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• W2167150493 abstract "Matrix metalloproteinases (MMPs) have been implicated in tumor cell invasion, metastasis, and angiogenesis. BAY 12-9566, a novel, non-peptidic biphenyl MMP inhibitor, has shown preclinical activity on a broad range of tumor models and is currently in clinical development. The purpose of this study was to investigate the antiangiogenic activity of BAY 12-9566. In vitro, BAY 12-9566 prevented matrix invasion by endothelial cells in a concentration-dependent manner (IC50 = 8.4x10(-7) M), without affecting cell proliferation. In vivo, oral daily administration of BAY 12-9566 (50-200 mg/kg) inhibited angiogenesis induced by basic fibroblast growth factor in the Matrigel plug assay, reducing the hemoglobin content of the pellets. Histological analysis showed a reduction in the amount of functional vessels within the Matrigel. We conclude that the MMP inhibitor BAY 12-9566 inhibits angiogenesis, a property that further supports its clinical development as an antimetastatic agent." @default.
• W2167150493 created "2016-06-24" @default.
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• W2167150493 date "1999-11-01" @default.
• W2167150493 modified "2023-09-23" @default.
• W2167150493 title "BAY 12-9566, a novel inhibitor of matrix metalloproteinases with antiangiogenic activity." @default.
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• W2167150493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10589777" @default.
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