FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167032249> ?p ?o ?g. }

• W2167032249 endingPage "1426" @default.
• W2167032249 startingPage "1422" @default.
• W2167032249 abstract "Mapping by admixture linkage disequilibrium (LD) detected strong association between nonmuscle myosin heavy chain 9 gene (<i>MYH9</i>) variants on chromosome 22 and nondiabetic nephropathy in African Americans. <i>MYH9</i>-related variants were posited to be the probable, but not necessarily the definitive, causal variants as a result of impressive statistical evidence of association, renal expression, and a role in autosomal dominant <i>MYH9</i> disorders characterized by progressive glomerulosclerosis (Epstein and Fechtner syndromes). Dense mapping within <i>MYH9</i> revealed striking LD patterns and racial variation in risk allele frequencies, suggesting population genetic factors such as selection may be operative in this region. Genovese and colleagues examined large chromosomal regions adjacent to <i>MYH9</i> using genome-wide association methods and non-HapMap single nucleotide polymorphisms identified in Yoruba from the 1000 Genomes project. Statistically stronger associations were detected between two independent sequence variants in the Apolipoprotein L1 gene (<i>APOL1</i>) and nondiabetic nephropathy in African Americans, with odds ratios of 10.5 in idiopathic FSGS and 7.3 in hypertension-attributed ESRD. These kidney disease risk variants likely rose to high frequency in Africa because they confer resistance to trypanosomal infection and protect from African sleeping sickness. Risk variants in <i>MYH9</i> and <i>APOL1</i> are in strong LD, and the genetic risk that was previously attributed to <i>MYH9</i> may reside, in part or in whole, in <i>APOL1</i>, although more complex models of risk cannot be excluded. This association likely explains racial disparities in nondiabetic nephropathy as a result of the high prevalence of risk alleles in individuals of African ancestry." @default.
• W2167032249 created "2016-06-24" @default.
• W2167032249 creator A5008886933 @default.
• W2167032249 creator A5020267280 @default.
• W2167032249 creator A5024733766 @default.
• W2167032249 creator A5030650722 @default.
• W2167032249 creator A5044494633 @default.
• W2167032249 creator A5047201622 @default.
• W2167032249 creator A5053865342 @default.
• W2167032249 creator A5059764563 @default.
• W2167032249 creator A5087036525 @default.
• W2167032249 date "2010-09-01" @default.
• W2167032249 modified "2023-10-07" @default.
• W2167032249 title "The Apolipoprotein L1 (APOL1) Gene and Nondiabetic Nephropathy in African Americans" @default.
• W2167032249 cites W1998399313 @default.
• W2167032249 cites W2001115778 @default.
• W2167032249 cites W2013731835 @default.
• W2167032249 cites W2025026896 @default.
• W2167032249 cites W2042717820 @default.
• W2167032249 cites W2058286579 @default.
• W2167032249 cites W2100586653 @default.
• W2167032249 cites W2102315160 @default.
• W2167032249 cites W2104731110 @default.
• W2167032249 cites W2110597957 @default.
• W2167032249 cites W2117207378 @default.
• W2167032249 cites W2121965895 @default.
• W2167032249 cites W2160180886 @default.
• W2167032249 cites W2166965520 @default.
• W2167032249 cites W2413578523 @default.
• W2167032249 doi "https://doi.org/10.1681/asn.2010070730" @default.
• W2167032249 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7391383" @default.
• W2167032249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20688934" @default.
• W2167032249 hasPublicationYear "2010" @default.
• W2167032249 type Work @default.
• W2167032249 sameAs 2167032249 @default.
• W2167032249 citedByCount "236" @default.
• W2167032249 countsByYear W21670322492012 @default.
• W2167032249 countsByYear W21670322492013 @default.
• W2167032249 countsByYear W21670322492014 @default.
• W2167032249 countsByYear W21670322492015 @default.
• W2167032249 countsByYear W21670322492016 @default.
• W2167032249 countsByYear W21670322492017 @default.
• W2167032249 countsByYear W21670322492018 @default.
• W2167032249 countsByYear W21670322492019 @default.
• W2167032249 countsByYear W21670322492020 @default.
• W2167032249 countsByYear W21670322492021 @default.
• W2167032249 countsByYear W21670322492022 @default.
• W2167032249 countsByYear W21670322492023 @default.
• W2167032249 crossrefType "journal-article" @default.
• W2167032249 hasAuthorship W2167032249A5008886933 @default.
• W2167032249 hasAuthorship W2167032249A5020267280 @default.
• W2167032249 hasAuthorship W2167032249A5024733766 @default.
• W2167032249 hasAuthorship W2167032249A5030650722 @default.
• W2167032249 hasAuthorship W2167032249A5044494633 @default.
• W2167032249 hasAuthorship W2167032249A5047201622 @default.
• W2167032249 hasAuthorship W2167032249A5053865342 @default.
• W2167032249 hasAuthorship W2167032249A5059764563 @default.
• W2167032249 hasAuthorship W2167032249A5087036525 @default.
• W2167032249 hasBestOaLocation W21670322491 @default.
• W2167032249 hasConcept C104317684 @default.
• W2167032249 hasConcept C134018914 @default.
• W2167032249 hasConcept C135763542 @default.
• W2167032249 hasConcept C153209595 @default.
• W2167032249 hasConcept C177580304 @default.
• W2167032249 hasConcept C180754005 @default.
• W2167032249 hasConcept C186413461 @default.
• W2167032249 hasConcept C197754878 @default.
• W2167032249 hasConcept C2781184683 @default.
• W2167032249 hasConcept C2908647359 @default.
• W2167032249 hasConcept C35605836 @default.
• W2167032249 hasConcept C54355233 @default.
• W2167032249 hasConcept C555293320 @default.
• W2167032249 hasConcept C71924100 @default.
• W2167032249 hasConcept C86803240 @default.
• W2167032249 hasConcept C99454951 @default.
• W2167032249 hasConceptScore W2167032249C104317684 @default.
• W2167032249 hasConceptScore W2167032249C134018914 @default.
• W2167032249 hasConceptScore W2167032249C135763542 @default.
• W2167032249 hasConceptScore W2167032249C153209595 @default.
• W2167032249 hasConceptScore W2167032249C177580304 @default.
• W2167032249 hasConceptScore W2167032249C180754005 @default.
• W2167032249 hasConceptScore W2167032249C186413461 @default.
• W2167032249 hasConceptScore W2167032249C197754878 @default.
• W2167032249 hasConceptScore W2167032249C2781184683 @default.
• W2167032249 hasConceptScore W2167032249C2908647359 @default.
• W2167032249 hasConceptScore W2167032249C35605836 @default.
• W2167032249 hasConceptScore W2167032249C54355233 @default.
• W2167032249 hasConceptScore W2167032249C555293320 @default.
• W2167032249 hasConceptScore W2167032249C71924100 @default.
• W2167032249 hasConceptScore W2167032249C86803240 @default.
• W2167032249 hasConceptScore W2167032249C99454951 @default.
• W2167032249 hasIssue "9" @default.
• W2167032249 hasLocation W21670322491 @default.
• W2167032249 hasLocation W21670322492 @default.
• W2167032249 hasLocation W21670322493 @default.
• W2167032249 hasOpenAccess W2167032249 @default.
• W2167032249 hasPrimaryLocation W21670322491 @default.
• W2167032249 hasRelatedWork W1492100763 @default.

• next