FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167102790> ?p ?o ?g. }

• W2167102790 endingPage "L505" @default.
• W2167102790 startingPage "L498" @default.
• W2167102790 abstract "In the fetus, leptin in the circulation increases at late gestation and likely influences fetal organ development. Increased surfactant by leptin was previously demonstrated in vitro using fetal lung explant. We hypothesized that leptin treatment given to fetal sheep and pregnant mice might increase surfactant synthesis in the fetal lung in vivo. At 122–124 days gestational age (term: 150 days), fetal sheep were injected with 5 mg of leptin or vehicle using ultrasound guidance. Three and a half days after injection, preterm lambs were delivered, and lung function was studied during 30-min ventilation, followed by pulmonary surfactant components analyses. Pregnant A/J mice were given 30 or 300 mg of leptin or vehicle by intraperitoneal injection according to five study protocols with different doses, number of treatments, and gestational ages to treat. Surfactant components were analyzed in fetal lung 24 h after the last maternal treatment. Leptin injection given to fetal sheep increased fetal body weight. Control and leptin-treated groups were similar in lung function (preterm newborn lamb), surfactant components pool sizes (lamb and fetal mice), and expression of genes related to surfactant synthesis in the lung (fetal mice). Likewise, saturated phosphatidylcholine and phospholipid were normal in mice lungs with absence of circulating leptin (ob/ob mice) at all ages. These studies coincided in findings that neither exogenously given leptin nor deficiency of leptin influenced fetal lung maturation or surfactant pool sizes in vivo. Furthermore, the key genes critically required for surfactant synthesis were not affected by leptin treatment." @default.
• W2167102790 created "2016-06-24" @default.
• W2167102790 creator A5037198457 @default.
• W2167102790 creator A5037714226 @default.
• W2167102790 creator A5076459383 @default.
• W2167102790 date "2011-03-01" @default.
• W2167102790 modified "2023-10-17" @default.
• W2167102790 title "Leptin does not influence surfactant synthesis in fetal sheep and mice lungs" @default.
• W2167102790 cites W101877409 @default.
• W2167102790 cites W1497019223 @default.
• W2167102790 cites W1775749144 @default.
• W2167102790 cites W1840067061 @default.
• W2167102790 cites W1907072707 @default.
• W2167102790 cites W1967968986 @default.
• W2167102790 cites W1974830013 @default.
• W2167102790 cites W1981787273 @default.
• W2167102790 cites W1982625683 @default.
• W2167102790 cites W1996583060 @default.
• W2167102790 cites W1996682753 @default.
• W2167102790 cites W1996713062 @default.
• W2167102790 cites W2013583119 @default.
• W2167102790 cites W2014093920 @default.
• W2167102790 cites W2022819088 @default.
• W2167102790 cites W2031823675 @default.
• W2167102790 cites W2036571752 @default.
• W2167102790 cites W2036754828 @default.
• W2167102790 cites W2041691732 @default.
• W2167102790 cites W2046929962 @default.
• W2167102790 cites W2053815511 @default.
• W2167102790 cites W2055956383 @default.
• W2167102790 cites W2060682066 @default.
• W2167102790 cites W2061132963 @default.
• W2167102790 cites W2062896408 @default.
• W2167102790 cites W2078506029 @default.
• W2167102790 cites W2082454963 @default.
• W2167102790 cites W2090285743 @default.
• W2167102790 cites W2093150863 @default.
• W2167102790 cites W2105208033 @default.
• W2167102790 cites W2109176791 @default.
• W2167102790 cites W2109945170 @default.
• W2167102790 cites W2115112355 @default.
• W2167102790 cites W2116030945 @default.
• W2167102790 cites W2118499682 @default.
• W2167102790 cites W2131626429 @default.
• W2167102790 cites W2136100905 @default.
• W2167102790 cites W2136992413 @default.
• W2167102790 cites W2140925859 @default.
• W2167102790 cites W2147137526 @default.
• W2167102790 cites W2149156499 @default.
• W2167102790 cites W2153455997 @default.
• W2167102790 cites W2158181526 @default.
• W2167102790 cites W2161653893 @default.
• W2167102790 cites W2161944247 @default.
• W2167102790 cites W2168182154 @default.
• W2167102790 cites W2168919872 @default.
• W2167102790 cites W2169890072 @default.
• W2167102790 cites W2331767419 @default.
• W2167102790 cites W4231240600 @default.
• W2167102790 doi "https://doi.org/10.1152/ajplung.00418.2010" @default.
• W2167102790 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3064284" @default.
• W2167102790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21216976" @default.
• W2167102790 hasPublicationYear "2011" @default.
• W2167102790 type Work @default.
• W2167102790 sameAs 2167102790 @default.
• W2167102790 citedByCount "15" @default.
• W2167102790 countsByYear W21671027902012 @default.
• W2167102790 countsByYear W21671027902013 @default.
• W2167102790 countsByYear W21671027902014 @default.
• W2167102790 countsByYear W21671027902015 @default.
• W2167102790 countsByYear W21671027902016 @default.
• W2167102790 countsByYear W21671027902017 @default.
• W2167102790 countsByYear W21671027902019 @default.
• W2167102790 countsByYear W21671027902021 @default.
• W2167102790 crossrefType "journal-article" @default.
• W2167102790 hasAuthorship W2167102790A5037198457 @default.
• W2167102790 hasAuthorship W2167102790A5037714226 @default.
• W2167102790 hasAuthorship W2167102790A5076459383 @default.
• W2167102790 hasBestOaLocation W21671027902 @default.
• W2167102790 hasConcept C126322002 @default.
• W2167102790 hasConcept C134018914 @default.
• W2167102790 hasConcept C150903083 @default.
• W2167102790 hasConcept C172680121 @default.
• W2167102790 hasConcept C207001950 @default.
• W2167102790 hasConcept C2776330855 @default.
• W2167102790 hasConcept C2777714996 @default.
• W2167102790 hasConcept C2778376644 @default.
• W2167102790 hasConcept C2778918659 @default.
• W2167102790 hasConcept C2779234561 @default.
• W2167102790 hasConcept C2780613262 @default.
• W2167102790 hasConcept C41625074 @default.
• W2167102790 hasConcept C46973012 @default.
• W2167102790 hasConcept C511355011 @default.
• W2167102790 hasConcept C54355233 @default.
• W2167102790 hasConcept C55493867 @default.
• W2167102790 hasConcept C58226133 @default.
• W2167102790 hasConcept C71924100 @default.
• W2167102790 hasConcept C86803240 @default.
• W2167102790 hasConceptScore W2167102790C126322002 @default.

• next