FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167177203> ?p ?o ?g. }

• W2167177203 endingPage "2892" @default.
• W2167177203 startingPage "2885" @default.
• W2167177203 abstract "ABSTRACT Hydroxyurea has been shown to potentiate the anti-human immunodeficiency virus activities of 2′,3′-dideoxynucleoside analogs such as didanosine. We have now evaluated in vitro the effect of hydroxyurea on the antiherpesvirus activities of several nucleoside analogs (acyclovir [ACV], ganciclovir [GCV], penciclovir [PCV], lobucavir [LBV], ( R )-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine [H2G], and brivudin and nucleoside phosphonate analogs (cidofovir [CDV] and adefovir [ADV]). When evaluated in cytopathic effect (CPE) reduction assays, hydroxyurea by itself had little effect on CPE progression and potentiated in a subsynergistic (herpes simplex virus type 1 [HSV-1]) to synergistic (HSV-2) fashion the antiviral activities of ACV, GCV, PCV, LBV, H2G, ADV, and CDV. Hydroxyurea also caused marked increases in the activities of ACV, GCV, PCV, LBV, and H2G (compounds that depend for their activation on a virus-encoded thymidine kinase [TK]) against TK-deficient (TK − ) HSV-1. In fact, in combination with hydroxyurea the 50% effective concentrations of these compounds for inhibition of TK − HSV-1-induced CPE decreased from values of 20 to ≥100 μg/ml (in the absence of hydroxyurea) to values of 1 to 5 μg/ml (in the presence of hydroxyurea at 25 to 100 μg/ml). When evaluated in a single-cycle virus yield reduction assay, hydroxyurea at a concentration of 100 μg/ml inhibited progeny virus production by 60 to 90% but had little effect on virus yield at a concentration of 25 μg/ml. Under these assay conditions hydroxyurea still elicited a marked potentiating effect on the antiherpesvirus activities of GCV and CDV, but this effect was less pronounced than that in the CPE reduction assay. It is conceivable that the potentiating effect of hydroxyurea stems from a depletion of the intracellular deoxynucleoside triphosphate pools, thus favoring the triphosphates of the nucleoside analogues (or the diphosphates of the nucleoside phosphonate analogues) in their competition with the natural nucleotides at the viral DNA polymerase level. The possible clinical implications of these findings are discussed." @default.
• W2167177203 created "2016-06-24" @default.
• W2167177203 creator A5040662398 @default.
• W2167177203 creator A5089010495 @default.
• W2167177203 date "1999-12-01" @default.
• W2167177203 modified "2023-10-03" @default.
• W2167177203 title "Hydroxyurea Potentiates the Antiherpesvirus Activities of Purine and Pyrimidine Nucleoside and Nucleoside Phosphonate Analogs" @default.
• W2167177203 cites W1591151157 @default.
• W2167177203 cites W1972241043 @default.
• W2167177203 cites W1979894123 @default.
• W2167177203 cites W1987145430 @default.
• W2167177203 cites W1989408309 @default.
• W2167177203 cites W2001236884 @default.
• W2167177203 cites W2005229698 @default.
• W2167177203 cites W2018075369 @default.
• W2167177203 cites W2033939669 @default.
• W2167177203 cites W2043923548 @default.
• W2167177203 cites W2049686221 @default.
• W2167177203 cites W2058563502 @default.
• W2167177203 cites W2059286898 @default.
• W2167177203 cites W2061139890 @default.
• W2167177203 cites W2098768441 @default.
• W2167177203 cites W2102884468 @default.
• W2167177203 cites W2106498896 @default.
• W2167177203 cites W2130305699 @default.
• W2167177203 cites W2132130351 @default.
• W2167177203 cites W2140096403 @default.
• W2167177203 cites W2141277501 @default.
• W2167177203 cites W2142992472 @default.
• W2167177203 cites W2143498037 @default.
• W2167177203 cites W2154801452 @default.
• W2167177203 cites W2155275318 @default.
