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• W2167258145 abstract "Biofilms are structured communities of bacteria that are held together by an extracellular matrix consisting of protein and exopolysaccharide. Biofilms often have a limited lifespan, disassembling as nutrients become exhausted and waste products accumulate. D-amino acids were previously identified as a self-produced factor that mediates biofilm disassembly by causing the release of the protein component of the matrix in Bacillus subtilis. Here we report that B. subtilis produces an additional biofilm-disassembly factor, norspermidine. Dynamic light scattering and scanning electron microscopy experiments indicated that norspermidine interacts directly and specifically with exopolysaccharide. D-amino acids and norspermidine acted together to break down existing biofilms and mutants blocked in the production of both factors formed long-lived biofilms. Norspermidine, but not closely related polyamines, prevented biofilm formation by B. subtilis, Escherichia coli, and Staphylococcus aureus." @default.
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• W2167258145 date "2012-04-01" @default.
• W2167258145 modified "2023-09-29" @default.
• W2167258145 title "RETRACTED: A Self-Produced Trigger for Biofilm Disassembly that Targets Exopolysaccharide" @default.
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• W2167258145 doi "https://doi.org/10.1016/j.cell.2012.02.055" @default.
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