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• W2166955092 abstract "Two distinct families of small molecules were discovered as novel α7 nicotinic acetylcholine receptor (nAChR) antagonists by pharmacophore-based virtual screening. These novel antagonists exhibited selectivity for the neuronal α7 subtype over other nAChRs and good brain penetration. Neuroprotection was demonstrated by representative compounds 7i and 8 in a mouse seizure-like behavior model induced by the nerve agent diisopropylfluorophosphate (DFP). These novel nAChR antagonists have potential use as antidote for organophosphorus nerve agent intoxication." @default.
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• W2166955092 date "2010-08-01" @default.
• W2166955092 modified "2023-09-27" @default.
• W2166955092 title "Discovery of novel α7 nicotinic receptor antagonists" @default.
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• W2166955092 doi "https://doi.org/10.1016/j.bmcl.2010.06.103" @default.
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