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• W2166988421 startingPage "349" @default.
• W2166988421 abstract "Down syndrome (trisomy 21) neurons display an increased rate of apoptosis in vitro. The genes on chromosome 21 that mediate this increased cell death remain to be elucidated. Here we show that the chromosome 21 transcription factor Ets2, a gene that is overexpressed in Down syndrome, is expressed in neurons, and that moderate overexpression of Ets2 leads to increased apoptosis of primary neuronal cultures from Ets2 tg mice that involves activation of caspase-3. Our data therefore suggest that overexpression of ETS2 may contribute to the increased rate of apoptosis of neurons in Down syndrome." @default.
• W2166988421 created "2016-06-24" @default.
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• W2166988421 date "2003-12-01" @default.
• W2166988421 modified "2023-10-01" @default.
• W2166988421 title "Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis" @default.
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• W2166988421 doi "https://doi.org/10.1016/s0969-9961(03)00107-4" @default.
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