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- W2167052275 abstract "The combined deficiency of β-galactosidase and neuraminidase in human fibroblasts can be corrected to nearly normal values. This can be accomplished by addition of concentrated culture medium obtained after NH4Cl stimulation of different types of human fibroblasts, including those with an isolated β-galactosidase or neuraminidase deficiency. The corrective factor is a macromolecular glycoprotein, which is labile at 60°C. Its uptake by human fibroblasts is competitively inhibited by mannose-6-phosphate and its corrective action within β-gal−/neur− fibroblasts continues during a “chase” of 72 hours." @default.
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- W2167052275 date "1981-11-01" @default.
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- W2167052275 title "Correction of combined β-galactosidase/neuraminidase deficiency in human fibroblasts" @default.
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- W2167052275 doi "https://doi.org/10.1016/0006-291x(81)91692-2" @default.
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