FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166945900> ?p ?o ?g. }

• W2166945900 endingPage "2331" @default.
• W2166945900 startingPage "2321" @default.
• W2166945900 abstract "Experimental infection of rats with human adenovirus type 36 (Ad-36) promotes adipogenesis and improves insulin sensitivity in a manner reminiscent of the pharmacologic effect of thiozolinediones. To exploit the potential of the viral proteins as a therapeutic target for treating insulin resistance, this study investigated the ability of Ad-36 to induce metabolically favorable changes in human adipose tissue.We determined whether Ad-36 increases glucose uptake in human adipose tissue explants. Cell-signaling pathways targeted by Ad-36 to increase glucose uptake were determined in the explants and human adipose-derived stem cells. Ad-2, a nonadipogenic human adenovirus, was used as a negative control. As a proof of concept, nondiabetic and diabetic subjects were screened for the presence of Ad-36 antibodies to ascertain if natural Ad-36 infection predicted improved glycemic control.Ad-36 increased glucose uptake by adipose tissue explants obtained from nondiabetic and diabetic subjects. Without insulin stimulation, Ad-36 upregulated expressions of several proadipogenic genes, adiponectin, and fatty acid synthase and reduced the expression of inflammatory cytokine macrophage chemoattractant protein-1 in a phosphotidylinositol 3-kinase (PI3K)-dependent manner. In turn, the activation of PI3K by Ad-36 was independent of insulin receptor signaling but dependent on Ras signaling recruited by Ad-36. Ad-2 was nonadipogenic and did not increase glucose uptake. Natural Ad-36 infection in nondiabetic and diabetic subjects was associated with significantly lower fasting glucose levels and A1C, respectively.Ad-36 proteins may provide novel therapeutic targets that remodel human adipose tissue to a more metabolically favorable profile." @default.
• W2166945900 created "2016-06-24" @default.
• W2166945900 creator A5004947412 @default.
• W2166945900 creator A5014383282 @default.
• W2166945900 creator A5015552841 @default.
• W2166945900 creator A5023144389 @default.
• W2166945900 creator A5028755841 @default.
• W2166945900 creator A5035270435 @default.
• W2166945900 creator A5061499605 @default.
• W2166945900 creator A5068543009 @default.
• W2166945900 creator A5072825980 @default.
• W2166945900 creator A5077475196 @default.
• W2166945900 creator A5080960032 @default.
• W2166945900 date "2008-09-01" @default.
• W2166945900 modified "2023-10-17" @default.
• W2166945900 title "Metabolically Favorable Remodeling of Human Adipose Tissue by Human Adenovirus Type 36" @default.
• W2166945900 cites W1530493122 @default.
• W2166945900 cites W1540022826 @default.
• W2166945900 cites W1751222734 @default.
• W2166945900 cites W1877406376 @default.
• W2166945900 cites W1884105702 @default.
• W2166945900 cites W1924240621 @default.
• W2166945900 cites W1965400751 @default.
• W2166945900 cites W1975561886 @default.
• W2166945900 cites W1976151688 @default.
• W2166945900 cites W1976974669 @default.
• W2166945900 cites W1979031127 @default.
• W2166945900 cites W1980580084 @default.
• W2166945900 cites W1984706102 @default.
• W2166945900 cites W1986178341 @default.
• W2166945900 cites W1989817267 @default.
• W2166945900 cites W1994298923 @default.
• W2166945900 cites W1994643655 @default.
• W2166945900 cites W1997304834 @default.
• W2166945900 cites W2000365319 @default.
• W2166945900 cites W2003978407 @default.
• W2166945900 cites W2006361131 @default.
• W2166945900 cites W2010349266 @default.
• W2166945900 cites W2012349288 @default.
• W2166945900 cites W2012383221 @default.
• W2166945900 cites W2013219143 @default.
• W2166945900 cites W2016080258 @default.
• W2166945900 cites W2020331673 @default.
• W2166945900 cites W2023128145 @default.
• W2166945900 cites W2025688934 @default.
• W2166945900 cites W2030445381 @default.
• W2166945900 cites W2034851420 @default.
• W2166945900 cites W2044977694 @default.
• W2166945900 cites W2046728427 @default.
• W2166945900 cites W2051767855 @default.
• W2166945900 cites W2053881520 @default.
• W2166945900 cites W2060443170 @default.
• W2166945900 cites W2061957280 @default.
• W2166945900 cites W2062756228 @default.
• W2166945900 cites W2065077464 @default.
• W2166945900 cites W2065276626 @default.
• W2166945900 cites W2067951272 @default.
• W2166945900 cites W2069245874 @default.
• W2166945900 cites W2076654649 @default.
• W2166945900 cites W2079832429 @default.
• W2166945900 cites W2081724143 @default.
• W2166945900 cites W2084942885 @default.
• W2166945900 cites W2088099561 @default.
• W2166945900 cites W2097794068 @default.
• W2166945900 cites W2101691933 @default.
• W2166945900 cites W2104302533 @default.
• W2166945900 cites W2113139299 @default.
• W2166945900 cites W2124241212 @default.
• W2166945900 cites W2128920100 @default.
• W2166945900 cites W2129867029 @default.
• W2166945900 cites W2148014629 @default.
• W2166945900 cites W2148920753 @default.
• W2166945900 cites W2150658610 @default.
• W2166945900 cites W2153266804 @default.
• W2166945900 cites W2154132292 @default.
• W2166945900 cites W2157868136 @default.
• W2166945900 cites W2159346623 @default.
• W2166945900 cites W2165366558 @default.
• W2166945900 cites W2167942872 @default.
• W2166945900 cites W2318847305 @default.
• W2166945900 cites W2462473561 @default.
• W2166945900 cites W2467128314 @default.
• W2166945900 cites W2473495692 @default.
• W2166945900 cites W262915389 @default.
• W2166945900 cites W4256397386 @default.
• W2166945900 doi "https://doi.org/10.2337/db07-1311" @default.
• W2166945900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2518483" @default.
• W2166945900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18599527" @default.
• W2166945900 hasPublicationYear "2008" @default.
• W2166945900 type Work @default.
• W2166945900 sameAs 2166945900 @default.
• W2166945900 citedByCount "73" @default.
• W2166945900 countsByYear W21669459002012 @default.
• W2166945900 countsByYear W21669459002013 @default.
• W2166945900 countsByYear W21669459002014 @default.
• W2166945900 countsByYear W21669459002015 @default.
• W2166945900 countsByYear W21669459002016 @default.
• W2166945900 countsByYear W21669459002017 @default.

• next