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• W2167029148 abstract "Steroid hormone receptors initiate a genetic program tightly regulated by the chromatin environment of the responsive regions. Using the glucocorticoid receptor (GR) as a model factor for transcriptional initiation, we classified chromatin structure through formaldehyde-assisted isolation of regulatory elements (FAIRE). We looked at dynamic changes in FAIRE signals during GR activation specifically at regions of receptor interaction. We found a distribution of GR-responsive regions with diverse responses to activation and chromatin modulation. The majority of GR binding regions demonstrate increases in FAIRE signal in response to ligand. However, the majority GR-responsive regions shared a similar FAIRE signal in the basal chromatin state, suggesting a common chromatin structure for GR recruitment. Supporting this notion, global FAIRE sequencing (seq) data indicated an enrichment of signal surrounding the GR binding site prior to activation. Brg-1 knockdown showed response element-specific effects of ATPase-dependent chromatin remodeling. FAIRE induction was universally decreased by Brg-1 depletion, but to varying degrees in a target specific manner. Taken together, these data suggest classes of nuclear receptor response regions that react to activation through different chromatin regulatory events and identify a chromatin structure that classifies the majority of response elements tested." @default.
• W2167029148 created "2016-06-24" @default.
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• W2167029148 date "2012-05-01" @default.
• W2167029148 modified "2023-10-15" @default.
• W2167029148 title "Analysis of Chromatin Dynamics during Glucocorticoid Receptor Activation" @default.
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• W2167029148 doi "https://doi.org/10.1128/mcb.06206-11" @default.
• W2167029148 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3347412" @default.
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