FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166874963> ?p ?o ?g. }

• W2166874963 endingPage "48" @default.
• W2166874963 startingPage "43" @default.
• W2166874963 abstract "Although considerable evidence exists on the efficacy of lithium as an augmenting agent in refractory depression, the underlying neurobiology of this phenomenon is unknown. In patients with major depression, changes of the hypothalamic-pituitary-adrenocortical (HPA) system have been detected by means of the dexamethasone suppression test (DST), when administered during treatment with tricyclic antidepressants. We investigated whether the DST also reveals alterations of the HPA system during lithium augmentation. We also sought to identify whether response to lithium augmentation can be predicted with the DST. Twenty-five patients with unipolar major depression, who did not respond to an adequate antidepressant monotherapy of at least 4 weeks, were measured for basal (pre-dexamethasone, 0800h) cortisol and ACTH levels and were administered the DST the day before initiation of lithium augmentation treatment. The same neuroendocrine procedures were repeated after 3 to 4 weeks. Criteria of response to lithium augmentation, defined as a reduction of the Hamilton Depression Rating Scale (HDRS17) score by ≥50% and an end point score of 9 or less, were determined by weekly HDRS ratings. The DST revealed a statistically significant increase of the post-dexamethasone cortisol values (P=0.021) and an increase in the post-dexamethasone ACTH values (P=0.051) during lithium augmentation as compared to pre-treatment baseline evaluations. The pre-dexamethasone hormone values were unchanged. The number of non-suppressors at baseline was one and increased to three at follow-up. Results of DST did not predict response to lithium augmentation, which occurred in 40% of subjects. Results suggest that lithium augmentation increases HPA system activity, as indicated by the increase of post-dexamethasone cortisol and ACTH levels measured by the DST. This is in contrast to the established decline of HPA system activity during treatment with tricyclic antidepressants. Depression and Anxiety 17:43–48, 2003. © 2003 Wiley-Liss, Inc." @default.
• W2166874963 created "2016-06-24" @default.
• W2166874963 creator A5005271615 @default.
• W2166874963 creator A5027622689 @default.
• W2166874963 creator A5028686171 @default.
• W2166874963 creator A5032572246 @default.
• W2166874963 creator A5041397944 @default.
• W2166874963 creator A5044042153 @default.
• W2166874963 creator A5073762805 @default.
• W2166874963 creator A5074716536 @default.
• W2166874963 date "2003-01-01" @default.
• W2166874963 modified "2023-10-02" @default.
• W2166874963 title "Lithium augmentation increases post-dexamethasone cortisol in the dexamethasone suppression test in unipolar major depression" @default.
• W2166874963 cites W1607918370 @default.
• W2166874963 cites W1794165588 @default.
• W2166874963 cites W1840450113 @default.
• W2166874963 cites W1968700541 @default.
• W2166874963 cites W1972122225 @default.
• W2166874963 cites W1973534109 @default.
• W2166874963 cites W1982015769 @default.
• W2166874963 cites W1984914394 @default.
• W2166874963 cites W1988049829 @default.
• W2166874963 cites W1994589587 @default.
• W2166874963 cites W2018195755 @default.
• W2166874963 cites W2035005710 @default.
• W2166874963 cites W2046613341 @default.
• W2166874963 cites W2057250626 @default.
• W2166874963 cites W2081165500 @default.
• W2166874963 cites W2083597120 @default.
• W2166874963 cites W2114613490 @default.
• W2166874963 cites W2121728343 @default.
• W2166874963 cites W2155275341 @default.
• W2166874963 cites W2405219202 @default.
• W2166874963 doi "https://doi.org/10.1002/da.10078" @default.
• W2166874963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12577277" @default.
• W2166874963 hasPublicationYear "2003" @default.
• W2166874963 type Work @default.
• W2166874963 sameAs 2166874963 @default.
• W2166874963 citedByCount "23" @default.
• W2166874963 countsByYear W21668749632015 @default.
• W2166874963 countsByYear W21668749632017 @default.
• W2166874963 countsByYear W21668749632019 @default.
• W2166874963 crossrefType "journal-article" @default.
• W2166874963 hasAuthorship W2166874963A5005271615 @default.
• W2166874963 hasAuthorship W2166874963A5027622689 @default.
• W2166874963 hasAuthorship W2166874963A5028686171 @default.
• W2166874963 hasAuthorship W2166874963A5032572246 @default.
• W2166874963 hasAuthorship W2166874963A5041397944 @default.
• W2166874963 hasAuthorship W2166874963A5044042153 @default.
• W2166874963 hasAuthorship W2166874963A5073762805 @default.
• W2166874963 hasAuthorship W2166874963A5074716536 @default.
• W2166874963 hasBestOaLocation W21668749631 @default.
• W2166874963 hasConcept C126322002 @default.
• W2166874963 hasConcept C134018914 @default.
• W2166874963 hasConcept C138496976 @default.
• W2166874963 hasConcept C139719470 @default.
• W2166874963 hasConcept C15744967 @default.
• W2166874963 hasConcept C162324750 @default.
• W2166874963 hasConcept C2776867660 @default.
• W2166874963 hasConcept C2778541603 @default.
• W2166874963 hasConcept C2778709874 @default.
• W2166874963 hasConcept C2779177272 @default.
• W2166874963 hasConcept C2780401358 @default.
• W2166874963 hasConcept C2780455818 @default.
• W2166874963 hasConcept C2781081902 @default.
• W2166874963 hasConcept C2781161787 @default.
• W2166874963 hasConcept C71924100 @default.
• W2166874963 hasConcept C83849319 @default.
• W2166874963 hasConcept C98274493 @default.
• W2166874963 hasConceptScore W2166874963C126322002 @default.
• W2166874963 hasConceptScore W2166874963C134018914 @default.
• W2166874963 hasConceptScore W2166874963C138496976 @default.
• W2166874963 hasConceptScore W2166874963C139719470 @default.
• W2166874963 hasConceptScore W2166874963C15744967 @default.
• W2166874963 hasConceptScore W2166874963C162324750 @default.
• W2166874963 hasConceptScore W2166874963C2776867660 @default.
• W2166874963 hasConceptScore W2166874963C2778541603 @default.
• W2166874963 hasConceptScore W2166874963C2778709874 @default.
• W2166874963 hasConceptScore W2166874963C2779177272 @default.
• W2166874963 hasConceptScore W2166874963C2780401358 @default.
• W2166874963 hasConceptScore W2166874963C2780455818 @default.
• W2166874963 hasConceptScore W2166874963C2781081902 @default.
• W2166874963 hasConceptScore W2166874963C2781161787 @default.
• W2166874963 hasConceptScore W2166874963C71924100 @default.
• W2166874963 hasConceptScore W2166874963C83849319 @default.
• W2166874963 hasConceptScore W2166874963C98274493 @default.
• W2166874963 hasIssue "1" @default.
• W2166874963 hasLocation W21668749631 @default.
• W2166874963 hasLocation W21668749632 @default.
• W2166874963 hasOpenAccess W2166874963 @default.
• W2166874963 hasPrimaryLocation W21668749631 @default.
• W2166874963 hasRelatedWork W1976035881 @default.
• W2166874963 hasRelatedWork W1976129656 @default.
• W2166874963 hasRelatedWork W2018087789 @default.
• W2166874963 hasRelatedWork W2019972925 @default.
• W2166874963 hasRelatedWork W2052065831 @default.
• W2166874963 hasRelatedWork W2056435782 @default.
• W2166874963 hasRelatedWork W2091479231 @default.

• next