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- W2166925346 abstract "The stable conformations of GABA(A)-benzodiazepine receptor bivalent ligands 2 and 3 were determined by low temperature NMR spectroscopy and confirmed by single crystal X-ray analysis. The linear conformation was important for these dimers to access the binding site and exhibit potent in vitro affinity as illustrated for alpha5 subtype selective ligand 2 (15 nM). Bivalent ligand 3 with the 5 atom linker folded back upon itself both in solution and in the solid state, moreover, it did not bind to Bz receptors." @default.
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- W2166925346 date "2004-03-01" @default.
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- W2166925346 title "Determination of the stable conformation of GABAA-benzodiazepine receptor bivalent ligands by low temperature NMR and X-ray analysis" @default.
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- W2166925346 doi "https://doi.org/10.1016/j.bmcl.2004.01.018" @default.
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