Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167190931> ?p ?o ?g. }
- W2167190931 endingPage "1155" @default.
- W2167190931 startingPage "1150" @default.
- W2167190931 abstract "Background There is increasing interest in discontinuing biological therapies for patients with rheumatoid arthritis (RA) achieving good clinical responses, provided patients maintain clinical benefit. Methods We assessed patients with RA from the Corrona registry who discontinued treatment with their first tumour necrosis factor inhibitor (TNFi) while in low-disease activity (LDA) or lower levels of disease activity. Patients were followed until they lost clinical benefit, defined as increased disease activity or change in RA medications. Duration of maintenance of clinical benefit was estimated using the Kaplan–Meier method. Cox proportional hazard models were assessed to identify factors related to maintenance of benefit. Results We identified 717 eligible patients with RA from 35 656 in the Corrona registry. At discontinuation, patients had a median RA duration of 8 years, mean clinical disease activity score of 4.3±0.11; 41.8% were using TNFi as monotherapy. 73.4% of patients maintained benefit for >12 months after discontinuing therapy and 42.2% did so through 24 months. Factors predictive of maintaining clinical benefit in multivariate analysis included lower disease activity, less pain and better functional status at the time of TNFi discontinuation. Among 301 patients initiating their first TNFi within the registry, faster responders (ie, those who achieved LDA in 4 months or less) did better than slower responders (HR 1.54 (95% CI 1.17 to 2.04)). RA disease duration did not affect maintenance of clinical benefit. Conclusions Discontinuation of a first course of TNFi may be associated with persistent clinical benefit. Half of patients maintained response through 20 months. Several patient characteristics may help predict persistent benefit." @default.
- W2167190931 created "2016-06-24" @default.
- W2167190931 creator A5000754711 @default.
- W2167190931 creator A5014045275 @default.
- W2167190931 creator A5014147030 @default.
- W2167190931 creator A5029648809 @default.
- W2167190931 creator A5030768494 @default.
- W2167190931 creator A5037010307 @default.
- W2167190931 creator A5040379318 @default.
- W2167190931 creator A5050398307 @default.
- W2167190931 creator A5082215179 @default.
- W2167190931 creator A5088662133 @default.
- W2167190931 creator A5089805011 @default.
- W2167190931 date "2014-12-03" @default.
- W2167190931 modified "2023-10-02" @default.
- W2167190931 title "Discontinuation of tumour necrosis factor inhibitors in patients with rheumatoid arthritis in low-disease activity: persistent benefits. Data from the Corrona registry" @default.
- W2167190931 cites W1761300068 @default.
- W2167190931 cites W1971061593 @default.
- W2167190931 cites W1987522198 @default.
- W2167190931 cites W1993827639 @default.
- W2167190931 cites W2000253156 @default.
- W2167190931 cites W2005429018 @default.
- W2167190931 cites W2044940757 @default.
- W2167190931 cites W2047412580 @default.
- W2167190931 cites W2062696198 @default.
- W2167190931 cites W2068338283 @default.
- W2167190931 cites W2075327204 @default.
- W2167190931 cites W2076610368 @default.
- W2167190931 cites W2105500082 @default.
- W2167190931 cites W2110520046 @default.
- W2167190931 cites W2114909821 @default.
- W2167190931 cites W2139126390 @default.
- W2167190931 cites W2151528423 @default.
- W2167190931 cites W2152553239 @default.
- W2167190931 cites W2155109530 @default.
- W2167190931 cites W2168751860 @default.
- W2167190931 cites W2313666147 @default.
- W2167190931 cites W4210768724 @default.
- W2167190931 cites W4234876404 @default.
- W2167190931 cites W4245335881 @default.
- W2167190931 cites W4247135939 @default.
- W2167190931 doi "https://doi.org/10.1136/annrheumdis-2014-206435" @default.
- W2167190931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25471471" @default.
- W2167190931 hasPublicationYear "2014" @default.
- W2167190931 type Work @default.
- W2167190931 sameAs 2167190931 @default.
- W2167190931 citedByCount "38" @default.
- W2167190931 countsByYear W21671909312015 @default.
- W2167190931 countsByYear W21671909312016 @default.
- W2167190931 countsByYear W21671909312017 @default.
- W2167190931 countsByYear W21671909312018 @default.
- W2167190931 countsByYear W21671909312019 @default.
- W2167190931 countsByYear W21671909312020 @default.
- W2167190931 countsByYear W21671909312021 @default.
- W2167190931 countsByYear W21671909312022 @default.
- W2167190931 crossrefType "journal-article" @default.
- W2167190931 hasAuthorship W2167190931A5000754711 @default.
- W2167190931 hasAuthorship W2167190931A5014045275 @default.
- W2167190931 hasAuthorship W2167190931A5014147030 @default.
- W2167190931 hasAuthorship W2167190931A5029648809 @default.
- W2167190931 hasAuthorship W2167190931A5030768494 @default.
- W2167190931 hasAuthorship W2167190931A5037010307 @default.
- W2167190931 hasAuthorship W2167190931A5040379318 @default.
- W2167190931 hasAuthorship W2167190931A5050398307 @default.
- W2167190931 hasAuthorship W2167190931A5082215179 @default.
- W2167190931 hasAuthorship W2167190931A5088662133 @default.
- W2167190931 hasAuthorship W2167190931A5089805011 @default.
- W2167190931 hasConcept C126322002 @default.
- W2167190931 hasConcept C207103383 @default.
- W2167190931 hasConcept C2777575956 @default.
- W2167190931 hasConcept C2778715236 @default.
- W2167190931 hasConcept C2779134260 @default.
- W2167190931 hasConcept C44249647 @default.
- W2167190931 hasConcept C50382708 @default.
- W2167190931 hasConcept C71924100 @default.
- W2167190931 hasConceptScore W2167190931C126322002 @default.
- W2167190931 hasConceptScore W2167190931C207103383 @default.
- W2167190931 hasConceptScore W2167190931C2777575956 @default.
- W2167190931 hasConceptScore W2167190931C2778715236 @default.
- W2167190931 hasConceptScore W2167190931C2779134260 @default.
- W2167190931 hasConceptScore W2167190931C44249647 @default.
- W2167190931 hasConceptScore W2167190931C50382708 @default.
- W2167190931 hasConceptScore W2167190931C71924100 @default.
- W2167190931 hasIssue "6" @default.
- W2167190931 hasLocation W21671909311 @default.
- W2167190931 hasLocation W21671909312 @default.
- W2167190931 hasOpenAccess W2167190931 @default.
- W2167190931 hasPrimaryLocation W21671909311 @default.
- W2167190931 hasRelatedWork W2082406232 @default.
- W2167190931 hasRelatedWork W2156283049 @default.
- W2167190931 hasRelatedWork W2170298832 @default.
- W2167190931 hasRelatedWork W2316954211 @default.
- W2167190931 hasRelatedWork W2326094713 @default.
- W2167190931 hasRelatedWork W2344781650 @default.
- W2167190931 hasRelatedWork W2427075784 @default.
- W2167190931 hasRelatedWork W2761967325 @default.
- W2167190931 hasRelatedWork W2899471050 @default.
- W2167190931 hasRelatedWork W3164131144 @default.