Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167151901> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2167151901 endingPage "20" @default.
- W2167151901 startingPage "14" @default.
- W2167151901 abstract "Transforming growth factor-beta 1 (TGF-beta 1) inhibits the growth of intestinal cells, but the mechanisms involved are unknown. Using a rat intestinal crypt cell line (IEC-6), we determined the site of action in the cell cycle that TGF-beta 1 acts to suppress proliferation. We also examined the effect of TGF-beta 1 on the expression of proliferation-associated immediate early genes (zif268, jun-B, c-myc) during the early G1 phase and the cdc2 gene during the transition from the G1 phase to the S phase of the cell cycle. Cell cycle progression was determined by incorporation of 3H-thymidine, and gene expression was analyzed by Northern blot analysis. We found that TGF-beta 1 acts to inhibit proliferation of rat intestinal crypt cells by blocking cell cycle progression at the middle G1 phase. The genes activated during G1 can be divided into TGF-beta 1 insensitive (zif268, jun-B, and c-myc) and TGF-beta 1 sensitive (the cdc2 gene). TGF-beta 1 suppresses the induction of the cdc2 gene during the G1/S transition without inhibiting the activation of immediate early genes during the early G1 phase." @default.
- W2167151901 created "2016-06-24" @default.
- W2167151901 creator A5028293886 @default.
- W2167151901 creator A5051842779 @default.
- W2167151901 creator A5075774134 @default.
- W2167151901 creator A5079971195 @default.
- W2167151901 creator A5089912608 @default.
- W2167151901 date "1994-01-01" @default.
- W2167151901 modified "2023-09-30" @default.
- W2167151901 title "Transforming growth factor-β inhibits rat intestinal cell growth by regulating cell cycle specific gene expression" @default.
- W2167151901 cites W1631517817 @default.
- W2167151901 cites W1811606715 @default.
- W2167151901 cites W1897751061 @default.
- W2167151901 cites W1906149319 @default.
- W2167151901 cites W1974391793 @default.
- W2167151901 cites W1975392093 @default.
- W2167151901 cites W1977496565 @default.
- W2167151901 cites W2002008524 @default.
- W2167151901 cites W2039258037 @default.
- W2167151901 cites W2053432671 @default.
- W2167151901 cites W2060333964 @default.
- W2167151901 cites W2075164025 @default.
- W2167151901 cites W2085225127 @default.
- W2167151901 cites W2099985524 @default.
- W2167151901 cites W2105372948 @default.
- W2167151901 cites W2114024672 @default.
- W2167151901 cites W2116441979 @default.
- W2167151901 cites W2125380985 @default.
- W2167151901 cites W2128891019 @default.
- W2167151901 cites W2176189882 @default.
- W2167151901 cites W2283053703 @default.
- W2167151901 doi "https://doi.org/10.1016/0002-9610(94)90048-5" @default.
- W2167151901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8311125" @default.
- W2167151901 hasPublicationYear "1994" @default.
- W2167151901 type Work @default.
- W2167151901 sameAs 2167151901 @default.
- W2167151901 citedByCount "39" @default.
- W2167151901 countsByYear W21671519012014 @default.
- W2167151901 countsByYear W21671519012015 @default.
- W2167151901 countsByYear W21671519012017 @default.
- W2167151901 crossrefType "journal-article" @default.
- W2167151901 hasAuthorship W2167151901A5028293886 @default.
- W2167151901 hasAuthorship W2167151901A5051842779 @default.
- W2167151901 hasAuthorship W2167151901A5075774134 @default.
- W2167151901 hasAuthorship W2167151901A5079971195 @default.
- W2167151901 hasAuthorship W2167151901A5089912608 @default.
- W2167151901 hasConcept C104317684 @default.
- W2167151901 hasConcept C118131993 @default.
- W2167151901 hasConcept C120504264 @default.
- W2167151901 hasConcept C150194340 @default.
- W2167151901 hasConcept C153911025 @default.
- W2167151901 hasConcept C177707886 @default.
- W2167151901 hasConcept C2778229498 @default.
- W2167151901 hasConcept C29537977 @default.
- W2167151901 hasConcept C55493867 @default.
- W2167151901 hasConcept C62112901 @default.
- W2167151901 hasConcept C86803240 @default.
- W2167151901 hasConcept C95444343 @default.
- W2167151901 hasConceptScore W2167151901C104317684 @default.
- W2167151901 hasConceptScore W2167151901C118131993 @default.
- W2167151901 hasConceptScore W2167151901C120504264 @default.
- W2167151901 hasConceptScore W2167151901C150194340 @default.
- W2167151901 hasConceptScore W2167151901C153911025 @default.
- W2167151901 hasConceptScore W2167151901C177707886 @default.
- W2167151901 hasConceptScore W2167151901C2778229498 @default.
- W2167151901 hasConceptScore W2167151901C29537977 @default.
- W2167151901 hasConceptScore W2167151901C55493867 @default.
- W2167151901 hasConceptScore W2167151901C62112901 @default.
- W2167151901 hasConceptScore W2167151901C86803240 @default.
- W2167151901 hasConceptScore W2167151901C95444343 @default.
- W2167151901 hasIssue "1" @default.
- W2167151901 hasLocation W21671519011 @default.
- W2167151901 hasLocation W21671519012 @default.
- W2167151901 hasOpenAccess W2167151901 @default.
- W2167151901 hasPrimaryLocation W21671519011 @default.
- W2167151901 hasRelatedWork W1972744464 @default.
- W2167151901 hasRelatedWork W2009966535 @default.
- W2167151901 hasRelatedWork W2094505603 @default.
- W2167151901 hasRelatedWork W2162489064 @default.
- W2167151901 hasRelatedWork W2167151901 @default.
- W2167151901 hasRelatedWork W2366424044 @default.
- W2167151901 hasRelatedWork W2532041 @default.
- W2167151901 hasRelatedWork W3209090203 @default.
- W2167151901 hasRelatedWork W4244660752 @default.
- W2167151901 hasRelatedWork W4280493527 @default.
- W2167151901 hasVolume "167" @default.
- W2167151901 isParatext "false" @default.
- W2167151901 isRetracted "false" @default.
- W2167151901 magId "2167151901" @default.
- W2167151901 workType "article" @default.