Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166910080> ?p ?o ?g. }
- W2166910080 abstract "Background: As children with velocardiofacial syndrome (VCFS) develop, they are at increased risk for psychopathology; one third will eventually develop schizophrenia. Because VCFS and the concomitant symptomatology result from a known genetic origin, the biological and behavioral characteristics of the syndrome provide an optimal framework for conceptualizing the associations among genes, brain development, and behavior. The purpose of this study was to investigate the effect of the parental origin of the 22q11.2 microdeletion on the brain development of children and adolescents with VCFS. Methods: Eighteen persons with VCFS and 18 normal control subjects were matched individually for age and sex. Results of DNA polymorphism analyses determined the parental origin of the deletion. Nine persons with VCFS had a deletion on the maternally derived chromosome 22; 9 persons, on the paternally derived chromosome 22. High-resolution magnetic resonance imaging scans were analyzed to provide quantitative measures of gray and white matter brain tissue. Results: Total brain volume was approximately 11% smaller in the VCFS group than in controls. Comparisons between VCFS subgroups (maternal vs paternal microdeletion 22q11.2) indicated a significant 9% volumetric difference in total volume of cerebral gray matter (volume was greater in patients with paternal microdeletion) but not cerebral white matter. Significant age-related changes in gray matter were detected for subjects whose 22q11.2 deletion was on the maternal chromosome. Conclusions: Children and adolescents with VCFS experience major alterations in brain volumes. Significant reduction in gray matter development is attributable to presence of 22q11.2 microdeletion on the maternal chromosome. Arch Gen Psychiatry. 2001;58:64-68" @default.
- W2166910080 created "2016-06-24" @default.
- W2166910080 creator A5001083315 @default.
- W2166910080 creator A5040553801 @default.
- W2166910080 creator A5046688401 @default.
- W2166910080 creator A5060966201 @default.
- W2166910080 creator A5069858660 @default.
- W2166910080 date "2015-01-01" @default.
- W2166910080 modified "2023-09-27" @default.
- W2166910080 title "Parental Origin of the Deletion 22q11.2 and Brain Development in Velocardiofacial Syndrome" @default.
- W2166910080 cites W1490209070 @default.
- W2166910080 cites W1499894735 @default.
- W2166910080 cites W1604717232 @default.
- W2166910080 cites W18052369 @default.
- W2166910080 cites W1852307392 @default.
- W2166910080 cites W1882303649 @default.
- W2166910080 cites W1977995209 @default.
- W2166910080 cites W1978130180 @default.
- W2166910080 cites W1984772359 @default.
- W2166910080 cites W1996124672 @default.
- W2166910080 cites W1997489121 @default.
- W2166910080 cites W2000532324 @default.
- W2166910080 cites W2003756768 @default.
- W2166910080 cites W2025281664 @default.
- W2166910080 cites W2027537562 @default.
- W2166910080 cites W2027539256 @default.
- W2166910080 cites W2027671825 @default.
- W2166910080 cites W2038142183 @default.
- W2166910080 cites W2047264733 @default.
- W2166910080 cites W2051817607 @default.
- W2166910080 cites W2056435351 @default.
- W2166910080 cites W2058433521 @default.
- W2166910080 cites W2061829751 @default.
- W2166910080 cites W2065359210 @default.
- W2166910080 cites W2068678316 @default.
- W2166910080 cites W2079203989 @default.
- W2166910080 cites W2082590458 @default.
- W2166910080 cites W2084955584 @default.
- W2166910080 cites W2086114940 @default.
- W2166910080 cites W2088376011 @default.
- W2166910080 cites W2092892551 @default.
- W2166910080 cites W2097000949 @default.
- W2166910080 cites W2105343086 @default.
- W2166910080 cites W2110427132 @default.
- W2166910080 cites W2112990976 @default.
- W2166910080 cites W2128915181 @default.
- W2166910080 cites W2131577940 @default.
- W2166910080 cites W2132527998 @default.
- W2166910080 cites W2133174477 @default.
- W2166910080 cites W2133899724 @default.
- W2166910080 cites W2143182775 @default.
- W2166910080 cites W2143481531 @default.
- W2166910080 cites W2149138696 @default.
- W2166910080 cites W2152616688 @default.
- W2166910080 cites W2167525400 @default.
- W2166910080 cites W2171569953 @default.
- W2166910080 cites W2949977409 @default.
- W2166910080 hasPublicationYear "2015" @default.
- W2166910080 type Work @default.
- W2166910080 sameAs 2166910080 @default.
- W2166910080 citedByCount "1" @default.
- W2166910080 crossrefType "journal-article" @default.
- W2166910080 hasAuthorship W2166910080A5001083315 @default.
- W2166910080 hasAuthorship W2166910080A5040553801 @default.
- W2166910080 hasAuthorship W2166910080A5046688401 @default.
- W2166910080 hasAuthorship W2166910080A5060966201 @default.
- W2166910080 hasAuthorship W2166910080A5069858660 @default.
- W2166910080 hasConcept C104317684 @default.
- W2166910080 hasConcept C118552586 @default.
- W2166910080 hasConcept C123273963 @default.
- W2166910080 hasConcept C126838900 @default.
- W2166910080 hasConcept C143409427 @default.
- W2166910080 hasConcept C15744967 @default.
- W2166910080 hasConcept C169760540 @default.
- W2166910080 hasConcept C2776984250 @default.
- W2166910080 hasConcept C2781192897 @default.
- W2166910080 hasConcept C2984223407 @default.
- W2166910080 hasConcept C30481170 @default.
- W2166910080 hasConcept C54355233 @default.
- W2166910080 hasConcept C65835030 @default.
- W2166910080 hasConcept C71924100 @default.
- W2166910080 hasConcept C86803240 @default.
- W2166910080 hasConceptScore W2166910080C104317684 @default.
- W2166910080 hasConceptScore W2166910080C118552586 @default.
- W2166910080 hasConceptScore W2166910080C123273963 @default.
- W2166910080 hasConceptScore W2166910080C126838900 @default.
- W2166910080 hasConceptScore W2166910080C143409427 @default.
- W2166910080 hasConceptScore W2166910080C15744967 @default.
- W2166910080 hasConceptScore W2166910080C169760540 @default.
- W2166910080 hasConceptScore W2166910080C2776984250 @default.
- W2166910080 hasConceptScore W2166910080C2781192897 @default.
- W2166910080 hasConceptScore W2166910080C2984223407 @default.
- W2166910080 hasConceptScore W2166910080C30481170 @default.
- W2166910080 hasConceptScore W2166910080C54355233 @default.
- W2166910080 hasConceptScore W2166910080C65835030 @default.
- W2166910080 hasConceptScore W2166910080C71924100 @default.
- W2166910080 hasConceptScore W2166910080C86803240 @default.
- W2166910080 hasLocation W21669100801 @default.
- W2166910080 hasOpenAccess W2166910080 @default.
- W2166910080 hasPrimaryLocation W21669100801 @default.