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- W2167029308 abstract "Several gene mutations have been shown to have clinical implications in patients with acute myeloid leukemia (AML). However, the prognostic impact of gene mutations in AML patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains unclear. We retrospectively evaluated the clinical implication of 10 gene mutations in 325 adult AML patients; 100 of them received allo-HSCT and 225 did not. The genetic alterations analyzed included NPM1, FLT3-ITD, FLT3-TKD, CEBPA, N-RAS, K-RAS, MLL-PTD, IDH1, AML1/RUNX1, and WT1. In patients who did not receive allo-HSCT, older age, higher WBC count, unfavorable karyotype, FLT3-ITD, and AML1/RUNX1 mutation were significantly associated with poor overall survival, while CEBPA mutation and NPM1mut/FLT3-ITDneg were associated with good outcome in both univariate and multivariate analyses. However, in allo-HSCT patients, preHSCT disease status, karyotype, use of HLA-identical sibling donor, CEBPA double mutation, and AML1/RUNX1 mutation were five independent factors that affect post-HSCT overall survival (OS) and relapse-free survival (RFS). The prognostic impacts of FLT3-ITD and NPM1mut/FLT3-ITDneg were lost in AML patients receiving allo-HSCT. Interestingly, AML1/RUNX1 mutation had a trend to be associated with good, rather than poor, prognosis in this group of patients (p = 0.073). The few patients with K-RAS or WT1 mutation also had poor OS and RFS after HSCT. In conclusion, different types of gene mutations might have unique prognostic impact on allo-HSCT outcome in AML patients. These results need to be confirmed by further studies in more patients." @default.
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- W2167029308 date "2011-02-01" @default.
- W2167029308 modified "2023-10-17" @default.
- W2167029308 title "Prognostic Implication of Gene Mutations in Adult Acute Myeloid Leukemia Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation" @default.
- W2167029308 doi "https://doi.org/10.1016/j.bbmt.2010.12.077" @default.
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