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• W2167142860 startingPage "2455" @default.
• W2167142860 abstract "The incidence of familial cases of premature ovarian failure varies from 4 to 31%. Recall bias may explain part of the variance. Thorough evaluation of alleged affected relatives showed a lower incidence than the original family history suggested. In the present study the incidence of familial cases was 12.7%. Pedigree studies on affected families showed a mode of inheritance suggestive of autosomal dominant sex-limited transmission or X-linked inheritance with incomplete penetrance. An adequate family history can distinguish between familial or sporadic premature ovarian failure. The risk of female relatives developing premature ovarian failure may be as high as 100% in familial premature ovarian failure, or as low as 1% in sporadic cases." @default.
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• W2167142860 date "1999-10-01" @default.
• W2167142860 modified "2023-10-08" @default.
• W2167142860 title "Familial idiopathic premature ovarian failure: an overrated and underestimated genetic disease?" @default.
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• W2167142860 doi "https://doi.org/10.1093/humrep/14.10.2455" @default.
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