Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167156988> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2167156988 endingPage "860" @default.
- W2167156988 startingPage "855" @default.
- W2167156988 abstract "Nocturnal melatonin pineal output is triggered by sympathetic outflow. Antidepressants that block norepinephrine neuronal uptake should increase pineal function. This can be monitored by measuring 6-sulfatoximelatonin (aMT6s), the main melatonin metabolite, in the urine. In this study, we compared the excretion of aMT6s before (baseline), one, and 21 days after administration of clomipramine to healthy subjects (n = 32). At the end of treatment, subjects were divided into responders (n = 12) and non-responders (n = 20) according to the improvement in their emotional state in three out of four domains (interpersonal tolerance, efficiency, well-being and feeling different from the usual self). There was no difference in aMT6s before clomipramine between responders and non-responders in any of the time intervals analysed (06:00—12:00, 12:00—18:00, 18:00—24:00 and 24:00—06:00 hours). At day one, but not at day 21, the fraction of aMT6s excreted during the time interval 24:00—06:00, relative to the total amount excreted by each subject per day, was significantly higher (P = 0.0287) than baseline (0.57 ± 0.04) in responders. No significant difference was observed in non-responders. The increase in pineal function induced by clomipramine was restricted to day one, indicating that long-lasting adaptation restores pineal function. In addition, the day one increase in aMT6s was significantly increased only in the responders group, raising the possibility that the blocking of neuronal uptake is predictive of emotional improvement." @default.
- W2167156988 created "2016-06-24" @default.
- W2167156988 creator A5020916691 @default.
- W2167156988 creator A5037794065 @default.
- W2167156988 creator A5041642617 @default.
- W2167156988 creator A5044201025 @default.
- W2167156988 creator A5080448373 @default.
- W2167156988 date "2009-03-05" @default.
- W2167156988 modified "2023-09-27" @default.
- W2167156988 title "Acute increase in urinary 6-sulfatoximelatonin after clomipramine, as a predictive measure for emotional improvement" @default.
- W2167156988 cites W1635886319 @default.
- W2167156988 cites W1966460145 @default.
- W2167156988 cites W1966667933 @default.
- W2167156988 cites W1968607731 @default.
- W2167156988 cites W1973289465 @default.
- W2167156988 cites W1999523141 @default.
- W2167156988 cites W2005333361 @default.
- W2167156988 cites W2016023013 @default.
- W2167156988 cites W2019990761 @default.
- W2167156988 cites W2025232067 @default.
- W2167156988 cites W2045903681 @default.
- W2167156988 cites W2046358782 @default.
- W2167156988 cites W2055628680 @default.
- W2167156988 cites W2064329212 @default.
- W2167156988 cites W2070026129 @default.
- W2167156988 cites W2074749226 @default.
- W2167156988 cites W2077198908 @default.
- W2167156988 cites W2078056668 @default.
- W2167156988 cites W2078621292 @default.
- W2167156988 cites W2089180488 @default.
- W2167156988 cites W2089326624 @default.
- W2167156988 cites W2089472180 @default.
- W2167156988 cites W2111561559 @default.
- W2167156988 cites W2114983488 @default.
- W2167156988 cites W2126996024 @default.
- W2167156988 cites W2155964805 @default.
- W2167156988 cites W2170485939 @default.
- W2167156988 cites W2172224545 @default.
- W2167156988 doi "https://doi.org/10.1177/0269881109102542" @default.
- W2167156988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19264813" @default.
- W2167156988 hasPublicationYear "2009" @default.
- W2167156988 type Work @default.
- W2167156988 sameAs 2167156988 @default.
- W2167156988 citedByCount "10" @default.
- W2167156988 countsByYear W21671569882012 @default.
- W2167156988 countsByYear W21671569882019 @default.
- W2167156988 countsByYear W21671569882021 @default.
- W2167156988 countsByYear W21671569882023 @default.
- W2167156988 crossrefType "journal-article" @default.
- W2167156988 hasAuthorship W2167156988A5020916691 @default.
- W2167156988 hasAuthorship W2167156988A5037794065 @default.
- W2167156988 hasAuthorship W2167156988A5041642617 @default.
- W2167156988 hasAuthorship W2167156988A5044201025 @default.
- W2167156988 hasAuthorship W2167156988A5080448373 @default.
- W2167156988 hasConcept C126322002 @default.
- W2167156988 hasConcept C134018914 @default.
- W2167156988 hasConcept C15744967 @default.
- W2167156988 hasConcept C2778182776 @default.
- W2167156988 hasConcept C2779305415 @default.
- W2167156988 hasConcept C2780026642 @default.
- W2167156988 hasConcept C2780059843 @default.
- W2167156988 hasConcept C71924100 @default.
- W2167156988 hasConcept C77411442 @default.
- W2167156988 hasConceptScore W2167156988C126322002 @default.
- W2167156988 hasConceptScore W2167156988C134018914 @default.
- W2167156988 hasConceptScore W2167156988C15744967 @default.
- W2167156988 hasConceptScore W2167156988C2778182776 @default.
- W2167156988 hasConceptScore W2167156988C2779305415 @default.
- W2167156988 hasConceptScore W2167156988C2780026642 @default.
- W2167156988 hasConceptScore W2167156988C2780059843 @default.
- W2167156988 hasConceptScore W2167156988C71924100 @default.
- W2167156988 hasConceptScore W2167156988C77411442 @default.
- W2167156988 hasIssue "6" @default.
- W2167156988 hasLocation W21671569881 @default.
- W2167156988 hasLocation W21671569882 @default.
- W2167156988 hasOpenAccess W2167156988 @default.
- W2167156988 hasPrimaryLocation W21671569881 @default.
- W2167156988 hasRelatedWork W1972126140 @default.
- W2167156988 hasRelatedWork W2009692691 @default.
- W2167156988 hasRelatedWork W2017830665 @default.
- W2167156988 hasRelatedWork W2050416457 @default.
- W2167156988 hasRelatedWork W2058382634 @default.
- W2167156988 hasRelatedWork W2069765647 @default.
- W2167156988 hasRelatedWork W2075463443 @default.
- W2167156988 hasRelatedWork W2092341993 @default.
- W2167156988 hasRelatedWork W2133675714 @default.
- W2167156988 hasRelatedWork W2797587270 @default.
- W2167156988 hasVolume "24" @default.
- W2167156988 isParatext "false" @default.
- W2167156988 isRetracted "false" @default.
- W2167156988 magId "2167156988" @default.
- W2167156988 workType "article" @default.