FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167201719> ?p ?o ?g. }

• W2167201719 abstract "Pulmonary arterial hypertension (PAH) is a rare and progressive vascular disorder characterized by increased pulmonary vascular resistance and right heart failure. The aim of this study was to analyze 5'UTR region in canonical transient receptor potential isoform 6 (TRPC6) and 3'UTR region in Angiotensin II type I receptor (AGTR1) genes in patients with idiopathic and associated PAH. Correlation among mutations and clinical and functional parameters was further analyzed.Analysis of TRPC6 and AGTR1 genes was performed by polymerase chain reaction (PCR) and direct sequencing. We used a non-parametric test to determine if significant differences were found between the groups studied and chi-square test to compare clinical and hemodynamic variables among genotypes.Fifty five patients and fifty two controls were included in this study. We found statistically significant differences for c.1-361A > T (p = 0.0077), c.1-254C > G (p < 0.0001) and c.1-218C > T (p = 0.0021) in TRPC6 gene and c.1166A > C (p < 0.001) in AGTR1 gene, between patients and controls. Idiopathic PAH patients (IPAH) and controls presented significant differences for all 3 TRPC6 polymorphisms (p = 0.020), (p = 0.002) and (p = 0.008) respectively, and also showed differences for AGTR1 gene (p < 0.001). In associated PAH (APAH) patients we found statistical differences for c.1-254C > G (p < 0.001) and c.1-218C > T (p = 0.001) in TRPC6 gene and c.1166A > C (p = 0.001) in AGTR1 gene. Several clinical and hemodynamic parameters showed significant differences between carriers and non-carriers of these single nucleotide polymorphisms (SNPs). Nineteen patients were carriers of all 3 SNPs in TRPC6 gene and presented a more severe phenotype with differences in mean pulmonary arterial pressure (p = 0.016), systolic pulmonary arterial pressure (p = 0.040), cardiac index (p < 0.001) and 6 minute walking test (p = 0.049). 16 of these patients harbored the SNP in AGTR1 gene. These patients showed differences in age at diagnosis (p = 0.049), mean pulmonary arterial pressure (p = 0.033), cardiac index (p = 0.002) and 6 minute walking test (p = 0.039).PAH is a rare disease with pulmonary vascular remodeling caused in part by a heterogeneous constellation of genetic arrangements. This study seems to suggest that c.1-361A > T, c.1-254C > G and c.1-218C > T polymorphisms in TRPC6 gene and c.1166A > C polymorphism in AGTR1 could have a role in the development of this disease." @default.
• W2167201719 created "2016-06-24" @default.
• W2167201719 creator A5019021410 @default.
• W2167201719 creator A5041470158 @default.
• W2167201719 creator A5075162505 @default.
• W2167201719 date "2015-01-21" @default.
• W2167201719 modified "2023-10-12" @default.
• W2167201719 title "Molecular and clinical analysis of TRPC6 and AGTR1 genes in patients with pulmonary arterial hypertension" @default.
• W2167201719 cites W1975716014 @default.
• W2167201719 cites W1977856772 @default.
• W2167201719 cites W1978147060 @default.
• W2167201719 cites W1981954827 @default.
• W2167201719 cites W1989584416 @default.
• W2167201719 cites W1989715435 @default.
• W2167201719 cites W2003758571 @default.
• W2167201719 cites W2008663940 @default.
• W2167201719 cites W2016280101 @default.
• W2167201719 cites W2020115179 @default.
• W2167201719 cites W2025973200 @default.
• W2167201719 cites W2033520419 @default.
• W2167201719 cites W2036145275 @default.
• W2167201719 cites W2036739405 @default.
• W2167201719 cites W2042075832 @default.
• W2167201719 cites W2044956310 @default.
• W2167201719 cites W2046393134 @default.
• W2167201719 cites W2049589518 @default.
• W2167201719 cites W2055792109 @default.
• W2167201719 cites W2059462860 @default.
• W2167201719 cites W2060253722 @default.
• W2167201719 cites W2062707374 @default.
