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- W2167269580 abstract "<h3>Background:</h3> Regulatory T cells (T<sub>regs</sub>) have potential anti-inflammatory effects and are likely to be important in the pathogenesis of chronic inflammatory bowel disease (IBD). However, the induction and expansion of T<sub>regs</sub> at sites of mucosal inflammation are not yet fully understood and may involve antigen presentation by local dendritic cells (DCs) and/or intestinal epithelial cells (IECs). <h3>Methods:</h3> To determine the unique ways in which the gut induces or expands T<sub>regs</sub>, a transgenic mouse model that is based on the specific expression of a model autoantigen (influenza haemagglutinin (HA)) in the intestinal epithelium (VILLIN-HA) was used. Gut-associated DCs and IECs isolated from these mice were phenotypically and functionally characterised for the potential to interact with HA-specific T<sub>regs</sub> in vitro and in vivo. <h3>Results:</h3> Intestinal self-antigen expression leads to peripheral expansion of antigen-specific CD4<sup>+</sup>Foxp3<sup>+</sup> T<sub>regs</sub>. Although gut-associated DCs can induce antigen-specific CD4<sup>+</sup>Foxp3<sup>+</sup> T cell proliferation, in vivo depletion of DCs did not preclude proliferation of these cells. Interestingly, antigen presentation by primary IECs is sufficient to expand antigen-specific CD4<sup>+</sup>Foxp3<sup>+</sup> T<sub>regs</sub> efficiently. This is dependent on major histocompatibility complex class II, but, in contrast to DCs, is unlikely to require transforming growth factor β and retinoic acid. <h3>Conclusion:</h3> This study provides experimental evidence for a new concept in mucosal immunity: in contrast to current thinking, expansion of T<sub>regs</sub> can be achieved independently of local DCs through antigen-specific IEC–T cell interactions." @default.
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- W2167269580 date "2008-10-02" @default.
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- W2167269580 title "CD4+Foxp3+ regulatory T cell expansion induced by antigen-driven interaction with intestinal epithelial cells independent of local dendritic cells" @default.
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- W2167269580 doi "https://doi.org/10.1136/gut.2008.151720" @default.
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