Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167161886> ?p ?o ?g. }
- W2167161886 endingPage "45" @default.
- W2167161886 startingPage "139" @default.
- W2167161886 abstract "Little is known about the etiology of pancreatic cancer, which is an important cause of cancer mortality in developed countries. We hypothesize that exposure to cadmium is a cause of pancreatic cancer. Cadmium is a nonessential metal that is known to accumulate in the human pancreas. The major risk factors for pancreatic cancer (increasing age, cigarette smoking, residence in Louisiana, and occupations involving exposure to metalworking and pesticides) are all associated with increased exposure to cadmium. Our meta-analysis of cohorts with high exposure to cadmium is also consistent with an increased risk of pancreatic cancer (standardized mortality ratio = 166; 95% confidence interval, 98-280; P = 0.059). Cadmium can cause the transdifferentiation of pancreatic cells, increases in the synthesis of pancreatic DNA, and increases in oncogene activation. Thus, cadmium is a plausible pancreatic carcinogen. The cadmium hypothesis provides a coherent explanation for much of the descriptive epidemiology of pancreatic cancer and suggests new avenues for analytical research." @default.
- W2167161886 created "2016-06-24" @default.
- W2167161886 creator A5008718884 @default.
- W2167161886 creator A5062422300 @default.
- W2167161886 date "2000-02-01" @default.
- W2167161886 modified "2023-09-23" @default.
- W2167161886 title "Is cadmium a cause of human pancreatic cancer?" @default.
- W2167161886 cites W100425916 @default.
- W2167161886 cites W1534227613 @default.
- W2167161886 cites W1543203145 @default.
- W2167161886 cites W1554793449 @default.
- W2167161886 cites W1579674409 @default.
- W2167161886 cites W1585124497 @default.
- W2167161886 cites W1587848431 @default.
- W2167161886 cites W1604979160 @default.
- W2167161886 cites W1624144317 @default.
- W2167161886 cites W1648274033 @default.
- W2167161886 cites W1655441320 @default.
- W2167161886 cites W17205842 @default.
- W2167161886 cites W1761048159 @default.
- W2167161886 cites W1774678331 @default.
- W2167161886 cites W1846086910 @default.
- W2167161886 cites W1847637099 @default.
- W2167161886 cites W1957866596 @default.
- W2167161886 cites W1964573683 @default.
- W2167161886 cites W1968402698 @default.
- W2167161886 cites W1969553862 @default.
- W2167161886 cites W1976204353 @default.
- W2167161886 cites W1976844606 @default.
- W2167161886 cites W197752284 @default.
- W2167161886 cites W1980409593 @default.
- W2167161886 cites W1980635520 @default.
- W2167161886 cites W1981055133 @default.
- W2167161886 cites W1982971413 @default.
- W2167161886 cites W1983170064 @default.
- W2167161886 cites W1984223770 @default.
- W2167161886 cites W1987928027 @default.
- W2167161886 cites W1989016417 @default.
- W2167161886 cites W1991098070 @default.
- W2167161886 cites W1991890132 @default.
- W2167161886 cites W1994929722 @default.
- W2167161886 cites W1997480974 @default.
- W2167161886 cites W1998081811 @default.
- W2167161886 cites W1998136247 @default.
- W2167161886 cites W1999053283 @default.
- W2167161886 cites W1999761122 @default.
- W2167161886 cites W2001246347 @default.
- W2167161886 cites W2003213669 @default.
- W2167161886 cites W2009302105 @default.
- W2167161886 cites W2009413871 @default.
- W2167161886 cites W2012090817 @default.
- W2167161886 cites W2014352182 @default.
- W2167161886 cites W2014912490 @default.
- W2167161886 cites W2025917991 @default.
- W2167161886 cites W2027102108 @default.
- W2167161886 cites W2027678736 @default.
- W2167161886 cites W2033968836 @default.
- W2167161886 cites W2035656970 @default.
- W2167161886 cites W2037067089 @default.
- W2167161886 cites W2038421530 @default.
- W2167161886 cites W2038789645 @default.
- W2167161886 cites W2040543347 @default.
- W2167161886 cites W2041258906 @default.
- W2167161886 cites W2045176314 @default.
- W2167161886 cites W2045877012 @default.
- W2167161886 cites W2046542063 @default.
- W2167161886 cites W2048970891 @default.
- W2167161886 cites W2052300655 @default.
- W2167161886 cites W2054326303 @default.
- W2167161886 cites W2054841241 @default.
- W2167161886 cites W2063649625 @default.
- W2167161886 cites W2064086130 @default.
- W2167161886 cites W2066229521 @default.
- W2167161886 cites W2067084274 @default.
- W2167161886 cites W2067228463 @default.
- W2167161886 cites W2069724117 @default.
- W2167161886 cites W2072636047 @default.
- W2167161886 cites W2076244798 @default.
- W2167161886 cites W2076372895 @default.
- W2167161886 cites W2081499475 @default.
- W2167161886 cites W2085456922 @default.
- W2167161886 cites W2087583082 @default.
- W2167161886 cites W2090106702 @default.
- W2167161886 cites W2092431255 @default.
- W2167161886 cites W2092984428 @default.
- W2167161886 cites W2094488271 @default.
- W2167161886 cites W2095333843 @default.
- W2167161886 cites W2095515780 @default.
- W2167161886 cites W2095773530 @default.
- W2167161886 cites W2098227343 @default.
- W2167161886 cites W2105758670 @default.
- W2167161886 cites W2106245192 @default.
- W2167161886 cites W2110327869 @default.
- W2167161886 cites W2125649475 @default.
- W2167161886 cites W2127099649 @default.
- W2167161886 cites W2127732086 @default.
- W2167161886 cites W2132515772 @default.
- W2167161886 cites W2139032462 @default.