2166865736 countsByYear W21668657362012 @default.
• W2166865736 countsByYear W21668657362013 @default.
• W2166865736 countsByYear W21668657362014 @default.
• W2166865736 countsByYear W21668657362015 @default.
• W2166865736 countsByYear W21668657362016 @default.
• W2166865736 countsByYear W21668657362017 @default.
• W2166865736 countsByYear W21668657362018 @default.
• W2166865736 countsByYear W21668657362019 @default.
• W2166865736 countsByYear W21668657362021 @default.
• W2166865736 countsByYear W21668657362022 @default.
• W2166865736 crossrefType "journal-article" @default.
• W2166865736 hasAuthorship W2166865736A5006895694 @default.
• W2166865736 hasAuthorship W2166865736A5030208494 @default.
• W2166865736 hasAuthorship W2166865736A5032489768 @default.
• W2166865736 hasAuthorship W2166865736A5035239052 @default.
• W2166865736 hasAuthorship W2166865736A5048891794 @default.
• W2166865736 hasAuthorship W2166865736A5050204953 @default.
• W2166865736 hasAuthorship W2166865736A5074958122 @default.
• W2166865736 hasAuthorship W2166865736A5089627170 @default.
• W2166865736 hasBestOaLocation W21668657361 @default.
• W2166865736 hasConcept C121608353 @default.
• W2166865736 hasConcept C126322002 @default.
• W2166865736 hasConcept C126838900 @default.
• W2166865736 hasConcept C141071460 @default.
• W2166865736 hasConcept C143998085 @default.
• W2166865736 hasConcept C146357865 @default.
• W2166865736 hasConcept C151730666 @default.
• W2166865736 hasConcept C151956035 @default.
• W2166865736 hasConcept C2776256026 @default.
• W2166865736 hasConcept C2777546739 @default.
• W2166865736 hasConcept C2780091936 @default.
• W2166865736 hasConcept C2908647359 @default.
• W2166865736 hasConcept C509974204 @default.
• W2166865736 hasConcept C71924100 @default.
• W2166865736 hasConcept C86803240 @default.
• W2166865736 hasConcept C99454951 @default.
• W2166865736 hasConceptScore W2166865736C121608353 @default.
• W2166865736 hasConceptScore W2166865736C126322002 @default.
• W2166865736 hasConceptScore W2166865736C126838900 @default.
• W2166865736 hasConceptScore W2166865736C141071460 @default.
• W2166865736 hasConceptScore W2166865736C143998085 @default.
• W2166865736 hasConceptScore W2166865736C146357865 @default.
• W2166865736 hasConceptScore W2166865736C151730666 @default.
• W2166865736 hasConceptScore W2166865736C151956035 @default.
• W2166865736 hasConceptScore W2166865736C2776256026 @default.
• W2166865736 hasConceptScore W2166865736C2777546739 @default.
• W2166865736 hasConceptScore W2166865736C2780091936 @default.
• W2166865736 hasConceptScore W2166865736C2908647359 @default.
• W2166865736 hasConceptScore W2166865736C509974204 @default.
• W2166865736 hasConceptScore W2166865736C71924100 @default.
• W2166865736 hasConceptScore W2166865736C86803240 @default.
• W2166865736 hasConceptScore W2166865736C99454951 @default.
• W2166865736 hasIssue "2" @default.
• W2166865736 hasLocation W21668657361 @default.
• W2166865736 hasLocation W21668657362 @default.
• W2166865736 hasOpenAccess W2166865736 @default.
• W2166865736 hasPrimaryLocation W21668657361 @default.

• next