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- W2167266346 abstract "Expression of the human immunodeficiency virus type 1 (HIV-1) Env glycoprotein is stringently regulated in infected cells. The majority of the glycoprotein does not reach the cell surface but rather is retained in the endoplasmic reticulum or a cis-Golgi compartment and subsequently degraded. We here report that Env of various HIV-1 isolates is ubiquitinated at the extracellular domain of gp41 and that Env expression could be increased by lactacystin, a specific proteasome inhibitor, suggesting that the ubiquitin/proteasome system is involved in control of expression and degradation." @default.
- W2167266346 created "2016-06-24" @default.
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- W2167266346 date "2000-06-01" @default.
- W2167266346 modified "2023-09-26" @default.
- W2167266346 title "Ubiquitination of the Human Immunodeficiency Virus Type 1 Env Glycoprotein" @default.
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- W2167266346 doi "https://doi.org/10.1128/jvi.74.11.5373-5376.2000" @default.
- W2167266346 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/110895" @default.
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