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• W2166907029 abstract "La punción transbronquial guiada por ecoendoscopia permite obtener bloques celulares a partir del material de punción. Nuestro objetivo fue analizar su contribución al diagnóstico citológico convencional. Revisión retrospectiva de las punciones por ecobroncoscopia realizadas de forma consecutiva durante 2 años con diagnóstico específico. Se analizó la capacidad de generar bloques celulares, su contribución al diagnóstico y a la realización de técnicas de inmunohistoquímica. Se revisaron 129 muestras de lesiones correspondientes a 110 pacientes. En el 91% el diagnóstico fue de malignidad. Las lesiones puncionadas más frecuentemente fueron las adenopatías 4R (28%) y subcarinal (21%). El 72% de las muestras se procesaron como bloque celular, siendo su capacidad para realizar técnicas de inmunohistoquímica significativamente mayor a la de las muestras citológicas (52,6% vs. 14%, p < 0,0001). En 4 casos el bloque permitió un diagnóstico morfológico exclusivo (3 sarcoidosis y una metástasis de adenocarcinoma prostático) y en 3 carcinomas definir el subtipo y origen. El diagnóstico exclusivo mediante bloque celular fue significativamente más frecuente en la patología benigna que en la maligna (25% vs. 0,9%, p = 0,002). La obtención de bloque celular a partir de muestras de punción por ecobroncoscopia fue del 72%. Sus principales aportaciones fueron la mejora del diagnóstico de lesiones benignas y la capacidad para realizar técnicas de inmunohistoquímica cuya contribución es esencial para la tipificación de neoplasias. Cell block material from puncture can be obtained with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in many cases. The aim of this study was to analyse the value of additional information from cell blocks obtained with EBUS-TBNA samples from mediastinal and hilar lymph nodes and masses. Review of pathology reports with a specific diagnosis obtained from EBUS-TBNA samples of mediastinal or hilar lesions, prospectively obtained over a two-year period. The generation of cell blocks from cytology needle samples, the contribution to morphological diagnosis, and the possible use of samples for immunohistochemistry were analysed. One hundred and twenty-nine samples corresponding to 110 patients were reviewed. The diagnosis was lung cancer in 81% of cases, extrapulmonary carcinoma in 10%, sarcoidosis in 4%, lymphoma in 2.7%, and tuberculosis in 0.9%. Cell blocks could be obtained in 72% of cases. Immunohistochemistry studies on the cell blocks were significantly easier to perform than on conventional smears (52.6% vs. 14%, P < .0001). In 4 cases, the cell block provided an exclusive morphological diagnosis (3 sarcoidosis and one metastasis from prostatic carcinoma) and in 3 carcinomas, subtype and origin could be identified. Exclusive diagnoses from the cell block were significantly more frequent in benign disease than in malignant disease (25% vs 0.9%, P = .002). Cell blocks were obtained from 72% of EBUS-TBNA diagnostic procedures. The main contributions of cell blocks to pathology examinations were the possibility of carrying out immunohistochemical staining for the better classification of neoplasms, especially extrapulmonary metastatic tumours, and the improved diagnosis of benign lesions." @default.
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• W2166907029 date "2014-07-01" @default.
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• W2166907029 title "Aportación del bloque celular en el diagnóstico de adenopatías y masas mediastínicas o hiliares realizado por ecobroncoscopia" @default.
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• W2166907029 doi "https://doi.org/10.1016/j.arbres.2013.11.022" @default.
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