• W2167201719 cites W2068721780 @default.
• W2167201719 cites W2069197415 @default.
• W2167201719 cites W2070650235 @default.
• W2167201719 cites W2105355154 @default.
• W2167201719 cites W2108789831 @default.
• W2167201719 cites W2117107897 @default.
• W2167201719 cites W2125263078 @default.
• W2167201719 cites W2127994875 @default.
• W2167201719 cites W2128475083 @default.
• W2167201719 cites W2141987653 @default.
• W2167201719 cites W2146011377 @default.
• W2167201719 cites W2150001571 @default.
• W2167201719 cites W2161603584 @default.
• W2167201719 cites W2169170284 @default.
• W2167201719 cites W2183644045 @default.
• W2167201719 cites W2187471514 @default.
• W2167201719 cites W2582602949 @default.
• W2167201719 cites W4212841357 @default.
• W2167201719 cites W4321428306 @default.
• W2167201719 doi "https://doi.org/10.1186/s13023-014-0216-3" @default.
• W2167201719 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4307182" @default.
• W2167201719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25603901" @default.
• W2167201719 hasPublicationYear "2015" @default.
• W2167201719 type Work @default.
• W2167201719 sameAs 2167201719 @default.
• W2167201719 citedByCount "33" @default.
• W2167201719 countsByYear W21672017192016 @default.
• W2167201719 countsByYear W21672017192017 @default.
• W2167201719 countsByYear W21672017192018 @default.
• W2167201719 countsByYear W21672017192019 @default.
• W2167201719 countsByYear W21672017192020 @default.
• W2167201719 countsByYear W21672017192021 @default.
• W2167201719 countsByYear W21672017192022 @default.
• W2167201719 countsByYear W21672017192023 @default.
• W2167201719 crossrefType "journal-article" @default.
• W2167201719 hasAuthorship W2167201719A5019021410 @default.
• W2167201719 hasAuthorship W2167201719A5041470158 @default.
• W2167201719 hasAuthorship W2167201719A5075162505 @default.
• W2167201719 hasBestOaLocation W21672017191 @default.
• W2167201719 hasConcept C126322002 @default.
• W2167201719 hasConcept C134018914 @default.
• W2167201719 hasConcept C164705383 @default.
• W2167201719 hasConcept C170493617 @default.
• W2167201719 hasConcept C178853913 @default.
• W2167201719 hasConcept C2780930700 @default.
• W2167201719 hasConcept C2908929049 @default.
• W2167201719 hasConcept C58245268 @default.
• W2167201719 hasConcept C71924100 @default.
• W2167201719 hasConcept C86803240 @default.
• W2167201719 hasConcept C90924648 @default.
• W2167201719 hasConceptScore W2167201719C126322002 @default.
• W2167201719 hasConceptScore W2167201719C134018914 @default.
• W2167201719 hasConceptScore W2167201719C164705383 @default.
• W2167201719 hasConceptScore W2167201719C170493617 @default.
• W2167201719 hasConceptScore W2167201719C178853913 @default.
• W2167201719 hasConceptScore W2167201719C2780930700 @default.
• W2167201719 hasConceptScore W2167201719C2908929049 @default.
• W2167201719 hasConceptScore W2167201719C58245268 @default.
• W2167201719 hasConceptScore W2167201719C71924100 @default.
• W2167201719 hasConceptScore W2167201719C86803240 @default.
• W2167201719 hasConceptScore W2167201719C90924648 @default.
• W2167201719 hasIssue "1" @default.
• W2167201719 hasLocation W21672017191 @default.
• W2167201719 hasLocation W21672017192 @default.
• W2167201719 hasLocation W21672017193 @default.
• W2167201719 hasLocation W21672017194 @default.
• W2167201719 hasOpenAccess W2167201719 @default.
• W2167201719 hasPrimaryLocation W21672017191 @default.
• W2167201719 hasRelatedWork W1989120855 @default.
• W2167201719 hasRelatedWork W1991657120 @default.

• next