FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167257441> ?p ?o ?g. }

• W2167257441 endingPage "3061" @default.
• W2167257441 startingPage "3053" @default.
• W2167257441 abstract "BACKGROUND: Sr2+ is the most efficient agent for mouse oocyte activation and functions by inducing Ca2+ oscillations. However, its specific mechanism of action remains unknown. Here we investigated the specificity and possible mechanism of Sr2+-induced Ca2+ oscillations in mouse oocytes and early embryos. METHODS: Ca2+ oscillations in oocytes and embryos were measured by ratiometric fluorescence imaging using fura-2AM. The role of phospholipase C (PLC) and inositol trisphosphate (InsP3) receptors in Sr2+-induced Ca2+ oscillations was examined by selective inhibitors. RESULTS: Sr2+ can induce Ca2+ oscillations in both immature and mature oocytes, and in early embryos. A cell cycle stage-dependent phenomenon to Sr2+ stimulation was observed in 1-cell embryos. By using a low molecular weight heparin to antagonize the function of InsP3 receptors, we were able to show that InsP3 receptors are essential for Sr2+-induced Ca2+ oscillations. Treating metaphase II (MII) oocytes with the PLC inhibitor, U73122, abolished Sr2+-induced increases in Ca2+. This inhibitory effect of U73122 could be rescued by microinjection of InsP3, indicating that Sr2+-induced Ca2+ oscillations require the synergistic action of InsP3. CONCLUSIONS: Sr2+-induced calcium oscillations in mouse oocytes and early embryos are mediated through InsP3 receptors, and require PLC activation and the synergistic action of InsP3." @default.
• W2167257441 created "2016-06-24" @default.
• W2167257441 creator A5030611214 @default.
• W2167257441 creator A5038442604 @default.
• W2167257441 creator A5046521892 @default.
• W2167257441 creator A5057396658 @default.
• W2167257441 creator A5073575948 @default.
• W2167257441 creator A5091513274 @default.
• W2167257441 date "2005-07-29" @default.
• W2167257441 modified "2023-10-16" @default.
• W2167257441 title "Strontium promotes calcium oscillations in mouse meiotic oocytes and early embryos through InsP3 receptors, and requires activation of phospholipase and the synergistic action of InsP3" @default.
• W2167257441 cites W1434994921 @default.
• W2167257441 cites W1487014009 @default.
• W2167257441 cites W1497597518 @default.
• W2167257441 cites W1501322875 @default.
• W2167257441 cites W1519576356 @default.
• W2167257441 cites W1801735381 @default.
• W2167257441 cites W1985333504 @default.
• W2167257441 cites W1990602082 @default.
• W2167257441 cites W2002282185 @default.
• W2167257441 cites W2007278837 @default.
• W2167257441 cites W2009421992 @default.
• W2167257441 cites W2012183207 @default.
• W2167257441 cites W2033620401 @default.
• W2167257441 cites W2036664585 @default.
• W2167257441 cites W2042834905 @default.
• W2167257441 cites W2046522747 @default.
• W2167257441 cites W2053035086 @default.
• W2167257441 cites W2056240105 @default.
• W2167257441 cites W2063551001 @default.
• W2167257441 cites W2064541275 @default.
• W2167257441 cites W2067119870 @default.
• W2167257441 cites W2070640442 @default.
• W2167257441 cites W2079001764 @default.
• W2167257441 cites W2087448222 @default.
• W2167257441 cites W2090239388 @default.
• W2167257441 cites W2094059060 @default.
• W2167257441 cites W2097939257 @default.
• W2167257441 cites W2101731958 @default.
• W2167257441 cites W2112778436 @default.
• W2167257441 cites W2143040768 @default.
• W2167257441 cites W2150428929 @default.
• W2167257441 cites W2165292955 @default.
• W2167257441 cites W2171392147 @default.
• W2167257441 cites W2186667539 @default.
• W2167257441 cites W2213499550 @default.
• W2167257441 cites W2272821173 @default.
• W2167257441 cites W39364543 @default.
• W2167257441 doi "https://doi.org/10.1093/humrep/dei215" @default.
• W2167257441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16055456" @default.
• W2167257441 hasPublicationYear "2005" @default.
• W2167257441 type Work @default.
• W2167257441 sameAs 2167257441 @default.
• W2167257441 citedByCount "67" @default.
• W2167257441 countsByYear W21672574412012 @default.
• W2167257441 countsByYear W21672574412013 @default.
• W2167257441 countsByYear W21672574412014 @default.
• W2167257441 countsByYear W21672574412015 @default.
• W2167257441 countsByYear W21672574412016 @default.
• W2167257441 countsByYear W21672574412017 @default.
• W2167257441 countsByYear W21672574412018 @default.
• W2167257441 countsByYear W21672574412019 @default.
• W2167257441 countsByYear W21672574412020 @default.
• W2167257441 countsByYear W21672574412021 @default.
• W2167257441 countsByYear W21672574412022 @default.
• W2167257441 countsByYear W21672574412023 @default.
• W2167257441 crossrefType "journal-article" @default.
• W2167257441 hasAuthorship W2167257441A5030611214 @default.
• W2167257441 hasAuthorship W2167257441A5038442604 @default.
• W2167257441 hasAuthorship W2167257441A5046521892 @default.
• W2167257441 hasAuthorship W2167257441A5057396658 @default.
• W2167257441 hasAuthorship W2167257441A5073575948 @default.
• W2167257441 hasAuthorship W2167257441A5091513274 @default.
• W2167257441 hasBestOaLocation W21672574411 @default.
• W2167257441 hasConcept C12554922 @default.
• W2167257441 hasConcept C126322002 @default.
• W2167257441 hasConcept C134018914 @default.
• W2167257441 hasConcept C170493617 @default.
• W2167257441 hasConcept C179265757 @default.
• W2167257441 hasConcept C196843134 @default.
• W2167257441 hasConcept C202751555 @default.
• W2167257441 hasConcept C24998067 @default.
• W2167257441 hasConcept C2776120743 @default.
• W2167257441 hasConcept C2776690073 @default.
• W2167257441 hasConcept C2777427919 @default.
• W2167257441 hasConcept C2778597717 @default.
• W2167257441 hasConcept C2781387506 @default.
• W2167257441 hasConcept C519063684 @default.
• W2167257441 hasConcept C55493867 @default.
• W2167257441 hasConcept C62525196 @default.
• W2167257441 hasConcept C71924100 @default.
• W2167257441 hasConcept C86803240 @default.
• W2167257441 hasConcept C95444343 @default.
• W2167257441 hasConceptScore W2167257441C12554922 @default.
• W2167257441 hasConceptScore W2167257441C126322002 @default.
• W2167257441 hasConceptScore W2167257441C134018914 @default.
• W2167257441 hasConceptScore W2167257441C170493617 @default.
• W2167257441 hasConceptScore W2167257441C179265757 @default.

• next