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• W2167070987 abstract "Dendritic morphology is the structural correlate for receiving and processing inputs to a neuron. An interesting question then is what the design principles and the functional consequences of enlarged or shrinked dendritic trees might be. As yet, only a few studies have examined the effects of neuron size changes. Two theoretical scaling modes have been analyzed, conservative (isoelectrotonic) scaling (preserves the passive and active response properties) and isometric scaling (steps up low pass-filtering of inputs). It has been suggested that both scaling modes were verified in neuroanatomical studies. To overcome obvious limitations of these studies like small size of analyzed samples and restricted validity of utilized scaling measures, we considered the scaling problem of neurons on the basis of large sample data and by employing a more general method of scaling analysis. This method consists in computing the morphoelectrotonic transform (MET) of neurons. The MET maps the neuron from anatomical space into electrotonic space using the logarithm of voltage attenuation as the distance metric. The theory underlying this approach is described and then applied to two samples of morphologically reconstructed pyramidal neurons (cells from neocortex of wildtype and synRas transgenic mice) using the NEURON simulator. In a previous study, we could verify a striking increase of dendritic tree size in synRas pyramidal neurons. Surprisingly, in this study the statistical analysis of the sample MET dendrograms revealed that the electrotonic architecture of these neurons scaled roughly in a MET-conserving mode. In conclusion, our results suggest only a minor impact of the Ras protein on dendritic electroanatomy, with non-significant changes of most regions of the corresponding METs." @default.
• W2167070987 created "2016-06-24" @default.
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• W2167070987 creator A5024787507 @default.
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• W2167070987 date "2007-06-01" @default.
• W2167070987 modified "2023-10-09" @default.
• W2167070987 title "Scaling properties of pyramidal neurons in mice neocortex" @default.
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• W2167070987 doi "https://doi.org/10.1016/j.mbs.2006.08.019" @default.
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