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• W2167234625 startingPage "813" @default.
• W2167234625 abstract "Emerging resistance to chloroquine (CQ) poses a major challenge for Plasmodium vivax malaria control, and nucleotide substitutions and copy number variation in the P. vivax multidrug resistance 1 (pvmdr-1) locus, which encodes a digestive vacuole membrane transporter, may modulate this phenotype. We describe patterns of genetic variation in pvmdr-1 alleles from Acre and Amazonas in northwestern Brazil, and compare then with those reported in other malaria-endemic regions. The pvmdr-1 mutation Y976F, which is associated with CQ resistance in Southeast Asia and Oceania, remains rare in northwestern Brazil (1.8%) and its prevalence mirrors that of CQ resistance worldwide. Gene amplification of pvmdr-1, which is associated with mefloquine resistance but increased susceptibility to CQ, remains relatively rare in northwestern Brazil (0.9%) and globally (< 4%), but became common (> 10%) in Tak Province, Thailand, possibly because of drug-mediated selection. The global database we have assembled provides a baseline for further studies of genetic variation in pvmdr-1 and drug resistance in P. vivax malaria." @default.
• W2167234625 created "2016-06-24" @default.
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• W2167234625 date "2012-11-07" @default.
• W2167234625 modified "2023-09-26" @default.
• W2167234625 title "Single-Nucleotide Polymorphism and Copy Number Variation of the Multidrug Resistance-1 Locus of Plasmodium vivax: Local and Global Patterns" @default.
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• W2167234625 doi "https://doi.org/10.4269/ajtmh.2012.12-0094" @default.
• W2167234625 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3516255" @default.
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