FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167069812> ?p ?o ?g. }

• W2167069812 endingPage "220" @default.
• W2167069812 startingPage "213" @default.
• W2167069812 abstract "This study aimed at identifying the type and functional significance of potassium channels and voltage-dependent calcium channels (Ca v ) in single rat JG cells using whole-cell patch clamp. Single JG cells displayed outward rectification at positive membrane potentials and limited net currents between −60 and −10 mV. Blockade of K + channels with TEA inhibited 83% of the current at +105 mV. Inhibition of K V channels with 4-AP inhibited 21% of the current. Blockade of calcium-sensitive voltage-gated K + channels (BK Ca ) with charybdotoxin or iberiotoxin inhibited 89% and 82% of the current, respectively. Double immunofluorescence confirmed the presence of BK Ca and renin in the same cell. cAMP increased the outward current by 1.6-fold, and this was inhibited by 74% with iberiotoxin. Expression of the cAMP-sensitive splice variant (ZERO) of BK Ca was confirmed in single-sampled JG cells by RT-PCR. The resting membrane potential of JG cells was −32 mV and activation of BK Ca with cAMP hyperpolarized cells on average 16 mV, and inhibition with TEA depolarized cells by 17 mV. The cells displayed typical high-voltage activated calcium currents sensitive to the L-type Ca v blocker calciseptine. RT-PCR analysis and double-immunofluorescence labeling showed coexpression of renin and L-type Ca v 1.2. The cAMP-mediated increase in exocytosis (measured as membrane capacitance) was inhibited by depolarization to +10 mV, and this inhibitory effect was blocked with calciseptine, whereas K + -blockers had no effect. We conclude that JG cells express functional cAMP-sensitive BK Ca channels (the ZERO splice variant) and voltage-dependent L-type Ca 2+ channels." @default.
• W2167069812 created "2016-06-24" @default.
• W2167069812 creator A5003232489 @default.
• W2167069812 creator A5003572766 @default.
• W2167069812 creator A5039219230 @default.
• W2167069812 creator A5045719505 @default.
• W2167069812 creator A5062936478 @default.
• W2167069812 date "2003-08-08" @default.
• W2167069812 modified "2023-10-16" @default.
• W2167069812 title "Molecular and Functional Identification of Cyclic AMP-Sensitive BK _Ca Potassium Channels (ZERO Variant) and L-Type Voltage-Dependent Calcium Channels in Single Rat Juxtaglomerular Cells" @default.
• W2167069812 cites W1936823206 @default.
• W2167069812 cites W1964359392 @default.
• W2167069812 cites W1966763660 @default.
• W2167069812 cites W1993110730 @default.
• W2167069812 cites W2004288562 @default.
• W2167069812 cites W2006594206 @default.
• W2167069812 cites W2013801867 @default.
• W2167069812 cites W2023136543 @default.
• W2167069812 cites W2045299203 @default.
• W2167069812 cites W2059196423 @default.
• W2167069812 cites W2078768108 @default.
• W2167069812 cites W2089157424 @default.
• W2167069812 cites W2091770316 @default.
• W2167069812 cites W2093619119 @default.
• W2167069812 cites W2107745544 @default.
• W2167069812 cites W2108714987 @default.
• W2167069812 cites W2140236160 @default.
• W2167069812 cites W2171150152 @default.
• W2167069812 cites W2314825743 @default.
• W2167069812 cites W7247982 @default.
• W2167069812 doi "https://doi.org/10.1161/01.res.0000085041.70276.3d" @default.
• W2167069812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12842920" @default.
• W2167069812 hasPublicationYear "2003" @default.
• W2167069812 type Work @default.
• W2167069812 sameAs 2167069812 @default.
• W2167069812 citedByCount "35" @default.
• W2167069812 countsByYear W21670698122012 @default.
• W2167069812 countsByYear W21670698122013 @default.
• W2167069812 countsByYear W21670698122017 @default.
• W2167069812 countsByYear W21670698122018 @default.
• W2167069812 countsByYear W21670698122021 @default.
• W2167069812 crossrefType "journal-article" @default.
• W2167069812 hasAuthorship W2167069812A5003232489 @default.
• W2167069812 hasAuthorship W2167069812A5003572766 @default.
• W2167069812 hasAuthorship W2167069812A5039219230 @default.
• W2167069812 hasAuthorship W2167069812A5045719505 @default.
• W2167069812 hasAuthorship W2167069812A5062936478 @default.
• W2167069812 hasConcept C12554922 @default.
• W2167069812 hasConcept C147944092 @default.
• W2167069812 hasConcept C153911025 @default.
• W2167069812 hasConcept C170493617 @default.
• W2167069812 hasConcept C178790620 @default.
• W2167069812 hasConcept C181911157 @default.
• W2167069812 hasConcept C185592680 @default.
• W2167069812 hasConcept C18699975 @default.
• W2167069812 hasConcept C2779411790 @default.
• W2167069812 hasConcept C2780419564 @default.
• W2167069812 hasConcept C4141045 @default.
• W2167069812 hasConcept C519063684 @default.
• W2167069812 hasConcept C55493867 @default.
• W2167069812 hasConcept C61144316 @default.
• W2167069812 hasConcept C83743174 @default.
• W2167069812 hasConcept C86803240 @default.
• W2167069812 hasConceptScore W2167069812C12554922 @default.
• W2167069812 hasConceptScore W2167069812C147944092 @default.
• W2167069812 hasConceptScore W2167069812C153911025 @default.
• W2167069812 hasConceptScore W2167069812C170493617 @default.
• W2167069812 hasConceptScore W2167069812C178790620 @default.
• W2167069812 hasConceptScore W2167069812C181911157 @default.
• W2167069812 hasConceptScore W2167069812C185592680 @default.
• W2167069812 hasConceptScore W2167069812C18699975 @default.
• W2167069812 hasConceptScore W2167069812C2779411790 @default.
• W2167069812 hasConceptScore W2167069812C2780419564 @default.
• W2167069812 hasConceptScore W2167069812C4141045 @default.
• W2167069812 hasConceptScore W2167069812C519063684 @default.
• W2167069812 hasConceptScore W2167069812C55493867 @default.
• W2167069812 hasConceptScore W2167069812C61144316 @default.
• W2167069812 hasConceptScore W2167069812C83743174 @default.
• W2167069812 hasConceptScore W2167069812C86803240 @default.
• W2167069812 hasIssue "3" @default.
• W2167069812 hasLocation W21670698121 @default.
• W2167069812 hasLocation W21670698122 @default.
• W2167069812 hasOpenAccess W2167069812 @default.
• W2167069812 hasPrimaryLocation W21670698121 @default.
• W2167069812 hasRelatedWork W1968775375 @default.
• W2167069812 hasRelatedWork W2001908368 @default.
• W2167069812 hasRelatedWork W2015189408 @default.
• W2167069812 hasRelatedWork W2016451272 @default.
• W2167069812 hasRelatedWork W2037784517 @default.
• W2167069812 hasRelatedWork W2048385760 @default.
• W2167069812 hasRelatedWork W2084903350 @default.
• W2167069812 hasRelatedWork W2088281397 @default.
• W2167069812 hasRelatedWork W2090405680 @default.
• W2167069812 hasRelatedWork W2405958842 @default.
• W2167069812 hasVolume "93" @default.
• W2167069812 isParatext "false" @default.
• W2167069812 isRetracted "false" @default.
• W2167069812 magId "2167069812" @default.

• next