Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167129013> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2167129013 endingPage "563.e2" @default.
- W2167129013 startingPage "558" @default.
- W2167129013 abstract "We sought to investigate the safety and feasibility of obtaining total respiratory support during 72 hours using a pump-driven (Levitronix CentriMag; Levitronix LLC, Waltham, Mass) venous-venous extracorporeal lung membrane (Novalung; Novalung GmbH, Hechingen, Germany) attached through a single double-lumen cannula (Novalung) into the femoral or jugular vein in pigs.Twelve pigs were initially mechanically ventilated for 2 hours (respiratory rate, 20-25 breaths/min; tidal volume, 10-12 mL/kg; fraction of inspired oxygen, 1.0; positive end-expiratory pressure, 5 cm H(2)O). Thereafter, the extracorporeal lung membrane was attached to the right femoral (n = 6, 26F) or jugular (n = 6, 22F) vein by using a single double-lumen cannula placed transcutaneously. Ventilatory settings were then reduced to near-apneic ventilation (respiratory rate, 4 breaths/min; tidal volume, 1-2 mL/kg; fraction of inspired oxygen, 0.21; positive end-expiratory pressure, 10 cm H(2)O), and pump flow was increased hourly until maximal efficacy. Blood gases and hemodynamics were measured hourly, and lung and plasma cytokine levels were measured every 4 hours.The device's mean blood flow was 2.16 +/- 0.43 L/min, permitting an oxygen transfer and carbon dioxide removal of 203.6 +/- 54.6 and 590.3 +/- 23.3 mL/min, respectively. Despite static ventilation, all pigs showed optimal respiratory support, with a PaO(2), PaCO(2), and mixed venous oxygen saturation of 226.2 +/- 56.4, 59.7 +/- 8.8, and 85.6 +/- 5.3 mm Hg, respectively. There were no significant inflammatory, cellular, or coagulatory responses; lung cytokine levels remained in the normal range. Route (femoral vs jugular) or size (22F vs 26F) of the cannula did not change hemodynamic or respiratory parameters significantly.This circuit provides total respiratory support over 72 hours without inducing significant hemodynamic, coagulatory, cellular, or inflammatory responses." @default.
- W2167129013 created "2016-06-24" @default.
- W2167129013 creator A5007596896 @default.
- W2167129013 creator A5018234817 @default.
- W2167129013 creator A5018931713 @default.
- W2167129013 creator A5065150677 @default.
- W2167129013 creator A5077017716 @default.
- W2167129013 creator A5078456366 @default.
- W2167129013 creator A5086260467 @default.
- W2167129013 date "2010-09-01" @default.
- W2167129013 modified "2023-10-15" @default.
- W2167129013 title "Single double-lumen venous–venous pump-driven extracorporeal lung membrane support" @default.
- W2167129013 cites W1980859550 @default.
- W2167129013 cites W1985647205 @default.
- W2167129013 cites W2019898786 @default.
- W2167129013 cites W2021554464 @default.
- W2167129013 cites W2023493493 @default.
- W2167129013 cites W2024820344 @default.
- W2167129013 cites W2031171285 @default.
- W2167129013 cites W2039544774 @default.
- W2167129013 cites W2045701287 @default.
- W2167129013 cites W2062493566 @default.
- W2167129013 cites W2080895900 @default.
- W2167129013 cites W2088031255 @default.
- W2167129013 cites W2092484310 @default.
- W2167129013 cites W2119907519 @default.
- W2167129013 cites W2150981118 @default.
- W2167129013 cites W2597070792 @default.
- W2167129013 doi "https://doi.org/10.1016/j.jtcvs.2009.12.057" @default.
- W2167129013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20723725" @default.
- W2167129013 hasPublicationYear "2010" @default.
- W2167129013 type Work @default.
- W2167129013 sameAs 2167129013 @default.
- W2167129013 citedByCount "12" @default.
- W2167129013 countsByYear W21671290132013 @default.
- W2167129013 countsByYear W21671290132014 @default.
- W2167129013 countsByYear W21671290132015 @default.
- W2167129013 countsByYear W21671290132016 @default.
- W2167129013 countsByYear W21671290132020 @default.
- W2167129013 crossrefType "journal-article" @default.
- W2167129013 hasAuthorship W2167129013A5007596896 @default.
- W2167129013 hasAuthorship W2167129013A5018234817 @default.
- W2167129013 hasAuthorship W2167129013A5018931713 @default.
- W2167129013 hasAuthorship W2167129013A5065150677 @default.
- W2167129013 hasAuthorship W2167129013A5077017716 @default.
- W2167129013 hasAuthorship W2167129013A5078456366 @default.
- W2167129013 hasAuthorship W2167129013A5086260467 @default.
- W2167129013 hasBestOaLocation W21671290131 @default.
- W2167129013 hasConcept C126322002 @default.
- W2167129013 hasConcept C141071460 @default.
- W2167129013 hasConcept C2776858399 @default.
- W2167129013 hasConcept C2777080012 @default.
- W2167129013 hasConcept C2777257755 @default.
- W2167129013 hasConcept C2778074680 @default.
- W2167129013 hasConcept C2778854125 @default.
- W2167129013 hasConcept C2778917391 @default.
- W2167129013 hasConcept C42219234 @default.
- W2167129013 hasConcept C534529494 @default.
- W2167129013 hasConcept C71924100 @default.
- W2167129013 hasConceptScore W2167129013C126322002 @default.
- W2167129013 hasConceptScore W2167129013C141071460 @default.
- W2167129013 hasConceptScore W2167129013C2776858399 @default.
- W2167129013 hasConceptScore W2167129013C2777080012 @default.
- W2167129013 hasConceptScore W2167129013C2777257755 @default.
- W2167129013 hasConceptScore W2167129013C2778074680 @default.
- W2167129013 hasConceptScore W2167129013C2778854125 @default.
- W2167129013 hasConceptScore W2167129013C2778917391 @default.
- W2167129013 hasConceptScore W2167129013C42219234 @default.
- W2167129013 hasConceptScore W2167129013C534529494 @default.
- W2167129013 hasConceptScore W2167129013C71924100 @default.
- W2167129013 hasIssue "3" @default.
- W2167129013 hasLocation W21671290131 @default.
- W2167129013 hasLocation W21671290132 @default.
- W2167129013 hasOpenAccess W2167129013 @default.
- W2167129013 hasPrimaryLocation W21671290131 @default.
- W2167129013 hasRelatedWork W1974725238 @default.
- W2167129013 hasRelatedWork W2017086358 @default.
- W2167129013 hasRelatedWork W2019176757 @default.
- W2167129013 hasRelatedWork W2030224583 @default.
- W2167129013 hasRelatedWork W2083117109 @default.
- W2167129013 hasRelatedWork W2089871326 @default.
- W2167129013 hasRelatedWork W2120076396 @default.
- W2167129013 hasRelatedWork W2792288654 @default.
- W2167129013 hasRelatedWork W2802620242 @default.
- W2167129013 hasRelatedWork W4253677767 @default.
- W2167129013 hasVolume "140" @default.
- W2167129013 isParatext "false" @default.
- W2167129013 isRetracted "false" @default.
- W2167129013 magId "2167129013" @default.
- W2167129013 workType "article" @default.