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• W2167211837 abstract "Trigeminal motoneurons relay the final output signals generated within the oral-motor pattern generating circuit(s) to muscles for execution of various motor patterns. In recent years, these motoneurons were shown to possess voltage dependent nonlinear membrane properties that allow them to actively participate in sculpting their final output. A complete understanding of the factors controlling trigeminal motoneuronal (TMN) discharge during oral-motor activity requires, at a minimum, a detailed understanding of the palette of ion channels responsible for membrane excitability and a determination of whether these ion channels are targets for modulation. Toward that end, we studied in detail the properties of calcium channels in TMNs and their susceptibility to modulation by 5-HT in rat brain slices. We found that based on pharmacological and voltage-dependent properties, high-voltage-activated (HVA) N-type [ω-conotoxin GVIA (ω-CgTX)]-sensitive, and to a lesser extent P/Q-type [ω-agatoxin IVA (ω-Aga IVA)]-sensitive, calcium channels make up the majority of the whole cell calcium current. 5-HT (5.0 μM) decreased HVA current by 31.3 ± 2.2%, and the majority of this suppression resulted from reduction of current flow through N- and P/Q-type calcium channels. In contrast, 5-HT had no effect on low-voltage-activated (LVA) current amplitude in TMNs. HVA calcium current inhibition was mimicked by 5-CT, a 5-HT 1 receptor agonist, and by R(+)-8-hydroxydipropylaminotetralin hydrobromide (8-OH-DPAT), a specific 5-HT 1A agonist. The effects of 5-HT were blocked by the 5-HT 1A antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine hydrobromide (NAN-190) but not by ketanserin, a 5-HT 2/1C antagonist. Under current clamp, ω-CgTX and 5-HT were most effective in suppressing the mAHP and both increased the spike frequency and input/output gain in response to current injection. Calcium current modulation by 5-HT 1A receptors likely is an important mechanism to fine tune the input/output gain of TMNs in response to small incoming synaptic inputs and accounts for some of the previously reported effects of 5-HT on TMN excitability during tonic and burst activity during oral-motor behavior." @default.
• W2167211837 created "2016-06-24" @default.
• W2167211837 creator A5029117087 @default.
• W2167211837 creator A5032475942 @default.
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• W2167211837 date "2005-09-01" @default.
• W2167211837 modified "2023-10-15" @default.
• W2167211837 title "Voltage-Dependent Calcium Currents in Trigeminal Motoneurons of Early Postnatal Rats: Modulation by 5-HT Receptors" @default.
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• W2167211837 doi "https://doi.org/10.1152/jn.00178.2005" @default.
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