FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2167282384> ?p ?o ?g. }

• W2167282384 abstract "Acute respiratory tract infections (ARTIs) are a major cause of childhood morbidity and mortality. Immunostimulants (IS) may reduce the incidence of ARTIs.To determine the efficacy and safety of IS in preventing ARTIs in children.We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 4, 2005); MEDLINE (January 1966 to January 2006); and EMBASE (January 1990 to January 2006); PASCAL (up to January 2006); SciSearch (up to January 2006); and IPA (up to January 2006) for reports of trials. Investigators in the field were also contacted. Ongoing studies were searched in the trial registration web site, metaRegister of Controlled Trials.All comparative trials which enrolled patients less than 18 years of age were included. The intervention of interest was the use of an IS medication administered by any method for preventing ARTIs. Clinical trials using random or quasi-random allocation and comparing IS medication or medications to placebo were included.The outcome on ARTIs was analyzed both as the mean number of ARTIs by group and as a percent change in the rate of ARTIs. Meta-analysis was undertaken using a random-effects model and results were presented as weighted mean differences (WMD) with 95% confidence intervals (CI). The trials search, quality assessment and data extraction were undertaken independently by two authors. A funnel plot suggested there may be publication bias in the trials identified.Thirty-four placebo controlled trials (3877 participants) provided data in a form suitable for inclusion in the meta-analysis. When compared with placebo, the use of IS was shown to reduce ARTIs measured as the total numbers of ARTIs (WMD -1.27; 95% CI -1.58 to -0.97) and the difference in ARTIs rates (WMD -39.68%; 95% CI -47.27% to -32.09%). The trial quality was generally poor and a high level of statistical heterogeneity was evident. The subgroup analysis of bacterial IS studies produced similar results, with lower heterogeneity. No difference in adverse events was evident between the placebo and IS groupsThis review showed that IS reduces the incidence of ARTIs in children, by 40% on average. However, due to significant heterogeneity and the poor quality of the trials this positive result should be interpreted with caution. The safety profile of IS appears to be good. Further high-quality trials are needed and we encourage national health authorities to conduct large, multicenter, double-blind, placebo-controlled trials on the role of IS in the prevention of ARTIs." @default.
• W2167282384 created "2016-06-24" @default.
• W2167282384 creator A5006553059 @default.
• W2167282384 creator A5013492956 @default.
• W2167282384 creator A5020808490 @default.
• W2167282384 creator A5057959686 @default.
• W2167282384 date "2006-10-18" @default.
• W2167282384 modified "2023-10-18" @default.
• W2167282384 title "Immunostimulants for preventing respiratory tract infection in children" @default.
• W2167282384 cites W1484565560 @default.
• W2167282384 cites W1525912444 @default.
• W2167282384 cites W1560114018 @default.
• W2167282384 cites W1565193648 @default.
• W2167282384 cites W1966497743 @default.
• W2167282384 cites W1967300438 @default.
• W2167282384 cites W1969734467 @default.
• W2167282384 cites W1969934047 @default.
• W2167282384 cites W1971972737 @default.
• W2167282384 cites W1972776583 @default.
• W2167282384 cites W1975643966 @default.
• W2167282384 cites W1979374514 @default.
• W2167282384 cites W1984151185 @default.
• W2167282384 cites W1985607069 @default.
• W2167282384 cites W1986231627 @default.
• W2167282384 cites W1989324226 @default.
• W2167282384 cites W1989814610 @default.
• W2167282384 cites W1991957164 @default.
• W2167282384 cites W1992019058 @default.
• W2167282384 cites W1994119684 @default.
• W2167282384 cites W1998747507 @default.
• W2167282384 cites W2001187841 @default.
• W2167282384 cites W2001819986 @default.
• W2167282384 cites W2002300697 @default.
• W2167282384 cites W2004233179 @default.
• W2167282384 cites W2005041676 @default.
• W2167282384 cites W2007491524 @default.
• W2167282384 cites W2008870732 @default.
• W2167282384 cites W2011138763 @default.
• W2167282384 cites W2013829912 @default.
• W2167282384 cites W2016736819 @default.
• W2167282384 cites W2018976239 @default.
• W2167282384 cites W2038758282 @default.
• W2167282384 cites W2047454295 @default.
• W2167282384 cites W2050047704 @default.
• W2167282384 cites W2050415939 @default.
• W2167282384 cites W2050436579 @default.
• W2167282384 cites W2053832675 @default.
• W2167282384 cites W2053935131 @default.
• W2167282384 cites W2055171241 @default.
• W2167282384 cites W2055395401 @default.
• W2167282384 cites W2056763100 @default.
• W2167282384 cites W2059168447 @default.
• W2167282384 cites W2061297849 @default.
• W2167282384 cites W2064020378 @default.
• W2167282384 cites W2068240651 @default.
• W2167282384 cites W2069462575 @default.
• W2167282384 cites W2072530712 @default.
• W2167282384 cites W2072997836 @default.
• W2167282384 cites W2075787303 @default.
• W2167282384 cites W2077913253 @default.
• W2167282384 cites W2079735320 @default.
• W2167282384 cites W2085116183 @default.
• W2167282384 cites W2085763011 @default.
• W2167282384 cites W2090746203 @default.
• W2167282384 cites W2093175349 @default.
• W2167282384 cites W2093963744 @default.
• W2167282384 cites W2094161521 @default.
• W2167282384 cites W2094279863 @default.
• W2167282384 cites W2094563797 @default.
• W2167282384 cites W2097014240 @default.
• W2167282384 cites W2099319343 @default.
• W2167282384 cites W2107533173 @default.
• W2167282384 cites W2111035947 @default.
• W2167282384 cites W2114626700 @default.
• W2167282384 cites W2115668399 @default.
• W2167282384 cites W2117483881 @default.
• W2167282384 cites W2125435699 @default.
• W2167282384 cites W2129276127 @default.
• W2167282384 cites W2137313784 @default.
• W2167282384 cites W2137407508 @default.
• W2167282384 cites W2138597393 @default.
• W2167282384 cites W2140477948 @default.
• W2167282384 cites W2144081943 @default.
• W2167282384 cites W2147230281 @default.
• W2167282384 cites W2151767234 @default.
• W2167282384 cites W2152240392 @default.
• W2167282384 cites W2154782136 @default.
• W2167282384 cites W2157823046 @default.
• W2167282384 cites W2160930945 @default.
• W2167282384 cites W2163480358 @default.
• W2167282384 cites W2167282384 @default.
• W2167282384 cites W2184741435 @default.
• W2167282384 cites W2260494648 @default.
• W2167282384 cites W2273207595 @default.
• W2167282384 cites W2317705821 @default.
• W2167282384 cites W2337235121 @default.
• W2167282384 cites W2399782355 @default.
• W2167282384 cites W3130204392 @default.
• W2167282384 cites W4206279929 @default.
• W2167282384 cites W4210967228 @default.

• next