Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167244547> ?p ?o ?g. }
- W2167244547 endingPage "500" @default.
- W2167244547 startingPage "487" @default.
- W2167244547 abstract "The IL-1 family consists of 11 members that play an important role as key mediators in inflammation and immunity. Here, we report the identification of a new member of the IL-1 family (IL-1Fm2) that is present in species belonging to the most evolutionarily advanced group of teleost fish (Series Percomorpha), including Perciformes, Beloniformes, Gasterosteiformes, Cyprinodontiformes and Pleuronectiformes. However, IL-1Fm2 seems to be absent in Tetraodontiformes, which also belong to the Percomorpha. The expression pattern of gilthead seabream IL-1Fm2 revealed that although it was hardly induced by PAMPs, the combination of PAMPs and recombinant IL-1Fm2 synergistically induced its expression in macrophages and granulocytes. In addition, recombinant IL-1Fm2 was able to activate the respiratory burst of seabream phagocytes and to synergistically induce the expression of IL-1β, TNF-α, IL-8 and IL-10 when combined with PAMPs. Finally, although gilthead seabream IL-1Fm2 did not show a conserved caspase-1 processing site, macrophages processed IL-1Fm2 before being released. However, both pan-caspase and caspase-1 inhibitors failed to inhibit the processing and release of IL-1Fm2. These results demonstrate an important role of IL-1Fm2 in the regulation of fish immune responses, shed light on the evolution of the IL-1 family in vertebrates and point to the complexity of this cytokine family." @default.
- W2167244547 created "2016-06-24" @default.
- W2167244547 creator A5012166239 @default.
- W2167244547 creator A5013323935 @default.
- W2167244547 creator A5017096316 @default.
- W2167244547 creator A5036546654 @default.
- W2167244547 creator A5040972911 @default.
- W2167244547 creator A5051515194 @default.
- W2167244547 creator A5053234208 @default.
- W2167244547 creator A5069043702 @default.
- W2167244547 creator A5070280985 @default.
- W2167244547 creator A5073741910 @default.
- W2167244547 date "2013-09-12" @default.
- W2167244547 modified "2023-10-01" @default.
- W2167244547 title "Identification and functional characterization of a new IL-1 family member, IL-1Fm2, in most evolutionarily advanced fish" @default.
- W2167244547 cites W1484783481 @default.
- W2167244547 cites W1505229526 @default.
- W2167244547 cites W1556251771 @default.
- W2167244547 cites W1593615257 @default.
- W2167244547 cites W1963658775 @default.
- W2167244547 cites W1963763015 @default.
- W2167244547 cites W1964920567 @default.
- W2167244547 cites W1967342482 @default.
- W2167244547 cites W1969461218 @default.
- W2167244547 cites W1973043130 @default.
- W2167244547 cites W1979540275 @default.
- W2167244547 cites W1987893532 @default.
- W2167244547 cites W1988167511 @default.
- W2167244547 cites W1988197452 @default.
- W2167244547 cites W1989344162 @default.
- W2167244547 cites W2004806562 @default.
- W2167244547 cites W2008208329 @default.
- W2167244547 cites W2009504914 @default.
- W2167244547 cites W2026950841 @default.
- W2167244547 cites W2030522563 @default.
- W2167244547 cites W2037539108 @default.
- W2167244547 cites W2042465696 @default.
- W2167244547 cites W2042617388 @default.
- W2167244547 cites W2043544635 @default.
- W2167244547 cites W2047827229 @default.
- W2167244547 cites W2052874989 @default.
- W2167244547 cites W2056913899 @default.
- W2167244547 cites W2064668416 @default.
- W2167244547 cites W2095090055 @default.
- W2167244547 cites W2101524652 @default.
- W2167244547 cites W2102467166 @default.
- W2167244547 cites W2108244474 @default.
- W2167244547 cites W2109126129 @default.
- W2167244547 cites W2111581525 @default.
- W2167244547 cites W2130940574 @default.
- W2167244547 cites W2139341691 @default.
- W2167244547 cites W2144472999 @default.
- W2167244547 cites W2144564330 @default.
- W2167244547 cites W2144581273 @default.
- W2167244547 cites W2162760851 @default.
- W2167244547 cites W2166187656 @default.
- W2167244547 cites W2170936782 @default.
- W2167244547 cites W4210623056 @default.
- W2167244547 doi "https://doi.org/10.1177/1753425913501011" @default.
- W2167244547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24029144" @default.
- W2167244547 hasPublicationYear "2013" @default.
- W2167244547 type Work @default.
- W2167244547 sameAs 2167244547 @default.
- W2167244547 citedByCount "15" @default.
- W2167244547 countsByYear W21672445472014 @default.
- W2167244547 countsByYear W21672445472015 @default.
- W2167244547 countsByYear W21672445472016 @default.
- W2167244547 countsByYear W21672445472017 @default.
- W2167244547 countsByYear W21672445472019 @default.
- W2167244547 countsByYear W21672445472020 @default.
- W2167244547 countsByYear W21672445472021 @default.
- W2167244547 countsByYear W21672445472022 @default.
- W2167244547 countsByYear W21672445472023 @default.
- W2167244547 crossrefType "journal-article" @default.
- W2167244547 hasAuthorship W2167244547A5012166239 @default.
- W2167244547 hasAuthorship W2167244547A5013323935 @default.
- W2167244547 hasAuthorship W2167244547A5017096316 @default.
- W2167244547 hasAuthorship W2167244547A5036546654 @default.
- W2167244547 hasAuthorship W2167244547A5040972911 @default.
- W2167244547 hasAuthorship W2167244547A5051515194 @default.
- W2167244547 hasAuthorship W2167244547A5053234208 @default.
- W2167244547 hasAuthorship W2167244547A5069043702 @default.
- W2167244547 hasAuthorship W2167244547A5070280985 @default.
- W2167244547 hasAuthorship W2167244547A5073741910 @default.
- W2167244547 hasBestOaLocation W21672445471 @default.
- W2167244547 hasConcept C104317684 @default.
- W2167244547 hasConcept C203014093 @default.
- W2167244547 hasConcept C2778690821 @default.
- W2167244547 hasConcept C40767141 @default.
- W2167244547 hasConcept C54355233 @default.
- W2167244547 hasConcept C86803240 @default.
- W2167244547 hasConcept C8891405 @default.
- W2167244547 hasConcept C95444343 @default.
- W2167244547 hasConceptScore W2167244547C104317684 @default.
- W2167244547 hasConceptScore W2167244547C203014093 @default.
- W2167244547 hasConceptScore W2167244547C2778690821 @default.
- W2167244547 hasConceptScore W2167244547C40767141 @default.
- W2167244547 hasConceptScore W2167244547C54355233 @default.