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- W2167117360 abstract "ABSTRACT Colistin penetration into the cerebrospinal fluid (CSF) was studied in five critically ill adult patients receiving colistin methanesulfonate for infections by multiresistant gram-negative bacilli. Colistin concentrations were determined in paired serum and CSF samples, with the latter taken by lumbar puncture, with the exception of one patient with an external ventriculostomy. CSF-to-serum ratios (0.051 to 0.057) for all study patients coincided at all sampling times. The low level (5%) of penetration suggests inadequate bactericidal colistin concentrations in the CSF." @default.
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- W2167117360 date "2009-11-01" @default.
- W2167117360 modified "2023-09-27" @default.
- W2167117360 title "Penetration of Colistin into Cerebrospinal Fluid" @default.
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- W2167117360 doi "https://doi.org/10.1128/aac.00345-09" @default.
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