• W2167177203 cites W2159582645 @default.
• W2167177203 cites W2325369502 @default.
• W2167177203 cites W2345991699 @default.
• W2167177203 cites W2405719659 @default.
• W2167177203 cites W2413229695 @default.
• W2167177203 cites W76119661 @default.
• W2167177203 doi "https://doi.org/10.1128/aac.43.12.2885" @default.
• W2167177203 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/89582" @default.
• W2167177203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10582877" @default.
• W2167177203 hasPublicationYear "1999" @default.
• W2167177203 type Work @default.
• W2167177203 sameAs 2167177203 @default.
• W2167177203 citedByCount "14" @default.
• W2167177203 countsByYear W21671772032013 @default.
• W2167177203 countsByYear W21671772032017 @default.
• W2167177203 countsByYear W21671772032019 @default.
• W2167177203 crossrefType "journal-article" @default.
• W2167177203 hasAuthorship W2167177203A5040662398 @default.
• W2167177203 hasAuthorship W2167177203A5089010495 @default.
• W2167177203 hasBestOaLocation W21671772031 @default.
• W2167177203 hasConcept C153911025 @default.
• W2167177203 hasConcept C159047783 @default.
• W2167177203 hasConcept C185592680 @default.
• W2167177203 hasConcept C202751555 @default.
• W2167177203 hasConcept C2522874641 @default.
• W2167177203 hasConcept C2776147627 @default.
• W2167177203 hasConcept C2776159415 @default.
• W2167177203 hasConcept C2776543447 @default.
• W2167177203 hasConcept C2776723293 @default.
• W2167177203 hasConcept C2776724271 @default.
• W2167177203 hasConcept C2776824251 @default.
• W2167177203 hasConcept C2777108182 @default.
• W2167177203 hasConcept C2777333352 @default.
• W2167177203 hasConcept C2777447569 @default.
• W2167177203 hasConcept C2777965375 @default.
• W2167177203 hasConcept C2779820661 @default.
• W2167177203 hasConcept C2780216070 @default.
• W2167177203 hasConcept C2780727368 @default.
• W2167177203 hasConcept C2780796145 @default.
• W2167177203 hasConcept C2781196997 @default.
• W2167177203 hasConcept C55493867 @default.
• W2167177203 hasConcept C86803240 @default.
• W2167177203 hasConceptScore W2167177203C153911025 @default.
• W2167177203 hasConceptScore W2167177203C159047783 @default.
• W2167177203 hasConceptScore W2167177203C185592680 @default.
• W2167177203 hasConceptScore W2167177203C202751555 @default.
• W2167177203 hasConceptScore W2167177203C2522874641 @default.
• W2167177203 hasConceptScore W2167177203C2776147627 @default.
• W2167177203 hasConceptScore W2167177203C2776159415 @default.
• W2167177203 hasConceptScore W2167177203C2776543447 @default.
• W2167177203 hasConceptScore W2167177203C2776723293 @default.
• W2167177203 hasConceptScore W2167177203C2776724271 @default.
• W2167177203 hasConceptScore W2167177203C2776824251 @default.
• W2167177203 hasConceptScore W2167177203C2777108182 @default.
• W2167177203 hasConceptScore W2167177203C2777333352 @default.
• W2167177203 hasConceptScore W2167177203C2777447569 @default.
• W2167177203 hasConceptScore W2167177203C2777965375 @default.
• W2167177203 hasConceptScore W2167177203C2779820661 @default.
• W2167177203 hasConceptScore W2167177203C2780216070 @default.
• W2167177203 hasConceptScore W2167177203C2780727368 @default.
• W2167177203 hasConceptScore W2167177203C2780796145 @default.
• W2167177203 hasConceptScore W2167177203C2781196997 @default.
• W2167177203 hasConceptScore W2167177203C55493867 @default.
• W2167177203 hasConceptScore W2167177203C86803240 @default.
• W2167177203 hasIssue "12" @default.
• W2167177203 hasLocation W21671772031 @default.

• next