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- W2166985142 abstract "The ability of living cells to maintain an inheritable memory of their gene-expression state is key to cellular differentiation. Bacterial lysogeny serves as a simple paradigm for long-term cellular memory. In this study, we address the following question: in the absence of external perturbation, how long will a cell stay in the lysogenic state before spontaneously switching away from that state? We show by direct measurement that lysogen stability exhibits a simple exponential dependence on the frequency of activity bursts from the fate-determining gene, cI. We quantify these gene-activity bursts using single-molecule-resolution mRNA measurements in individual cells, analyzed using a stochastic mathematical model of the gene-network kinetics. The quantitative relation between stability and gene activity is independent of the fine details of gene regulation, suggesting that a quantitative prediction of cell-state stability may also be possible in more complex systems." @default.
- W2166985142 created "2016-06-24" @default.
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- W2166985142 date "2010-01-01" @default.
- W2166985142 modified "2023-10-15" @default.
- W2166985142 title "Lysogen stability is determined by the frequency of activity bursts from the fate‐determining gene" @default.
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- W2166985142 doi "https://doi.org/10.1038/msb.2010.96" @default.
- W2166985142 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3010116" @default.
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