Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166897817> ?p ?o ?g. }
- W2166897817 endingPage "804" @default.
- W2166897817 startingPage "795" @default.
- W2166897817 abstract "Nerve growth factor (NGF) in mouse submandibular glands (SGs) is generated from a 35-kD precursor by proteolytic enzymes that have yet to be identified. Prohormone convertases (PCs) cleave the NGF precursor in vitro, and in this study we questioned whether PCs could process salivary NGF in vivo. mRNA coding for PC2 (but not PC1) was detected on Northern blots of SG mRNA and also by in situ hybridization within parasympathetic neurons of intralobular ganglia. Northern blot and in situ hybridization analyses also detect mRNA coding for furin. In SGs of male mice, furin mRNA levels are high at birth and remain high throughout development. In glands from female mice, levels decline during postnatal development and are lower in adults than in newborns. Immunocytochemistry detects furin immunoreactivity in pro-acinar and ductal cells of glands from newborn and pubescent mice. In glands of adults, furin immunoreactivity is detectable in acinar cells but highest levels are present in NGF-containing granular convoluted tubule cells. These data, taken together with those from previous studies, suggest that furin is a candidate processing enzyme for NGF in mouse submandibular glands." @default.
- W2166897817 created "2016-06-24" @default.
- W2166897817 creator A5003118319 @default.
- W2166897817 creator A5009368039 @default.
- W2166897817 creator A5032885483 @default.
- W2166897817 creator A5045820469 @default.
- W2166897817 creator A5061780796 @default.
- W2166897817 creator A5078379123 @default.
- W2166897817 creator A5078845932 @default.
- W2166897817 creator A5090659741 @default.
- W2166897817 date "1997-06-01" @default.
- W2166897817 modified "2023-10-04" @default.
- W2166897817 title "Prohormone Convertases in Mouse Submandibular Gland: Co-localization of Furin and Nerve Growth Factor" @default.
- W2166897817 cites W1491571478 @default.
- W2166897817 cites W1501424340 @default.
- W2166897817 cites W1503569939 @default.
- W2166897817 cites W1518294496 @default.
- W2166897817 cites W1590264526 @default.
- W2166897817 cites W1593390085 @default.
- W2166897817 cites W1593538742 @default.
- W2166897817 cites W1601462184 @default.
- W2166897817 cites W1749453950 @default.
- W2166897817 cites W1796210158 @default.
- W2166897817 cites W1880716631 @default.
- W2166897817 cites W1888826666 @default.
- W2166897817 cites W1937327614 @default.
- W2166897817 cites W1968189814 @default.
- W2166897817 cites W1970742397 @default.
- W2166897817 cites W1975096426 @default.
- W2166897817 cites W1976443648 @default.
- W2166897817 cites W1997438820 @default.
- W2166897817 cites W2004693684 @default.
- W2166897817 cites W2007842896 @default.
- W2166897817 cites W2008157672 @default.
- W2166897817 cites W2023640485 @default.
- W2166897817 cites W2025861142 @default.
- W2166897817 cites W2043328403 @default.
- W2166897817 cites W2050833231 @default.
- W2166897817 cites W2051949327 @default.
- W2166897817 cites W2055536996 @default.
- W2166897817 cites W2061824832 @default.
- W2166897817 cites W2062260804 @default.
- W2166897817 cites W2070712835 @default.
- W2166897817 cites W2074138321 @default.
- W2166897817 cites W2074144850 @default.
- W2166897817 cites W2075632548 @default.
- W2166897817 cites W2077052406 @default.
- W2166897817 cites W2077400067 @default.
- W2166897817 cites W2081648532 @default.
- W2166897817 cites W2082012658 @default.
- W2166897817 cites W2099301076 @default.
- W2166897817 cites W2099336487 @default.
- W2166897817 cites W2110458761 @default.
- W2166897817 cites W2113429450 @default.
- W2166897817 cites W96950780 @default.
- W2166897817 doi "https://doi.org/10.1177/002215549704500604" @default.
- W2166897817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9199665" @default.
- W2166897817 hasPublicationYear "1997" @default.
- W2166897817 type Work @default.
- W2166897817 sameAs 2166897817 @default.
- W2166897817 citedByCount "19" @default.
- W2166897817 countsByYear W21668978172016 @default.
- W2166897817 countsByYear W21668978172021 @default.
- W2166897817 crossrefType "journal-article" @default.
- W2166897817 hasAuthorship W2166897817A5003118319 @default.
- W2166897817 hasAuthorship W2166897817A5009368039 @default.
- W2166897817 hasAuthorship W2166897817A5032885483 @default.
- W2166897817 hasAuthorship W2166897817A5045820469 @default.
- W2166897817 hasAuthorship W2166897817A5061780796 @default.
- W2166897817 hasAuthorship W2166897817A5078379123 @default.
- W2166897817 hasAuthorship W2166897817A5078845932 @default.
- W2166897817 hasAuthorship W2166897817A5090659741 @default.
- W2166897817 hasConcept C104317684 @default.
- W2166897817 hasConcept C105580179 @default.
- W2166897817 hasConcept C126322002 @default.
- W2166897817 hasConcept C134018914 @default.
- W2166897817 hasConcept C150903083 @default.
- W2166897817 hasConcept C153911025 @default.
- W2166897817 hasConcept C170493617 @default.
- W2166897817 hasConcept C177707886 @default.
- W2166897817 hasConcept C181199279 @default.
- W2166897817 hasConcept C207001950 @default.
- W2166897817 hasConcept C2777265534 @default.
- W2166897817 hasConcept C2778148616 @default.
- W2166897817 hasConcept C2778163477 @default.
- W2166897817 hasConcept C2778423431 @default.
- W2166897817 hasConcept C2778764654 @default.
- W2166897817 hasConcept C2780072125 @default.
- W2166897817 hasConcept C2780090379 @default.
- W2166897817 hasConcept C2780266248 @default.
- W2166897817 hasConcept C2908627167 @default.
- W2166897817 hasConcept C2910756308 @default.
- W2166897817 hasConcept C35866371 @default.
- W2166897817 hasConcept C43554185 @default.
- W2166897817 hasConcept C55493867 @default.
- W2166897817 hasConcept C71315377 @default.
- W2166897817 hasConcept C71924100 @default.
- W2166897817 hasConcept C81439078 @default.