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- W2166977984 abstract "Lymphomatoid papulosis (LyP) is rarely seen in children. We report a case of LyP in a 4-year-old boy in whom immunopathologic studies demonstrated T cell antigen deletions. In contrast to all but two previous reports, a T suppressor (CD-8) phenotype was predominant. Southern blot analysis of DNA isolated from a typical skin lesion indicated a clonal rearrangement of the T cell receptor beta gene. Because of a 10% frequency of malignant lymphomas in patients with LyP, long-term observation is crucial, especially in children. We recommend routine clonal rearrangement studies for aid in diagnosis and follow-up, and as possible prognostic indicators in children with this condition." @default.
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- W2166977984 date "1990-03-01" @default.
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- W2166977984 title "Lymphomatoid Papulosis with Antigen Deletion and Clonal Rearrangement in a 4-Year-Old Boy" @default.
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- W2166977984 doi "https://doi.org/10.1111/j.1525-1470.1990.tb01072.x" @default.
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