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• W2167248487 abstract "A device using enzyme immunochromatography to indicate visually theophylline concentration in a small capillary blood sample was evaluated for precision and accuracy at four hospitals. Preliminary studies indicated sensitivity as low as 2·5 μg/ml, and accuracy and precision matched those in test samples ranging from 5 to 30 μg/ml. Absence of theophylline was also reliably detected. Paired samples of capillary and venous blood from 214 patients were used to compare this method with four standard laboratory assays. Correlations with the standard assays were 0·93-0·97, slopes 1·00-1·27, and y intercepts - 1·91-0·46. The within-run coefficients of variation on twenty replicate patient sample analyses at the four hospitals were 5·1-9·7% and between-run coefficients of variation on a 15·9 μg/ml control 5·7-9·4%. This disposable device for theophylline monitoring, which can be done within 15 min at the patient's side without instruments, is sufficiently accurate to replace laboratory analysis for routine therapeutic drug monitoring." @default.
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• W2167248487 date "1986-01-01" @default.
• W2167248487 modified "2023-09-27" @default.
• W2167248487 title "MULTICENTRE EVALUATION OF DISPOSABLE VISUAL MEASURING DEVICE TO ASSAY THEOPHYLLINE FROM CAPILLARY BLOOD SAMPLE" @default.
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• W2167248487 doi "https://doi.org/10.1016/s0140-6736(86)90655-0" @default.
• W2167248487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2868208" @default.
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